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BACKGROUND. Radiotherapy is a known risk factor for sarcoma development. Postirradiation sarcomas arise within the radiation field after a latency period of several years and usually are highly malignant. Very little is yet known about their genetic changes. METHODS. Twenty-seven postirradiation sarcomas were analyzed by comparative genomic hybridization, which allows genome-wide screening of DNA
To facilitate high-throughput biomarker discovery and high-density protein-chip array analyses of complex biological samples, a novel macro- and nanoporous silicon surface for protein microarrays was developed. The surface offers three-dimensional surface enlarging properties and spot confinement, enabling both high sensitivity bioassays and design of high density arrays. Reproducible manufacturin
Kursguide - Course Syllabus • • • • Details of approval The syllabus was approved by The Master's Programmes Board on 2016-04-26 to be valid from 2016-07-01, autumn semester 2016. General Information The course is a compulsory component of the Master (120 credits) of Medical Science programme in Public Health Language of instruction: English Learning outcomes Knowledge and understanding On complet
https://www.medicine.lu.se/sites/medicine.lu.se/files/mphp14.pdf - 2026-05-24
Background: Risk factors for rare gynecological cancers are largely unknown. Initial research has indicated that the metabolic syndrome (MetS) or individual components could play a role. Materials and methods: The Metabolic syndrome and Cancer project cohort includes 288 834 women. During an average follow-up of 11 years, 82 vulvar, 26 vaginal and 43 other rare gynecological cancers were identifie
Background: The prevalence of blindness and visual impairment from glaucoma is influenced by the criteria used to define these entities, which differ between countries and regions, as well as among published reports. The objective of the present study was to ascertain the extent to which different criteria of blindness and visual impairment influence estimates of the number of patients classified
The myeloid translocation gene 16 product MTG16 is found in multiple transcription factor-containing complexes as a regulator of gene expression implicated in development and tumorigenesis. A stable Tet-On system for doxycycline-dependent expression of MTG16 was established in B-lymphoblastoid Raji cells to unravel its molecular functions in transformed cells. A noticeable finding was that express
The familial risk of medullary thyroid carcinoma (MTC alone or as part of multiple endocrine neoplasms, MEN2A/MEN2B) is high, so we aimed to answer open questions about the lifetime cumulative risk of thyroid cancer (LCRTC at 0-79 years) among relatives of MTC patients by age and sex. For this nationwide study, a cohort of 3217 first-/second-degree relatives (FDRs/SDRs) of 389 MTC patients diagnos
An integrated product recovery system was developed to separate urokinase from the cell culture broth of human kidney cells HT1080. Supermacroporous monolithic cryogels provided ideal matrices with respect to surface and flow properties for use as cell culture scaffold as well as for affinity chromatographic capture step of the enzyme in the integrated system. The urokinase was produced continuous
PUFA from oil extracted from Nile perch viscera were enriched by selective enzymatic esterification of the free fatty acids (FFA) or by hydrolysis of ethyl esters of the fatty acids from the oil (FA-EE). Quantitative analysis was performed using RP-HPLC coupled to an evaporative light scattering detector (RP-HPLC-ELSD). The lipase from Thermomyces lanuginosus discriminated against docosahexaenoic
Transient experiments are one of many techniques available to study heterogeneous catalysis and the catalysts used. The results obtained by transient experiments contain valuable information that is helpful in explaining reaction mechanism and interaction at the catalytic surface. The work that was performed covers areas that reach from the selective (ammoxidation) and complete oxidation of propan
Several previous studies have demonstrated that severe hypoglycemia is accompanied by consumption of endogenous brain substrates (glycolytic and citric acid cycle metabolites and free amino acids) and some have shown a loss of structural components as well, notably phospholipids. In the present study, on paralysed and artificially ventilated rats, we measured cerebral oxygen and glucose consumptio
BACKGROUND. This study was performed in women who had attended the clinic for contraceptive advice to determine whether a history of casual sex with a foreign male, previously unknown to them (SFM) in their home country (Sweden), constituted an increased risk for acquiring sexually transmitted diseases (STD) as compared to women without such an experience (COMP). METHODS. Of 996 women enrolled, an
Our knowledge about acute promyelocytic leukemia (APL) patients is mainly based on data from clinical trials, whereas population-based information is scarce. We studied APL patients diagnosed between 1997 and 2006 in the population-based Swedish Adult Acute Leukemia Registry. Of a total of 3897 acute leukemia cases, 3205 (82%) had non-APL acute myeloid leukemia (AML) and 105 (2.7%) had APL. The in
För att undersöka nanopartiklars toxicitet finns behov av att producera väldefinierade nanopartiklar dispergerade i en kolloid suspension. Men även för andra områden så som nanomedicin finns ett behov av denna typ av lösningar. För att dispergera partiklarna i vätska används ofta ytaktiva ämnen. När dessa ämnen tillsätts adderas de på ytan av partikeln och förändrar partiklarnas yta. Då forskning To examine nanoparticle toxicity there is a need to produce defined nanoparticles dispersed in a colloidal suspension. Such a solution could also be interesting for other fields such as nano-medicine. In order to disperse the particles in the liquid there are often surfactant added to the process that alternates the surface of the particles. As the research shows that the surface of a nanoparticle
An estimated 6% of human greenhouse gas emissions are the result of enteric methane production by cows. Asparagopsis taxiformis, a semi-tropical alga, is one solution. Supplementation of this alga to cows at a small percentage of their daily intake has reduced methane emissions by over 98% in trials. This success has led to multiple commercialization attempts globally, although no Asparagopsis tax
Plant-insect interactions play a crucial role in the evolution of the coevolving web of life, shaping local interaction networks and moulding the diversity and the evolutionary history of two of the most diverse groups of organisms on earth. The interaction between Lithophragma bolanderi (Saxifragaceae), which presents a geographic mosaic of ploidy levels, and the pollinating floral parasite Greya
In recent years the railway has received a lot of negative publicity thanks to the large amount of delay hours that occurs during winter conditions and especially at snowfall. In our railway network, the points are the most targeted problem components were snow and ice cause the most problems. Due to its moving parts and low tolerances for disorder, a few millimeters of gap between the rails is en
In the summer of 2021 a massive rainfall caused floods in Gävleborg län. The flood contributed to high burden on SOS-alarm and the fire and rescue service when approximately 700 emergency calls were received in a short amount of time. The flood caused floodings in cellars, damage to infrastructure and problems moving through traffic. The high burden caused the inner commanding officer of the fire
This thesis analyses the debate around the patents on human genes from three most important angles: ethical, legal and economic. In the ethical context, patents on gene-related inventions are often seen as inappropriate because of the alleged special status of human DNA. The special status stems from their alleged responsibility for everything from diseases to social propensities and personal trai
The project has been developed from a proposal made by RegionService (technical real estate for Region Skåne) and based on the replacement of light fixtures from fluorescent lamps to white LEDs (Light Emitting Diodes) in some hallways in Helsingborgs Lasarett (The Hospital in Helsingborg). The results turned out to be positive and further replacement were made in nearby buildings as well. My part
