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Today immunohistochemistry (IHC) stains molecular biomarkers for treatment stratification. IHC can become increasingly objective by improving sensitivity, quantification and multiplexing capabilities. We use upconverting nanoparticles to achieve this, potentially leading to improved treatment outcomes.
The Velika Vrbica loess-palaeosol sequence, situated on the south-western bank of the Danube River in northeastern Serbia, represents one of the key Quaternary records in the lower Danube basin, covering the MIS 5-MIS 1 period. Previous investigations of the upper 500 cm established a high-resolution chronology and revealed unexpected patterns of dust accumulation during interstadial phases. In th
A review of Eva Lilja's study on the phenomenon of rythm in modernist poetry and literature. The book also includes some intermedial aspects.
AIMS: Although age-related immune deterioration has been implicated as a mechanistic contributor to cardiovascular disease (CVD), evidence for an impairment of adaptive immune function in individuals with clinically verified presence of atherosclerosis is lacking.METHODS AND RESULTS: To test the association between atherosclerosis and immune function, we evaluated SARS-CoV-2 vaccine responsiveness
Using data on 119 low- and lower-middle-income countries from 2002 to 2020, we fit fixed-effects (FE) models to evaluate the impacts of three types of official development assistance (ODA) on access to three types of sexual and reproductive health (SRH) services: access to skilled birth attendance, access to modern contraceptives and coverage of antiretroviral therapies against HIV/AIDS. The resul
A review on Archaeologist Peter Carelli's study about chess and chess pieces found in Scandinavia during the Middle ages.
Background and purpose — Backside wear of the polyethylene insert in total knee arthroplasty (TKA) has been described to produce clinically significant levels of polyethylene debris, which can lead to aseptic loosening and osteolysis. Monoblock design eliminates backside wear of the polyethylene and therefore could improve long-term fixation. This randomized clinical trial (RCT) using radiostereom
The congenital disorders of glycosylation (CDG) comprise a large and growing family of genetic disorders, characterized by hypoglycosylation of multiple glycoconjugates. Normal glycosylation requires a large number of enzymes and associated proteins acting in sequence to modify proteins and lipids by the addition of oligosaccharide side chains. This process is essential for normal development and
This paper contains an identification key and descriptions in Swedish to the species of Caloplaca s. lat. currently known from theNordic countries.
The particle da- is used in various Arabic dialects to express a range of modal, future, progressive, habitual, optative and final functions. The present article analyzes the use of the particle da- in the dialect of Aleppo, for which it has thus far only been mentioned with a future and modal (want) function. An analysis of already published recordings from Behnstedt, along with one previously un
Abstract in GermanIn dieser Folge spricht Maria del Carmen Moreno Escobar mit Florian Hermann und Adrian Kinzig über ihre Forschung zu römischer Landschaft, Mobilität und Connectivity. Sie zeigt, wie GIS, Fernerkundung und geoarchäologische Methoden helfen, antike Häfen, Verkehrswege und Interaktionsräume zu rekonstruieren – und wie sich historische und archäologische Daten zu einem vielschichtigeIn this episode, Maria del Carmen Moreno Escobar speaks with Florian Hermann and Adrian Kinzig about her research on Roman landscape, mobility, and connectivity. She demonstrates how GIS, remote sensing, and geoarchaeological methods help reconstruct ancient ports, transport routes, and spaces of interaction—and how historical and archaeological data can be combined to create a multifaceted pictur
Academic skills such as reading, writing, critical thinking and information literacy are foundational to university-level learning. However, although students often have a certain level of academic literacy on arrival, their skills do not necessarily match the context-specific requirements of higher education and often need to be explicitly taught. In contrast to
In recent decades, a significant advancement in the Global Navigation Satellite System (GNSS) has been adopting the vector tracking (VT) technique, particularly in environments where stable and reliable positioning is essential. It facilitates rapid reacquisition and continuous tracking of GNSS signals by linking the data processing and signal processing modules. In challenging environments affect
Degenerative diseases related to aging, such as malnutrition, memory loss, and osteoporosis, develop due to a lack of appropriate components required at certain times for protein synthesis. Alpha-ketoglutarate (AKG) is produced by the gut bacteriome and regulates several processes involved in protein metabolism, but mainly ensures the sparing of host nitrogen (amine group) and the synthesis of new
Epilepsy affects approximately 50 million people worldwide, and over 30% of patients are considered treatment resistant to currently available anti-seizure drugs. Neuropeptide Y (NPY) has been shown to inhibit excitatory synaptic transmission in hippocampal slices from human epilepsy patients via Y2 receptors (Y2Rs), and overexpression of NPY and/or Y2R in the hippocampus reduces seizures in roden
