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The crystal structures of three conformations, T6, T3R3 and R6, of bovine insulin were solved at 1.40, 1.30 and 1.80 angstrom resolution, respectively. All conformations crystallized in space group R3. In contrast to the T6 and T3R3 structures, different conformations of the N-terminal B-chain residue PheB1 were observed in the R6 insulin structure, resulting in an eightfold doubling of the unit-c
Background. Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of B-cell lymphomas. Five clinical adverse risk factors are merged into the International Prognostic Index (IPI), which is the major tool for prognostication. In contrast to Hodgkin's lymphoma, gender is not considered as an adverse risk factor for DLBCL patients. As we clinically had observed a very good survival rate in y
The problem of estimating the spectral content of exponentially decaying signals from a set of irregularly sampled data is of considerable interest in several applications. for example in various forms of radio frequency spectroscopy. in this paper. we propose a new nonparametric iterative adaptive approach that provides a Solution to this estimation problem As opposed to commonly used methods in
Dinoflagellates are haploid eukaryotic microalgae in which rapid proliferation causes dense blooms, with harmful health and economic effects to humans. The proliferation mode is mainly asexual, as the sexual cycle is believed to be rare and restricted to stressful environmental conditions. However, sexuality is key to explaining the recurrence of many dinoflagellate blooms because in many species
Background: Previous studies have shown that high fiber intake is associated with lower mortality. However, little is known about the association of dietary fiber with specific causes of death other than cardiovascular disease (CVD). Objective: The aim of this study was to assess the relation between fiber intake, mortality, and cause-specific mortality in a large European prospective study of 452
BACKGROUND: Spirometry is used to diagnose chronic obstructive pulmonary disease (COPD). The Impulse oscillometry system (IOS) allows determination of respiratory impedance indices, which might be of potential value in early COPD, although previous experience is limited. We examined pulmonary resistance and reactance measured by IOS in subjects with or without self-reported chronic bronchitis or
P>Aims Type 1 diabetes mellitus (T1DM) is an autoimmune disease with potential mechanistic links to immune-related cancers. We aimed at examining the overall and specific cancer risks among hospitalized T1DM patients from the national registers in Sweden. Methods A T1DM research cohort was created by identifying T1DM patients from the Hospital Discharge Register and linking them with the Cancer Re
Neuron glial 2 (NG2) cells become strongly activated in injured brain areas. The activation is characterized by increased proliferation as well as increased expression and shedding of the proteoglycan NG2 expressed on their cell surface. It is currently not known how these cells respond to low-grade neuroinflammation provoked by systemic inflammation. To investigate this, we analyzed NG2 cell prol
This article outlines a conceptual model that allows a discussion regarding tourist experiences. Through the notion and deconstruction of the concept experience design it is argued that in order to be able to analyze tourism and develop new innovative strategic approaches to tourism management, dynamic notions of space, time and performance have to be especially attended to. This is done through a
Macroscopic properties of metallic materials are to a large extent dictated by the grain size and the presence and arrangement of grain boundaries. Plastic slip deformation will lead to the formation of dislocation pile-ups at grain boundaries, causing a heterogeneous distribution of dislocation density. This will on the macroscale manifest itself as a grain size dependence of the yield stress. Co
Genome-wide association studies (GWASs) help to understand the effects of single nucleotide polymorphisms (SNPs) on breast cancer (BC) progression and survival. We performed multiple analyses on data from a previously conducted GWAS for the influence of individual SNPs, runs of homozygosity (ROHs) and inbreeding on BC survival. (I.) The association of individual SNPs indicated no differences in th
Syftet med denna studie är att beskriva etanols energieffektivitet och klimatnytta och hur dessa parametrar beror av lokala förutsättningar och beräkningsmetodik. Andra aspekter som påverkan på biologisk mångfald, arbetsmiljöförhållanden mm analyseras ej här. Fokus ligger på svensk spannmålsbaserad etanol men kopplingar görs till andra produktionssystem för etanol. Hur klimateffektiv etanol är som
The Canons of Dalby. Three Studies I. When did the brothers in Dalby become Augustinians? There are different opinions among historians about what kind of community Egino founded in Dalby in the late 1060s. Some say it was Benedictine, others say it was a community of canons. Among the latter, some say they were regular canons, others that they were secular, and one distinguished historian has ev
The reaction rate coefficient k(CH3Br + OH) has been determined in the temperature range 298-373 K, using pulse radiolysis/UV kinetic spectroscopy, and at 298 K using a relative rate method. The Arrhenius expression obtained from a fit to the experimental results is (2.9 +/- 0.9) x 10(-12) exp(-(1230 +/- 125)/T) cm(3) molecule(-1) s(-1), which is greater than the expression currently recommended.
We proposed a 4×8 array antenna with aperture-coupled patch antenna elements. The antenna was designed for 60 GHz operation and fabrication on the low-temperature cofired ceramic(LTCC) substrate(εr=5.8). The feedline with the stub was designed to enhance the radiating element bandwidth and the transition characteristics between the waveguide (WG) and microstrip line(MSL). Through the optimization
Popular Abstract in Swedish Gliom är den vanligaste typen av hjärntumörer hos vuxna. Den mikroskopiska klassificeringen av de olika formerna av gliom är subjektiv och i vissa fall t.o.m. felaktig, vilket leder till klinisk oklarhet som kan hindra utvecklingen av terapier som riktas mot speciella egenskaper som kännetecknar speciella typer av gliom. EGFR och PDGFRA är en cellreceptor som har en cenGlioma is the most common type of primary tumor in the adult central nervous system (CNS). However, the current classification of gliomas is highly subjective and even inaccurate in some cases, which leads to clinical confusion and hinders the development of targeted therapies. EGFR and PDGFRA play crucial roles in glia development and glioma pathogenesis. In this thesis we aim to establish a glia
In mammals, including humans, the most consistent cognitive sex difference appears to be a male advantage in spatial ability. Usually, some sex-correlated selective advantage is inferred to explain this, for example, the need for males to navigate over large territories. In birds, sex differences in learning abilities are rare. Here, we show that females of a common European songbird, the great ti
