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Here we report the first survey of galectin binding to glycoproteins of human serum. Serum was subjected to affinity chromatography using immobilized galectins, and the bound glycoproteins were analyzed by electrophoresis, Western blotting, and mass spectrometry. Galectins-3, -8 and -9 bound a much broader range of ligands in serum than previously known, galectin-1 bound less, and galectins-2, -4
Artikeln presenterar två kvalitativa studier som fokuserat barns användning av och relation till platser utomhus utifrån barns perspektiv. Studierna genomfördes vid olika tidpunkter, i mitten av 1990-talet och under åren 2008–2009, med barn i ungefär samma åldrar (9–11 år), med liknande metoder och i snarlika typer av bostadsmiljöer, men i två olika svenska städer. Teoretiska utgångspunkter hämtas
The production of photons at very small angles with respect to the proton beam direction is studied in deep-inelastic positron-proton scattering at HERA. The data are taken with the H1 detector in the years 2006 and 2007 and correspond to an integrated luminosity of 126 pb(-1). The analysis covers the range of negative four momentum transfer squared at the positron vertex 6 < Q(2) < 100 GeV2 and i
L-type voltage-gated Ca2+ channels are expressed in the plasma membrane of muscles, neurons and endocrine cells where they serve as conductors of signals regulating cellular responses to changes in environment. Malfunctions of channels, as well as deregulations of their activity underlie numerous disorders and diseases commonly called channelopathies. In β-cells Ca2+ channels are central players f
Objectives To determine the sensitivity and specificity of subjective evaluation of gray-scale and Doppler ultrasound findings (here called pattern recognition) when used by experienced ultrasound examiners with regard to making a specific diagnosis of adnexal masses. Methods Within the framework of a European multi-center study, the International Ovarian Tumor Analysis study, comprising nine ultr
The influence of charge and aromatic stacking interactions on the self-assembly of a series of four model amyloid peptides has been examined. The four model peptides are based on the KLVFF motif from the amyloid beta peptide, A beta(16-20) extended at the N terminus with two P-alanine residues. We have studied NH2-beta A beta AKLVFF-COOH (FF), NH2-beta A beta AKLVF-COOH (F), CH3CONH-beta A beta AK
Neutrophil-mediated lung injury is an insidious feature in sepsis although the mechanisms regulating pulmonary recruitment of neutrophils remain elusive. Here, we investigated the role of P-selectin glycoprotein-ligand-1 (PSGL-1) in sepsis-induced neutrophil recruitment and tissue injury in the lung. Bronchoalveolar infiltration of neutrophils, levels of myeloperoxidase, oedema formation and CXC c
Introduction: Elderly patients often use many drugs, increasing the risk for drug-related problems. Aim: To optimise drug therapy in the elderly by identifying, resolving and preventing drug-related problems. Methods: (Paper I) Medication reviews were conducted on nursing home patients’ with epilepsy or Parkinson’s disease by a multi-speciality team, whom identified drug-related problems and whe
A theory of self-induced transparency for a TM-mode propagating in a planar semiconductor waveguide sandwiched between two dielectric media is developed. A transition layer between the waveguide and one of the connected media is described using a model of a two-dimensional sheet of quantum dots. Explicit analytical expressions for the optical soliton in the presence of single-excitonic and biexcit
Costimulation blockade can prevent rejection of nerve allografts in short-term studies. We tested if costimulation blockade also prevented rejection of nerve allografts in long-term experiments, thereby improving functional recovery. A 7-mm sciatic nerve defect in C57/BL6 mice was bridged either by nerve allografts from Balb/C mice or by isogenic nerve grafts (isografts) from C57/BL6 mice. Costimu
Surgically revised deep infected primary knee arthroplasties reported to the Swedish knee arthroplasty register during the years 1986-2000 were studied with respect to microbiology, antimicrobial susceptibility pattern and changes over time. In early, delayed and late infections, coagulase-negative staphylococci (CoNS) were most prevalent (105/299, 35.1%), and twice as common as Staphylococcus aur
In social cognitive theory, self‐efficacy is domain‐specific. An alternative model, the cross‐domain influence model, would predict that self‐efficacy beliefs in one domain might influence performance in other domains. Research has also found that children who receive special instruction are not good at estimating their performance. The aim was to test two models of how self‐efficacy beliefs influ
