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BRCA1 mutations, although implicated in disease predisposition in a major part of the hereditary breast cancer population, do not seem to be crucially involved in tumorigenesis of sporadic breast and ovarian cancers. This suggests that tumours arising in BRCA1 mutation carriers may differ from BRCA1 negative hereditary and sporadic cancer in genetic and biological features, as well as in clinical
We construct hadronic potentials that describe the spectrum and decays of electromagnetic bound states of hadrons, and are consistent with Chiral Perturbation Theory. This procedure enables one to clarify the status of the calculations-based on potential models-of the electromagnetic corrections to the observables of hadronic atoms and to the strong scattering amplitudes at low energy.
PURPOSE. Adult human corneal epithelial basement membrane ( EBM) and Descemet's membrane ( DM) components exhibit heterogeneous distribution. The purpose of the study was to identify changes of these components during postnatal corneal development. METHODS. Thirty healthy adult corneas and 10 corneas from 12-day- to 3-year-old children were studied by immunofluorescence with antibodies against BM
The benefit of including isoniazid-containing Lowenstein-Jensen medium for primary isolation of mycobacteria was evaluated in 3,726 clinical specimens. This media increased the primary isolation of mycobacteria other than Mycobacterium tuberculosis by 9.2%, facilitated macroscopical reading and aided presumptive identification of the isolated mycobacteria.
The work with the Nordic consensus report on asthma management started some years ago. The Nordic countries have common socioeconomic conditions. We acknowledge the international as well as other European guidelines providing valuable recommendations. Nevertheless, we felt the need to combine the common Nordic experiences in order to have a local statement of asthma and asthma care, based upon Nor
We report on large-scale ab initio multiconfiguration Dirac-Fock (MCDF) calculations for spectral lines of Si IX, with emphasis on the forbidden transitions 2p(2) P-3(J-->J'). The J = 0 --> J' = 1 transition at 3.9346 mu m holds promise as a diagnostic of coronal magnetic fields if and when future coronagraphic instruments can measure the polarized light at this wavelength.
Osmoderma eremita (Scopoli) is an endangered scarab beetle living in hollow trees. It has mainly been known for its characteristic odor, typically described as a fruity, peachlike or plumlike aroma. The odor emanating from a single beetle can sometimes be perceived from a distance of several meters. In this paper, we show that the characteristic odor from O. eremita is caused by the compound (R)-(
This paper presents a semi-empirical combined-slip tiremodel including transient behavior. The method relies on theassumption that the transient behavior is a result from the dynamicdeformation of the tire carcass and that the interaction between thelateral and longitudinal slip and forces can be explained by thedeformation of the rubber treads. The deformation of the tire carcassmakes the tread s
Popular Abstract in Swedish Det ljus som vi vanligen ser, har spritts av objekten i vår omgivning. Ett annat ljusfenomen är fluorescens, som kan användas inom olika områden för analys av prover. Olika substanser ger skilda fluorescensprofiler. Om dessa inte helt överlappar varandra kan substanserna särskiljas. Områden, där ljusdiagnostik har använts inom ramen för detta arbete, är kemisk analys, mIn this thesis spectroscopic techniques have been used in the fields of analytical chemistry, environmental and medical applications. In analytical chemistry, laser induced fluorescence was used to image the separation of substances during capillary electrophoresis. Here, an optical fibre imaging technique facilitated a higher sensitivity compared with a lens imaging technique. The motion of the s
Popular Abstract in Swedish Diffust storcelligt B-celllymfom (DLBCL) är den vanligaste aggressiva lymfomsjukdomen, och drabbar ca 450 personer årligen i Sverige. Med modern antracyklin-innehållande cytostatikabehandling är DLBCL en potentiellt botbar sjukdom. Av patienter med lokaliserad sjukdom botas 70 %, med spridd sjukdom ca 50 %. Bakgrunden till arbete 1 i denna avhandling var en rapport därDiffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoma subtype. In Sweden 450 new cases are diagnosed annually. With modern anthracycline-containing chemotherapy DLBCL is potentially curable, with an estimated overall cure rate of approximately 50% for patients with advanced stage disease. Through molecular profiling of DLBCL the ?cell-of-origin concept? has been established: patients
Objective. To investigate the relationship between PTEN gene expression and differentiation of glioma. Material and methods. The quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) method was applied to detect PTEN mRNA levels in glioma tissues. Tumor-adjacent normal tissues and benign brain tumors were used as controls. Relative PTEN mRNA levels were determined as the
