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The purpose of this article is to survey current knowledge concerning the consequences of a ligament injury on neuromuscular function and its relevance to rehabilitation, in relation to clinical practice. Although it deals with the ACL-injured knee, these views may also apply to other joints. The effects of a ligament injury on neuromuscular function are first considered - i.e., proprioception, po

Nuclear spin relaxation by intermolecular dipole–dipole interactions between macromolecular and solvent nuclear moments forms the basis of a widely used method for investigating macromolecular solvation. In particular, intermolecular cross-relaxation [or nuclear Overhauser effect (NOE)] between protein and water protons has been used to probe the mobility of water molecules interacting with the pr

Protein kinase C (PKC) isoforms have been reported to be targeted to the Golgi complex via their C1 domains. We have shown recently that the regulatory domain of PKCtheta induces apoptosis in neuroblastoma cells and that this effect is correlated to Golgi localization via the C1b domain. This study was designed to identify specific residues in the C1 domains that mediate Golgi localization. We dem

A Slepian model for the local behaviour near the level upcrossings of a chi²-process with dependent Gaussian components is presented. In case of independent components, this model is shown to take on a rather simple form, thereby simplifying earlier results by Aronowich and Adler. The Slepian model is applied to the envelope of a stationary Gaussian process and used to approximate the probabilit

In this article, Övdalian null subjects are introduced and analysed. A general background to Övdalian is provided, whereupon the possible null subjects (wįð ('we') and ið ('you')) are presented. Interestingly, these null subjects do not appear in the same syntactic positions; whereas null ið seems to be unrestricted, null wįð may only appear in positions immediately preceding the finite verb. It i

First-degree atrioventricular (AV) block is a delay within the AV conduction system and is defined as a prolongation of the PR interval beyond the upper limit of what is considered normal (generally 0.20 s). Up until recently, first-degree AV block was considered an entirely benign condition. In fact, some complain that it is a misnomer since there is only delay and no actual block in the AV condu

Heart failure is often complicated by arrhythmias that can adversely affect the quality of life and increase the risk for sudden cardiac death. Current risk stratification strategies for sudden cardiac death in the heart failure patient are not ideal, with much potential for further refinement. Overactivation of the sympathetic nervous system has been shown to be associated with worsening heart fa

Low-density lipoprotein (LDL) is the major atherogenic lipoprotein and the primary target of lipid-lowering therapy for treating ischemic cardiovascular disease. Apolipoprotein B (apoB), an important structural component of LDL, plays a key role in cholesterol transport and removal in vascular wall. On the other hand, under pathological process, apoB interacts with the arterial wall to initiate th

In this paper, I evaluate the usefulness of protein homology models in rigorous free-energy simulations to determine ligand affinities. Two templates were used to create models of the factor Xa protein and one template was used for dihydrofolate reductase from Plasmodium falciparum. Then, the relative free energies for several pairs of ligands were estimated using thermodynamic integration with th

As oil-prices and environmental concerns are increasing, it is of interest to better use the well-head gas. This light fraction co-produced with petroleum is generally flared and in this paper a method for upgrading and returning the co-product to the petroleum stream is suggested. The method is based on a conversion of the gas to synthesis gas and upgrading this synthesis gas into liquid hydrocar

In February 2007, an epidemic of severe dermatitis from Chinese recliner chairs and sofas started to unfold first in Finland and a few months later in the UK. Some patients reacted in patch tests (PTs) strongly to the material of their furniture, either leather or fabric. There have been hundreds of reports of chair or sofa dermatitis from Finland and the UK, with all cases linked to the same furn

To investigate visual outcome, bacteriology, and time to diagnosis in groups identified as being at risk for endophthalmitis following cataract surgery.

I det västerländska samhället kämpar vi för långa liv men mot åldrandet. Det är bara en av de motsägelser som ålder och åldrande ger upphov till. I Åldrandets betydelser undersöks olika förhållningssätt till och konsekvenser av åldrande. Boken belyser hur kronologisk ålder inte alltid är densamma som den upplevda och hur samhället möter olika åldrar. Exempel tas från såväl hälso- och sjukvården so

Internal erosion is one of the major reasons for embankment dam failures. Despite this, the knowledge of the temporal development of internal erosion in full scale structures is limited. Results from a research field monitoring program by daily resistivity measurements in Sweden clearly show long term changes in resistivity in the embankment dam. The results indicate that resistivity monitoring ca