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In the present work the genetically modified Trichoderma reesei strain QM9414 was used to produce full-length Ce17B (endoglucanase I, EGI) under the control of the constitutive Aspergillus nidulans gpdA promoter in the presence of glucose. However, the full-length Ce17B enzyme was found to be truncated to lower molecular weight components in the culture broth. Truncation of recombinant proteins pr
Microbial enzyme diversity is a key to understand many ecosystem processes. Whole metagenome sequencing (WMG) obtains information on functional genes, but it is costly and inefficient due to large amount of sequencing that is required. In this study, we have applied a captured metagenomics technique for functional genes in soil microorganisms, as an alternative to WMG. Large-scale targeting of fun
Modern treatment planning systems (TPSs) usually separate the dose modelling into a beam modelling phase, describing the beam exiting the accelerator, followed by a subsequent dose calculation in the patient. The aim of this work is to use the Monte Carlo code system EGSnrc to study the modelling of head scatter as well as the transmission through multi-leaf collimator (MLC) and diaphragms in the
We introduce a new dataset, Human3.6M, of 3.6 Million 3D Human poses, acquired by recording the performance of 11 subjects, under 4 different viewpoints, for training realistic human sensing systems and for evaluating the next generation of human pose estimation models. Besides increasing the size the current state of the art datasets by several orders of magnitude, we aim to complement such datas
Aims/hypothesis The relevance of the OGTT in predicting type 2 diabetes is unclear. We assessed the performance of 14 OGTT glucose traits in type 2 diabetes prediction. Methods We studied 2,603 and 2,386 Europeans from the Botnia study and Malmo Prevention Project (MPP) cohorts with baseline OGTT data. Over a follow-up period of 4.94 years and 23.5 years, 155 (5.95%) and 467 (19.57%) participants,
This work demonstrates the capacity of a ballistic imaging instrument to suppress diffuse photons and improve image contrast, making it possible to view fluid structure in a spray where a fog of droplets occludes the near field. Analysis of the system is performed by means of a numerical system model. The model simulates light propagation and scattering in the measurement volume using a Monte Carl
This thesis consists of theoretical studies of the evolutionary consequences of environmental change in ecological communities. Paper I and II are concerned with the origin of diversity, i.e. how a single lineage can split into two, under the influence of selection induced by competitive interactions (evolutionary branching). In paper I we find that environmental fluctuations may affect the likeli
The need to estimate indoor temperatures, heating or cooling load and energy requirements for buildings arises in many stages of a buildings life cycle, e.g. at the early layout stage, during the design of a building and for energy retrofitting planning. Other purposes are to meat the authorities requirements given in building codes. All these situations require good calculation methods. The main
Populärvetenskaplig beskrivning: Att veta hur olika saker i världen kom till hjälper en att släcka den törstiga sömn-förstörande nyfikenheten. Många har ställt sig frågan: hur skapades universum? Någorlunda hela svar har lagts fram (som till exempel teorin om Big Bang), men det finns mer att upptäcka. På en relativt mindre skala kan man fråga sig hur skapades Vintergatan? Ännu en fråga delvis svaradThe properties of the early Milky Way are quite mysterious and some are completely unknown even today. This study is the first one ever to analyze the mass distribution of Population III bulge stars. Using the fitting code STARFIT, we perform an analysis of 65 bulge metal-poor stars obtained by the EMBLA survey to estimate the IMF (initial mass function) of the very first stars that defined our ga
Den så kallade standardmodellen har länge betraktats som en av den moderna vetenskapens triumfer, tack vare dess oerhört exakta förutsägelser, som gång på gång har verifierats av experiment. Men från dess begynnelse har den alltid varit inkomplett: inte nog med att gravitationen, den kraft som vi människor är mest bekanta med, inte ens inkluderas i den så har olika, tidigare okända fenomen blivit In this project a two Higgs doublet model with a complex singlet and an extra family symmetry providing a mechanism for suppression of flavor changing neutral currents is explored. The goal is to investigate the phenomenological consistency of the model using a custom software framework. To this end, the scalar and Yukawa sectors of this extension of the Standard Model are explored in detail. The
Den svenska avloppsvattenreningsprocessen består av flera olika steg som utnyttjar mekanisk, kemisk och biologisk rening för att avlägsna så mycket av ohälsosamma ämnen och organismer som möjligt från vattenomloppet. Avloppsvattenreningsprocesserna i Sverige saknar specifika reningsmetoder för vissa typer av organiskt material, såsom läkemedelsrester. Dessa mikroföroreningar bryts enbart delvis neThe Swedish wastewater treatment processes consists of multiple steps including mechanical, chemical, and biological cleaning to remove as much of the unhealthy substances and organisms as possible from the water circulation. The wastewater treatment process in Sweden lacks specific removal methods for some types of organic material, such as pharmaceutical residues and other microcontaminants. The
I svensk lagstiftning är en samförståndslösning något som eftersträvas och anses vara barnets bästa. På flera ställen i vår lagbok, bland annat i Föräldrabalken och i Socialtjänstlagen, finns regleringar vad domare och socialtjänstemän är skyldiga att göra för att underlätta en samförståndslösning. Även i Norge ses samförståndslösningar som något positivt. Förutom de frivilliga samtalen på socialkIn Sweden, legislation has opened up to focus on finding an amicable solution that is in the best interest of the child. The possibilities of cooperation discussions are found in both the ‘Parental Code’ and the ‘Social Security Act’. Also in Norway, amicable solution is seen as something positive. In addition to the voluntary conversation at the Social Services, Norway also have mandatory mediati
This Master’s thesis in library and information science deals with the development of Länkskafferiet, a SBIG created in 1994 by NetLab of the University Library of Lund. Länkskafferiet maintains a selection of quality controlled Internet links for the use of Swedish school children. We have had access to archives and files from the start of Länkskafferiet in 1994 to 2005 and have also interviewed
Chemical abundances for 15 elements (C, N, O, Na, Mg, Al, Si, K, Ca, Ti, V, Cr, Mn, Fe, and Ni) are presented for 83 stellar members of the 4 Gyr old solar-metallicity open cluster M67. The sample contains stars spanning a wide range of evolutionary phases, from G dwarfs to red clump stars. The abundances were derived from near-IR (λ1.5-1.7 μm) high-resolution spectra (R ,F= ,F22,500) from the SD
Mantle cell lymphoma (MCL) is characterized by marked differences in outcome, emphasizing the need for strong prognostic biomarkers. Here, we explore expression patterns and prognostic relevance of circular RNAs (circRNAs), a group of endogenous non-coding RNA molecules, in MCL. We profiled the circRNA expression landscape using RNA-sequencing and explored the prognostic potential of 40 abundant c
Background: High-throughput sequencing often provides a foundation for experimental analyses in the life sciences. For many such methods, an intermediate layer of bioinformatics data analysis is the genomic signal track constructed by short read mapping to a particular genome assembly. There are many software tools to visualize genomic tracks in a web browser or with a stand-alone graphical user i
Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into th
