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High malignancy and early metastasis are hallmarks of melanoma. Here, we report that the transcription factor Snail1 inhibits expression of the tumor suppressor CYLD in melanoma. As a direct consequence of CYLD repression, the protooncogene BCL-3 translocates into the nucleus and activates Cyclin D1 and N-cadherin promoters, resulting in proliferation and invasion of melanoma cells. Rescue of CYLD
Popular Abstract in Swedish Plasma består av fria elektroner, joner och neutrala partiklar och utgör det fjärde tillståndet av materia där de andra tre är fast-, flytande- och gasfas. Plasma är den vanligast förekommande tillståndet av materia i universum och uppskattas utgöra mer än 99% av universums totala massa. Naturligt förekommande plasma återfinner vi i blixtar, sol vinden, jonosfären och iNon-thermal plasma is regarded as a collection of free electrons, ions and neutral particles that are not at local thermodynamic equilibrium. The high-energetic electrons formed in non-thermal plasmas are capable of generating chemically active species and modifying chemical kinetics in practical applications. One promising application of non-thermal plasmas is to achieve plasma-assisted combustio
Community mobility, defined as "moving [ones] self in the community and using public or private transportation", has a unique ability to promote older peoples' wellbeing by enabling independence and access to activity arenas for interaction with others. Early predictors of decreased community mobility among older men and women are useful in developing health promoting strategies. However, long-ter
The stem of Agave tequilana is used to obtain: agave syrup (AS) and native agave fructans (NAF). Ground-agave-fiber is the by-product from fructans production. These ingredients were used to design a food ingredient: agave dietary fiber (ADF), containing NAF (30 g/100 g) as soluble dietary fiber (DF) and ground-agave-fiber (70 g/100 g) as an insoluble DF. The objective of this work was to evaluate
RATIONALE AND OBJECTIVES: To compare differences in diffusion tensor imaging (DTI) and dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance (MR) perfusion imaging characteristics of recurrent neoplasm and radiation necrosis in patients with brain tumors previously treated with radiotherapy with or without surgery and chemotherapy. MATERIALS AND METHODS: Patients with a hist
We report a combination of physical property and neutron scattering measurements for polycrystalline samples of the one-dimensional spin-chain compound CoV2O6. Heat capacity measurements show that an effective S = 1/2 state is found at low temperatures and that magnetic fluctuations persist up to similar to 6T(N). Above T-N = 6.3 K, measurements of the magnetic susceptibility as a function of T an
Long-term records of environmental history at decadal to millennial time-scales enable an assessment of ecosystem variability and responses to past anthropogenic disturbances and are fundamental for the development of environmental management strategies. This study examines the local variability of land-use history in the South Swedish Uplands over the last 200 years based on pollen records from t
Vertebrate leukotriene A(4) hydrolases are bifunctional zinc metalloenzymes with an epoxide hydrolase and an aminopeptidase activity. In contrast, highly homologous enzymes from lower organisms only have the aminopeptidase activity. From sequence comparisons, it is not clear why this difference occurs. In order to obtain more information on the evolutionary relationship between these enzymes and t
Background: Voltage-dependent K+ channels (Kv) mediate repolarisation of beta-cell action potentials, and thereby abrogate insulin secretion. The role of the Kv1.1 K+ channel in this process is however unclear. We tested for presence of Kv1.1 in different species and tested for a functional role of Kv1.1 by assessing pancreatic islet function in BALB/cByJ (wild-type) and megencephaly (mceph/mceph)
Poly(arylene ether sulfone)s carrying various aromatic mono-, di-, and trisulfonated side´chains have been investigated with respect to their nanoscale structure and key membrane properties. Sulfobenzoyl, sulfonaphthoxybenzoyl, disulfonaphthoxybenzoyl, and trisulfopyrenoxybenzoyl side chains were attached to the poly(arylene ether sulfone) main chain by employing different combinations of metallat
Several ecologically and commercially important fish species spend the winter in a state of minimum feeding activity and at lower risk of predation. To enable this overwintering behaviour, energetic reserves are generated prior to winter to support winter metabolism. Maintenance metabolism in fish scales with body size and increases with temperature, and the two factors together determine a critic
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene lead to the disease cystic fibrosis (CF). Although patients with CF often have disturbances in glucose metabolism including impaired insulin release, no previous studies have tested the hypothesis that CFTR has a biological function in pancreatic beta-cells.
Osteoporosis and low bone strength in older people may be due to low bone mass accrual or elevated age-related loss of bone mass. The mechanisms underlying loss of bone mass have long been subjected to research. However, research has only started in the last decade to focus on strategies to increase bone mass:the current opinion is that childhood and adolescence are critical periods for building u
To study and compare the safety of intersection, traffic scientists today typically manually monitor the intersection during several days and count how often certain events such as evasive manoeuvres occur. This is a laboursome and costly procedure. The aim of this thesis is to provide tools that can reduce the amount of manual labour required by using automated video analytics. Two methods for cr
As new systems and applications are introduced for next-generation wireless systems, the propagation channels in which they operate need to be characterized. This paper discusses propagation channels for four types of next-generation systems: (i) distributed Multiple-Input Multiple-Output (MIMO) and Cooperative MultiPoint (CoMP), systems, which require the characterization of correlation between c
