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Molecular dynamics simulations, binding free energy calculations, principle component analysis (PCA), and residue interaction network analysis were employed in order to investigate the molecular mechanism of M184I single mutation which played pivotal role in making the HIV-1 reverse transcriptase (RT) totally resistant to lamivudine. Results showed that single mutations at residue 184 of RT caused
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Accurate and efficient evaluation of the stored energy is essential for Q-factors, physical bounds, and antenna current optimization. Here, it is shown that the stored energy can be estimated from quadratic forms based on a state-space representation derived from the electric and magnetic field integral equations. The derived expressions are valid for small antennas embedded in temporally dispersi
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The main aims and goals of this article are to present two assemblages of the Pitted Ware Culture (PWC) in the province of Scania, southern Sweden. One comes from an inland site named Na, located on the northern shore of Lake Ringsjön. Na was excavated in the 1880s. The other site, Jonstorp, is located in north-western Scania and is a coastal site. The sites have historically been connected by a r
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The aims and goals of the article are to discuss how typology can be misleading in the study of archaeological artefacts. The discussion is exemplified using transverse arrowheads in the late Scandinavian Mesolithic. One contemporary, and often accepted, typology of transverse arrowheads is presented along with a summary of typological development and debates. The concept of curation, first introduc