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Cerebral ischemia induces transcriptional upregulation of inflammatory genes in the brain parenchyma and in cerebral arteries, thereby contributing to the infarct development. The present study was designed to evaluate the involvement of calcium-calmodulin-dependent protein kinase (CaMKII) II and extracellular signal-regulated kinase1/2 (ERK1/2) on inflammatory mediators in rat cerebral arteries u
Structural fire safety in Sweden for one- and two-story assembly hall buildings have been studied with regards to recent concerns regarding a large variation in the interpretation of the regulations and the resulting fire protection of the buildings. The study has been divided into three parts. First, an analysis of the current national regulations and identification of unclear paragraphs has been
Despite several lines of evidence from preclinical and post-mortem studies suggesting that inflammation is involved in Multiple System Atrophy (MSA), no previous studies have measured peripheral indices of inflammation in MSA patients.
Background. Poor ultrafiltration is associated with worse outcomes in peritoneal dialysis (PD) patients. This might in part reflect problems associated with salt and water excess. Increasing the diffusive component of peritoneal sodium removal using low-sodium PD fluids might have beneficial effects on blood pressure (BP), thirst and fluid status that could translate into clinical benefits. Method
Abstract—Service Level Agreements (SLA) are considered a good practice not only for IT outsourcing but also for IT management within an organisation. In this paper we study the usage of SLAs in municipal IT management. Municipal IT management traditionally involves a large organisation, often with a low IT maturity, but with high requirements on software quality and information security. In this s
Background: To examine the association of education with body mass index (BMI) and waist circumference (WC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Method: This study included 141,230 male and 336,637 female EPIC-participants, who were recruited between 1992 and 2000. Education, which was assessed by questionnaire, was classified into four categories; BMI and WC
The aim of the study was to estimate the range of climate variability during the Ferdynandovian climatostratigraphic unit (MIS 13-15). The studied pollen sequences encompass two interglacials (Ferdynandovian I and II - FI and F II), the glaciation separating them (FI/II), the late glacial of the Sanian I (= Elsterian 1) and the early glacial of the Sanian II (=Elsterian 2) and are correlated with
This paper focuses on the role of ISO 14001 in environmental supply management practices in Swedish companies. It discusses the existing and potential role of ISO 14001 for three key operational tasks of environmental supply chain management: to communicate the requirements to the supplier, to motivate and enable the supplier, and to verify that the supplier follows the requirements. The study use
On several occasions during my many years of working with various snake species, I observed a significant positive relationship between body condition and head size (the former calculated from residual scores from a general linear regression of In-transformed mass on In-transformed snout-vent length). Based on results from my long-term study of water pythons (basis fuscus) this relationship is, ho
Transition problems from secondary to tertiary level in mathematics have been a recurrent issue in Sweden. This paper summarises the development during the last decades. Results from two recent research studies that illuminate the transition problem are presented. The first one, based on empirical data from a major Swedish technical university, characterises the widening gap, in content and in app
Despite the vast amount of studies focusing on bone nanostructure that have been performed for several decades, doubts regarding the detailed structure of the constituting hydroxyapatite crystal still exist. Different experimental techniques report somewhat different sizes and locations, possibly due to different requirements for the sample preparation. In this study, small- and wide-angle X-ray s
We compiled literature, intensively studied 15 sites as a group, and collected opportunistically in other areas of the Yosemite National Park. We report a total of 562 species of lichenized fungi from the Park, adding 461 species to the total of 101 species reported for the Park by the National Park Service database. An additional 22 lichenicolous fungi are reported here. Two nonlichenized fungi a
Popular Abstract in Danish Børn og især piger med spændingshovedpine (på engelsk tension-type headache,TTH) har en høj forekomst på verdensplan og betyder for børnene en risiko for skolefravær, medicin over forbrug og vedvarende hovedpine. Den viden, der findes om fysiske faktorers sammenhæng med hovedpine, er begrænset, ligesom viden og dokumentation for interventioner er det. Det overordnede målTension-type headache (TTH) in children and especially girls is a prevalent problem worldwide, and means there is a risk of school absenteeism, medication overuse and persistent headache. Knowledge about the associated physical factors is limited, as is knowledge on evidence based interventions. The overall aim of this thesis was to examine the associations of physical factors with frequent or chr
Background-beta-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to beta-adrenergic stimulation and clinical response to beta-blocker therapy according to mutation location. Methods and Results-The study sample comprised 860 patients with genetically confirmed mutations in the KCNQ1 cha
This report documents the program and the outcomes of Dagstuhl Seminar 13331 "Exponential Algorithms: Algorithms and Complexity Beyond Polynomial Time". Problems are often solved in practice by algorithms with worst-case exponential time complexity. It is of interest to find the fastest algorithms for a given problem, be it polynomial, exponential, or something in between. The focus of the Seminar
The present investigation focus on the receptor Axl, which is a member of the receptor tyrosine kinase family. Axl is activated by the ligand Gas6 inducing cell growth and proliferation, but also regulate inflammation and vascular homeostasis. The Axl receptor can be cleaved outside the membrane, releasing the extracellular, soluble domain, which alone can bind Gas6, removing it from cellbound rec
This article investigates by means of US Patent and Trademark Office (USPTO) patent data whether technological relatedness at the city level was a crucial driving force behind technological change in 366 US cities from 1981 to 2010. Based on a three-way fixed-effects model, we find that the entry probability of a new technology in a city increases by 30% if the level of relatedness with existing t
As with mosquitoes, female tabanid flies search for mammalian hosts by visual and olfactory cues, because they require a blood meal before being able to produce and lay eggs. Polarotactic tabanid flies find striped or spotted patterns with intensity and/or polarisation modulation visually less attractive than homogeneous white, brown or black targets. Thus, this reduced optical attractiveness to t
