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Objectives: Genetic variations in TNFAIP3 (A20) de-ubiquitinase (DUB) domain increase the risk of systemic lupus erythematosus (SLE) and rheumatoid arthritis. A20 is a negative regulator of NF-κB but the role of its DUB domain and related genetic variants remain unclear. We aimed to study the functional effects of A20 DUB-domain alterations in immune cells and understand its link to SLE pathogenes

Mechanical stretch under both physiological (breathing) and pathophysiological (ventilator-induced) conditions is known to significantly impact all cellular compartments in the lung, thereby playing a pivotal role in lung growth, regeneration and disease development. In order to evaluate the impact of mechanical forces on the cellular level, in vitro models using lung cells on stretchable membrane

Goals concerning reduced car traffic are found in most European cities, indicating a potential change in local transport policy and land use planning, which have traditionally been very car-centric. This paper analyses goals and measures to reduce car traffic in Swedish municipalities’ long-term transport and land use plans. Theoretically, the paper is based on an understanding of policies as part

Importance: Multiple myeloma is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS). Risk models that estimate the risk of progression from MGUS to multiple myeloma use data from a single time point, usually the initial workup. Objective: To longitudinally investigate the alterations of serum immune markers with stable vs progressive MGUS. Design, Setting, and Partic

Objective: To investigate the antimicrobial activity of peptides derived from C-type Lectin Domain Family 3 Member A (CLEC3A), shed light on the mechanism of antimicrobial activity and assess their potential application in prevention and treatment of septic arthritis. Design: We performed immunoblot to detect CLEC3A peptides in human cartilage extracts. To investigate their antimicrobial activity,

Objective: To update and expand upon prior Osteoarthritis Research Society International (OARSI) guidelines by developing patient-focused treatment recommendations for individuals with Knee, Hip, and Polyarticular osteoarthritis (OA) that are derived from expert consensus and based on objective review of high-quality meta-analytic data. Methods: We sought evidence for 60 unique interventions. A sy

Mango (Mangifera indica L.) is a tropical fruit which is considered to be a source of dietary fiber (DF) and phenolic compounds (PCs). In this study, high DF mango-based fruit bars were developed from whole mango (peel and pulp). The bars were evaluated for their nutritional composition, the bioaccesibility of PCs during gastrointestinal digestion, and the PCs metabolites profile after in vitro co

This thesis focuses on the terminal aspects of massive MIMO systems. Based on the degree of freedom a terminal have in a MaMi, different antenna configurations, transceiver topologies with associated transmission schemes, and the underlying algorithms are researched.The first studied topic concerns multiple-antenna terminals in a massive MIMO system for sub-6 GHz, operated at the center frequency

INTRODUCTION The purpose of this chapter is twofold. First, it aims to provide managers and researchers with a number of concepts and perspectives which are relevant to understanding the evolution of environmental management as a corporate function. Second, in adopting and developing a critical position toward a number of current conventions or common assumptions, it aspires to add something of va

This book is in honour of Professor Anna-Sofia Maurin on her 50th birthday. It consists of eighteen essays on metaphysical issues written by Swedish and international scholars.

AIM: Developing a theory explaining how public health nurses accomplish and adapt counselling in lifestyle habits to decrease obesity in people with mobility disability.DESIGN: Empirical research - qualitative.METHOD: Classic grounded theory with face-to-face interviews, 2017-2018, using inductive approach to understand public health nurses' intervening experiences with obesity patients.RESULTS: T

INTRODUCTION Human resource management (HRM) has an important role to play in corporate environmental management in supporting the success of environmental policies and programmes. Indeed, the sorts of changes advocated in this book are unlikely to succeed without the full support of human resource managers. Equally environmental initiatives and culture change programmes will not succeed without t

If resolving the global environmental cns1s were simply a matter of 'techniques', in other words installing new production technologies, converting to zero-emissions vehicles, using less packaging, changing to 'green' fiscal policies and strengthening emissions laws. then why haven't we already implemented them? The technical principles of a shift to a sustainable society are simple and straightfo