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1. The mechanisms by which cooling inhibits insulin secretion were investigated by capacitance measurements of exocytosis in single mouse pancreatic B-cells maintained in short-term tissue culture. 2. A reduction of the bath temperature from 34 to 24 degrees C produced a gradual inhibition of exocytosis. Inhibition of exocytosis was use dependent rather than time dependent. The steady-state inhibi

OBJECTIVE. Severe (PiZZ) alpha(1)-antitrypsin (AAT) deficiency is a risk factor for liver disease, i.e. juvenile cirrhosis in infancy, and cirrhosis and hepatoma in adulthood. Little is known about the risk of liver disease in individuals with moderate (PiSZ) AAT deficiency. To investigate the natural course of AAT deficiency, a cohort of PiZZ and PiSZ individuals identified by the Swedish Nationa

Abstract is not available

Objective . The management of pancreatic pseudocysts varies, based mainly on local traditions, resources and expertise. No prospective, randomized study has been done comparing different approaches to treatment. The aim of the present study was to identify current treatment strategies in Sweden. Material and methods. A questionnaire comprising 12 questions was e-mailed to the surgical departments

While Aristotle has conventionally been perceived as a precursor for the taxonomy of modern biological systematics, such as that of Carolus Linnaeus, this essay investigates the relationship between Aristotelian metaphysics and natural history in order to demonstrate the problem of anomalies in any system of this kind. In particular, the problem involves the place that may be given to the unnatura

Exposure to isocyanates is known to have respiratory effects in workers and therefore it is essential to monitor the occupational exposure. An earlier study of a continuous foaming plant using toluene diisocyanate (TDI) showed that the exposure to isocyanates can be high. Since then several preventive actions were implemented at the plant. The aim of this study was to observe the effect of these a

Chronic pancreatitis is a relatively frequent condition usually caused by alcoholic abuse but also due to recurrent gallstone disease, metabolic endocrine disorders and haemochromatosis, among others. Specific types such as hereditary and autoimmune pancreatitis should be particularly kept in mind and emphasized, as they require specific treatment and attention. The possibility to identify gene mu

In Hälsingland, Sweden, there are approximately a thousand Hälsingegårdar; big farm houses with lavishly decorated rooms typical for the region. These farmhouses have been the subjects of much research, mainly with a focus on their economical background, or restoration aspects. There has been no archaeological research done on these farmhouses, and thus an archaeological perspective is lacking in

Sammanfattning I uppsatsen har syftet med 3:12-reglerna, särskilt utomståenderegeln i 57 kap. 5§ IL, framställts och analyserats. Därjämte studien har ägnats åt att undersöka hur praxis stämmer överens med utomståenderegelns ändamål. Metoden som har tillämpats är den rättsdogmatiska metoden, vilket innebär att undersökningen genomförs med hjälp av rättskällorna så som förarbeten, författning, praAbstract The purpose of the essay is to describe and analyze the motive that was behind the 3:12 rules, especially the outsider rule, and to examine how practice is consistent with its purpose. The main starting point for the regulations in question was that the taxpayer who owns shares and works in the company should, as far as possible, receive similar taxation for capital gains or work compens

Sverige har sedan år 1990 haft en reglering mot insiderhandel. Innan dess var det den så kallade självregleringen, skapad av marknadens egna aktörer, som reglerade insiderbrottet. Lagen har dock utvecklats och omarbetats många gånger genom EU direktiv och förordningar fram till den idag gällande marknadsmissbrukslagen. Trots detta kritiseras regleringen för att vara ineffektiv och svår att tillämp

Kazuo Ishiguro's novel The Remains of the Day has garnered much discussion by literary theorists. Studies have primarily concerned themselves with the main character Mr Stevens and how he interacts with the complex situations around him. A frequent question is of his reliability, as there are indications that he does not give correct interpretations of events. This essay uses poststructuralist

Conventional wisdom suggests, in the face of deepening European integration, that without some form of tax harmonisation "a race to the bottom" would ensue undermining the foundations of Europe's welfare states. Such wisdom can be questioned on two grounds. Firstly, Member States are not on the same "playing field" as there is great disparity between the various Member Stat

Religionsfriheten som stadfästs i artikel 9 EKMR kan under vissa förutsättningar bli föremål för inskränkningar. En av dessa förutsättningar är att inskränkningen måste vara nödvändig i ett demokratiskt samhälle. Vid avgörandet av huruvida en sådan nödvändighet föreligger kan konventionsstaten tillerkännas en viss skönsmarginal av Europadomstolen. Innebörden av det blir att staten ges ett visst eg