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Background: Right ventricular (RV) function is inadequately investigated and routinely overlooked in transthyretin amyloid cardiomyopathy (ATTR-CM). Novel imaging distinguishers between intrinsic RV myocardial disease in ATTR-CM and primary RV overload disorder phenotypes may enhance mechanistic and pathophysiological understanding of RV dysfunction. We aimed to investigate RV performance in ATTR-
Cancer cells survive treatment through mechanisms that remain unclear. This study investigates the chemical changes that occur in cancer cells after treatment, focusing on lipid metabolism as a potential marker for survival and resistance. Using Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and advanced multivariate statistical analysis, we compared the chemical profiles of untreated a
The photon momentum transfer in the one-photon single ionization (1PSI) of helium is theoretically and experimentally studied. The influence of electron correlations is found to be displayed in the dimensionless photon momentum-transfer factor F, which takes a value of 8/5 for the 1PSI of the 1s state of hydrogen. For the ground state of helium, we find that F first decreases and then increases wi
Dissociation upon sulfur K-shell excitation or ionization of SF6 is studied by sulfur L-shell emission spectroscopy using synchrotron radiation and multiconfiguration Dirac-Hartree-Fock calculations of emission energies and transition rates. The decay path involves in particular Auger emission with the ejection of one or more electrons, leading to singly or multiply charged intermediate states. Ne
OBJECTIVE: Chronic primary prostate pain syndrome (PPPS), usually referred to as chronic prostatitis with chronic pelvic pain syndrome (CP/CPPS), affects approximately 10% of all men. The National Institute of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) was developed for clinical assessment and research evaluation of this patient category. The objective of this study was to translate the N
INTRODUCTION: An increasing number of sub-Saharan African countries are implementing national health insurance schemes (NHISs) to support the aspiration of universal health coverage (UHC). A growing body of literature recognises the private sector role in improving NHIS equity in service access, public provider complementarity and overall member satisfaction. Zambia has implemented the NHIS since
Predicting the evolution of complex systems governed by partial differential equations remains challenging, especially for nonlinear, chaotic behaviors. This study introduces Koopman-inspired Fourier neural operators and convolutional neural networks to learn solution advancement operators for flame front instabilities. By transforming data into a high-dimensional latent space, these models achiev
Given the important role of the land surface for climate, this study aims at (1) to evaluate the quality of the simulation of surface climate by the land-surface component of the EC-Earth3 ESM and (2) to assess the role of the coupling of the land surface with the atmosphere for the simulation of the surface climate in EC-Earth3. It is based on three simulations with different configurations of th
Background: Small airway dysfunction (SAD) is associated with impaired asthma control, but small airway physiology is not routinely assessed in clinical practice. Previously, we demonstrated impulse oscillometry (IOS)-defined small airway dysfunction (SAD) in dual responders (DRs) upon bronchoprovocation with various allergens. Aim: To compare lung physiology using spirometry and IOS following bro
The world of games is no longer a males-only field of cultural leisure and labor practices. Many women and girls, and other marginalized groups, have taken console controls to heart and hands, embraced a variety of computer games and player modes, design games and participate in e-sports. The industry and academy and governmental policies have attempted to help balance the gender equality of the f
Drought is a significant natural hazard that severely challenges water resource management and agricultural sustainability. This study aims to propose a novel approach for predicting streamflow drought indices (SDI-3, SDI-6, and SDI-12) in humid continental (Stockholm) and semi-arid (ELdiem) climates at different time-steps. The approach utilizes a Quantile Regression Neural Network (QRNN) coupled
Occupancy is one of the primary contributors to the energy performance gap, defined as the difference between actual and predicted energy usage, in buildings. This paper limits its scope to residential buildings, where occupant-centric consumption often goes unaccounted for in standard energy metrics. This paper starts from the hypothesis that a simple occupant energy efficiency label is needed to
When parametrizing multi-Higgs potentials, it is desirable to express its coefficients via observables. This is routinely done for the 2HDM, but this approach often fails in more elaborate models. Here, we show that the scalar sector of the CP4 3HDM, an intriguing model based on an order-4 CP symmetry, can also be parametrized in an observable-driven manner. The key feature that makes it work is t
The question of discretion in law is often framed as a technical question – how can we ensure that the decisions produced in administrative processes are accurate, predictable, non-discriminatory, free from bias, etc. If we conceive of discretion with this framing, then replacing human discretion with machine discretion seems eminently sensible.In this article, I question that framing of discretio
The x-ray absorption spectrum of the O2+ molecular cation is measured. The ions are stored in a cryogenically cooled radiofrequency ion trap and probed by tunable synchrotron radiation. The spectrum exhibits several salient features: a three-state composite π∗ resonance at the low-energy side followed by a two-component exchange split, a highly dissociative, σ∗ resonance pulled down well below the
BACKGROUND AND OBJECTIVE: There is no standardized regimen for follow-up after radical cystectomy (RC) for bladder cancer (BC). To address this gap, we conducted a multicenter study involving urologist members from the European Association of Urology (EAU) bladder cancer guideline panels. Our objective was to identify consistent post-RC follow-up strategies and develop a practice-based framework b
We propose and analyze a novel scheme based on LDPC codes for quantitative group testing. The key underlying idea is to augment the bipartite graph by introducing hidden non-binary variables to strengthen the message-passing decoder. This is achieved by grouping items into bundles of size q within the test matrix, while keeping the testing procedure unaffected. The decoder, inspired by some works
Implicit bias interventions, qua attempts to decrease implicit bias measures, are often indirect prejudice interventions. As such, they face a number of potential problems. In particular, implicit bias interventions are more susceptible to generate unforeseen side-effects, are more prone to overcompensation, and less clearly decrease prejudicial behaviour, than at least some direct prejudice inter
