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Polyamines are organic polycations expressed by all living organisms, which are known to play an essential role in cell proliferation and differentiation. Recent studies revealed their involvement also in cell contractility and migration and in programmed cell death. These processes are known to contribute to restenosis, a pathophysiological process occurring in 10-20% of patients submitted to rev
The mereological predicate ‘is part of’ can be used to define the predicate ‘is identical with’. I argue that this entails that mereological theories can be ideologically simpler than nihilistic theories that do not use the notion of parthood—contrary to what has been argued by Ted Sider. Moreover, if one accepts an extensional mereology, there are good philosophical reasons apart from ideological
Objective The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria in order to improve clinical relevance, meet stringent methodology requirements, and incorporate new knowledge regarding the immunology of SLE. Methods The classification criteria were derived from
Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor. In general, tumor growth requires disruption of the tissue microenvironment, yet how this affects glioma progression is unknown. We studied program death-ligand (PD-L)1 in neurons and gliomas in tumors from GBM patients and associated the findings with clinical outcome. Remarkably, we found that upregulation of PD-L1 by neur
To evaluate whether tumor androgen receptor (AR) expression was prognostic and/or predictive for endocrine treatment alone or in combination with estrogen receptor (ER). The AR has been hypothesized to have differential prognostic roles in breast cancer depending on tumor ER-status, and to influence endocrine treatment response.
This work presents the development of a miniaturized system for removing plasma proteins and other low-molecular-weight compounds from red blood cell (RBC) concentrate in a simple one-step-process using integrated ultrasound. The technology utilizes the principles of acoustophoresis to transfer the RBCs from the original plasma-containing solution into a protein-free SAG-M additive solution in a c
Simulations have been carried out by means of computational fluid dynamics for turbulent convective heat transfer in a cross-corrugated plate pattern heat exchanger unitary cell at a Reynolds number of 4930. Chen's high-Reynolds-number k-E model, the Reynolds stress model (RSM), Suga's low-Reynolds-number k-E model, and the V2F model were used. The predicted hydraulic and thermal behaviors using t
The moisture content of wood is commonly determined by measuring the electrical resistance between two electrodes inserted in the wood. However, problems using this method close to wood surfaces were reported in a previous study. In the present study, the effect of the distance to a surface and the specimen size on the measured electrical resistance was studied analytically as follows. The two ele
In this paper we propose a generalised autoregressive conditional heteroskedasticity (GARCH) model-based test for a unit root. The model allows for two endogenous structural breaks. We test for unit roots in 156 US stocks listed on the NYSE over the period 1980 to 2007. We find that the unit root null hypothesis is rejected in 40% of the stocks, and only in four out of the nine sectors the null is
In Alzheimer's disease (AD), placebo-controlled long-term studies of cholinesterase inhibitors (ChEIs) are not permitted for ethical reasons. Therefore, in these studies, patients' outcomes on cognitive and functional assessment scales must be compared with mathematical models or historical data from untreated cohorts. PubMed and previously published long-term extensions of clinical trials and nat
The crystal structure of three incommensurately modulated γ-brass related composite structures in the Pd-Zn-Pt system has been solved from X-ray single crystal diffraction data using a 3 + 1-dimensional super space description. The compounds Pt(x)Pd(15-x)Zn(54) (x ≈ 6, 7, 10) crystallize in orthorhombic superspace group Fmmm(α00)0s0 (F = [(1/2, 1/2, 0, 0); (1/2, 0, 1/2, 0); (0, 1/2, 1/2, 0)] with
A total synthesis of transtaganolide E and F, proposed intermediates in the biosynthesis of the potent transtaganolides, including an Ireland-Claisen rearrangement and a high-pressure intramolecular Diels-Alder cycloaddition reaction of an unactivated 2-pyrone derivative, is reported. The implication of the results to the proposed transtaganolides biosynthesis is discussed.
Between-person differences in white matter microstructure may partly generalize across the brain and partly play out differently for distinct tracts. We used diffusion-tensor imaging and structural equation modeling to investigate this issue in a sample of 260 adults aged 60-87 years. Mean fractional anisotropy and mean diffusivity of seven white matter tracts in each hemisphere were quantified. R
Late Katian (Late Ordovician) carbonate mudmounds in the TuresO Formation, Peary Land, North Greenland, succeed normal marine faunas dominated by brachiopods, bryozoans, cephalopod and gastropod molluscs, aulaceratid stromatoporoids, corals and receptaculitid algae, in the BOrglum River Formation, and are themselves succeeded by organic-rich, largely barren limestones. This peri-Laurentian success
BOLGER, C., E. TUFVESSON, M. SUE-CHU, G. DEVEREUX, J. G. AYRES, L. BJERMER, and P. KIPPELEN. Hyperpnea-Induced Bronchoconstriction and Urinary CC16 Levels in Athletes. Med. Sci. Sports Exerc., Vol. 43, No. 7, pp. 1207-1213, 2011. Purpose: Exercise-induced bronchoconstriction (EIB) is a common condition in both individuals with asthma and otherwise healthy elite athletes. Although excessive water l
A local-scale Gaussian dispersion-deposition model (OML-DEP) has been coupled to a regional chemistry-transport model (DEHM with a resolution of approximately 6 km x 6 km over Denmark) in the Danish Ammonia Modelling System, DAMOS. Thereby, it has been possible to model the distribution of ammonia concentrations and depositions on a spatial resolution down to 400 m x 400 m for selected areas in De
