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The presynaptically located gamma-aminobutyric acid (GABA) transporter (GAT-1) was studied in a group of patients with Alzheimer's disease (AD) and in a control group using the GAT-1 selective radioligand [3H]tiagabine. Post mortem brain tissue from frontal cortex, temporal cortex, and caudate nucleus from 18 AD patients and 23 age-matched controls were studied. The binding was saturable (Kd 26 nM
Bias caused by collecting and processing bulk samples is largely independent of what fossil clade or mineral is searched for. Instead, different methods bias the data to a different, frequently very large, degree. Furthermore, biases accumulate with each recovery step, and the sum may be extreme unless appropriate methods to minimize it are employed. The effects depend on what the data are used fo
I södra sjukvårdsregionen har ett arbete inletts för att kontinuerligt genomföra sakkunniga granskningar (sk peer review) av traumasjukvården inom regionen. I en första granskningsomgång har sex akutsjukhus deltagit. Resultaten har sammanställts i ett granskningsdokument, som gett upphov till såväl uppmärksamhet och diskussion som konkreta åtgärder på det granskade sjukhuset. Granskningsdokument
Study of anti-Thatcherist tendencies in British cinema of the 1980s.
Objective: We assessed the risk of prostate cancer by exposure to Chlamydia trachomatis. Method: Seven hundred thirty eight cases of prostate cancer and 2,271 matched controls were identified from three serum sample banks in Finland, Norway, and Sweden by linkage to the population based cancer registries. Results: A statistically significant inverse association (odds ratio, 0.69; 95% confidence in
High-spin states were populated in Sr-80 With the reaction Ni-58(Si-28,alpha 2p), using a 130 MeV Si-28 beam from the 88-Inch Cyclotron at LBNL. Gamma rays were detected with Gammasphere. and evaporated alphas and protons were detected with the Microball. The level scheme has been extended, and angular distributions of many of the transitions have been measured. A portion of the data was taken usi
Intervju med Paul Verhoeven
Hydrophobic interaction chromatography (HIC) and other capture media are typically produced by grafting different ligands to base matrices at defined surface densities. This often complicates media production. An alternative approach to media involving in situ radical initiated polymerization was used to graft polymer coatings directly at Sepharose(D polymeric base matrices. This method appears su
Background: Gene duplication followed by the functional divergence of the resulting pair of paralogous proteins is a major force shaping molecular networks in living organisms. Recent species-wide data for protein-protein interactions and transcriptional regulations allow us to assess the effect of gene duplication on robustness and plasticity of these molecular networks. Results: We demonstrate t
Using a new channel shape equation for straight channels and a more versatile channel shape or local flow depth equation for natural streams a method is developed for prediction of the longitudinal dispersion coefficient in single-channel natural streams, including straight and meandering ones. The method involves derivation of a new triple integral expression for the longitudinal dispersion coeff
The morphology of cerebral microvessels was studied immunohistochemically and ultrastructurally in 6- to 9-month-old normotensive Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP) with a systolic blood pressure of 138 +/- 15 mm Hg, 189 +/- 9 mm Hg, and 258 +/- 30 mm Hg respectively. Regions with major opening of the blood-brain barrier (BBB) were revealed
The design and properties of a double twin heat conduction microcalorimeter are described. In this instrument two twin microcalorimeters are placed close together, one on top of the other. The size of the instrument is the same as that of a commercial single twin microcalorimeter and each of the twin parts has similar properties as one normal twin microcalorimeter. The cross-talk between the calor
