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We describe how to utilize the possibility of differentiating through arbitrary Julia codeto perform tasks such as controller optimization. The user specifies a cost function, forexample, the integrated squared error between output and reference, and constraints, suchas a maximum acceptable value of the sensitivity function. Julia performs the integrationand calculates the sensitivities of the cos
The General Data Protection Regulation (GDPR) came into force in May 2018. The aspiration of providing for a high level of protection to individuals’ personal data risked placing considerable constraints on scientific research, which was contrary to various research traditions across the EU. Therefore, along with the set of carefully outlined data subjects’ rights, the GDPR provides for a two-leve
This study investigated the relationship between perceived indoor temperature in winter and frailty among community-dwelling older people. This cross-sectional study included 342 people 65 years and older in Japan. Participants answered questions about demographics, frailty, housing, and perceived indoor temperature in winter. Participants were grouped based on perceived indoor temperature (Cold o
Although cuprate high-temperature superconductors were discovered already in 1986 the origin of the pairing mechanism remains elusive. While the doped compounds are superconducting with high transition temperatures Tc, the undoped compounds are insulating due to the strong effective Coulomb interaction between the Cu 3d holes. We investigate the dependence of the maximum superconducting transition
5-Hydroxymethylfurfural (HMF), an important biobased platform chemical, can be potentially oxidized to several products that can serve as versatile building blocks for polymers. 5-Hydroxymethyl-2-furan carboxylic acid (HMFCA) is formed by incomplete oxidation of HMF but the reaction often suffers from substrate inhibition and overoxidation
The development of microwave photon detectors is paving the way for a wide range of quantum technologies and fundamental discoveries involving single photons. Here, we investigate the photon emission from a microwave cavity and find that distribution of photon waiting times contains information about few-photon processes, which cannot easily be extracted from standard correlation measurements. The
Many biological data acquisition platforms suffer from inadvertent inclusion of biologically irrelevant variance in analyzed data, collectively termed batch effects. Batch effects can lead to difficulties in downstream analysis by lowering the power to detect biologically interesting differences and can in certain instances lead to false discoveries. They are especially troublesome in predictive m
Computational tools are widely used for interpreting variants detected in sequencing projects. The choice of these tools is critical for reliable variant impact interpretation for precision medicine and should be based on systematic performance assessment. The performance of the methods varies widely in different performance assessments, for example due to the contents and sizes of test datasets.
Background Intracellular delivery of antimicrobial agents by nanoparticles, such as mesoporous silica particles (MSPs), offers an interesting strategy to treat intracellular infections. In tuberculosis (TB), Mycobacterium tuberculosis avoids components of the immune system by residing primarily inside alveolar macrophages, which are the desired target for TB therapy. Methods and findings We have p
he aim of this study was to investigate the acute effect of hydration status on glycemic regulation in healthy adults and explore underlying mechanisms. In this randomized crossover trial, 16 healthy adults (8 men, 8 women) underwent an oral glucose tolerance test (OGTT) when hypohydrated and rehydrated after 4 days of pretrial standardizat
Background: Breathlessness, the subjective sensation of breathing discomfort, is common and appears in the daily life of people with cardiorespiratory diseases. Physicians often rely on patient's history based on symptom recall. The relation between recalled and experienced breathlessness is still poorly understood. This paper presents the protocol for a study primarily aimed at evaluating the rel
Aims. We seek to provide abundances of a large set of light and neutron-capture elements homogeneously analyzed that cover a wide range of metallicity to constrain globular cluster (GC) formation and evolution models. Methods. We analyzed a large sample of 885 GCs giants from the SDSS IV-Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey. We used the Cannon results to separate
Electric road systems (ERS) are designed to transfer power to electric vehicles (EV) while moving, not only for charging the on-board battery, but also for propelling the vehicle and supplying the auxiliary systems. The step from dynamic charging to static charging with a conductive ERS is not large since most of the equipment can be used without modification, yet it brings thermal challenges. Sta
This paper presents and assesses the cooling integration of medium size electrical machines with distributed hair-pin type of windings. By introducing a hollow or profiled conductor the generated heat can be removed right where it is created. The cooling duct in conductor that can be connected either to series or parallel cooling flows increases DC resistance up to 1.5 times when comparing commerc
Electric road systems (ERS) are technologies that allow to charge electric vehicles (EVs) while they are driving. This makes it possible to reduce the installed battery capacity and therefore the weight and cost of the vehicle. However, while the vehicle is charging from the ERS a protective earth connection cannot be ensured, which introduces new isolation challenges in the design of the electric
