Filetype
Purpose: Cardiac diffusion tensor imaging (cDTI) can investigate the microstructure of heart tissue. At sufficiently high b-values, additional information on microstructure can be observed, but the data require a representation such as diffusion kurtosis imaging (DKI). cDTI is prone to image corruption, which is usually treated with shot rejection but which can be handled more generally with robus
We consider the averaging process on an infinite connected graph with bounded degree and independent, identically distributed starting values or initial opinions. Assuming that the law of the initial opinion of a vertex has a finite second moment, we show that the opinions of all vertices converge in L2 to the first moment of the law of the initial opinions. A key tool in the proof is the Sharing
We study mixed-integer optimal control problem using indirect approaches. The proposed method relies on splitting algorithms which separate the mixed problem into two solvable pieces and then iteratively alternating between the two. The algorithm gives approximated local solutions, and provides lower and upper bounds estimations of the global optimum. Simulations are provided to validate our appro
Introduction: Cytokine release syndrome (CRS) is a potentially severe systemic inflammatory condition triggered by various immunomodulatory therapies, making understanding its pathogenesis critical for improving patient outcomes. Results/Methods: By combining immunotoxicology and systems biology approaches, we offer a novel and integrative conceptual model of CRS as an adverse outcome (AO), induce
We study the effects of principal instructional leadership on pupil educational achievement using longitudinal data of 120,394 teacher responses across 1919 schools in Sweden over 9 years. Through multilevel structural equation modelling, we test how teacher ratings of principal leadership influence indicators of educational achievement and the extent to which this effect is channelled through a c
The end of what the GDR called “real existierender Sozialismus” in Europe at the beginning of the 1990s dramatically changed the geopolitical situation in Central and Eastern Europe. Five states ceased to exist, whereas 22 new states have been recognized, accompanied by a host of internationally unrecognized states. Nearly half a century of relative stability in Europe was replaced by volatility aThe end of what the GDR called “real existierender Sozialismus” in Europe at the beginning of the 1990s dramatically changed the geopolitical situation in Central and Eastern Europe. Five states ceased to exist, whereas 22 new states have been recognized, accompanied by a host of internationally unrecognized states. Nearly half a century of relative stability in Europe was replaced by volatility a
In an increasingly interconnected and digitalized global world, organizations are confronted with a growing range of complex crises. The COVID-19 pandemic, the war in Ukraine, environmental disasters resulting from climate change, global financial crises, and misinformation campaigns are just some of the contemporary global developments presenting significant organizing challenges. Positioned at t
Background: Because breast cancer (BC) is molecularly heterogeneous, diagnosis and treatment will likely benefit from comprehensive genetic profiling. However, routine, high-resolution sequencing is not feasible yet, due to implementation challenges associated with whole-genome sequencing of formalin-fixed paraffin embedded (FFPE) BC samples. Therefore, we explored the potential of an alternative
A blood biomarker-based staging system for Alzheimer’s disease (AD) could improve the diagnosis, prognosis and identification of individuals most likely to benefit from specific therapies. Here, using targeted mass spectrometry, we measured six phosphorylated and six nonphosphorylated tau peptides in plasma from two independent cohorts: BioFINDER-2 and TRIAD (n = 689). We also analyzed the ratios
The astronomical observations and calculations made at the lunar eclipse of 18 November 1584 in Mexico are analyzed with emphasis on the methods and calculations used. The observations were intended to determine the geographical longitude difference between Mexico City and Seville in Spain but due to several errors, the most important one being using the wrong time for the end of the eclipse in Se
I samband med den väldigt forcerade utbyggnaden av den gröna omställningen genom stora fabriker i norra Sverige ställs en rad frågor kring hanteringen av personal, säkerhet, likabehandling och ansvar. De arbetsrättsliga implikationerna är många. Den ursprungliga euforiska uppfattningen av etableringar som Northvolt i Skellefteå visade sig efterhand föra med sig betydande utmaningar. Texten, som är
Purpose: To evaluate the role of blood perfusion and revascularization during the healing process of periocular defects treated with laissez-faire following tumor excision. Methods: Ten patients with periocular basal cell carcinomas underwent excision, followed by laissez-faire wound management. Blood perfusion was measured using laser speckle contrast imaging postoperatively. Results: Immediately
INTRODUCTION: Large language models (LLMs) have gained increasing popularity in several medical disciplines. In orthopedic research however, their integration into routine practice have been questioned as they do not seem to outperform experienced clinicians. Conversely, research on the role of artificial intelligence in hand surgery remains limited. This study aims to evaluate two common LLMs in
BACKGROUND: Post-acute sequelae of SARS-CoV-2 infection, or long COVID, include diverse symptoms and remain a major concern worldwide. This study investigates the occurrence of depression, anxiety, fatigue, and headache 1 year prior to the COVID-19 pandemic (2019), 12 months prior to, and 6 months after long COVID diagnosis in individuals diagnosed with long COVID and matched population-based cont
Microorganisms are key players in the global cycling of nitrogen and carbon, controlling their availability and fluxes, including the emissions of the powerful greenhouse gases nitrous oxide and methane. Standard sequencing methods often reveal only a limited fraction of their diversity, because of their low relative abundance, the insufficient sequencing depth of traditional metagenomes of comple
