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Based on its outstanding antifungal properties, it is reasonable to believe that fengycin might be efficient to topically treat localized dermatomycoses. Since most of the fungi species involved in the formation of those mycotic skin diseases colonize primarily the stratum corneum (SC), studying the interaction between fengycin and SC-mimicking lipid membranes is a primary step to determine the po
Previously undiagnosed anaemia is common in elective orthopaedic surgical patients and is associated with increased likelihood of blood transfusion and increased perioperative morbidity and mortality. A standardized approach for the detection, evaluation, and management of anaemia in this setting has been identified as an unmet medical need. A multidisciplinary panel of physicians was convened by
This paper presents a 1MHz bandwidth, ΔƩ fractional-N PLL as the frequency synthesizer for LTE. A noise cancellation path composed of a novel hybrid ΔƩ DAC with 9 output bits is incorporated into the PLL in order to cancel the out-of-band phase noise caused by the quantization error. Further, a re-timing circuit is proposed to reduce the nonlinearity in the Charge Pump and provide pulse shaping si
In-situ time-resolved small-angle neutron scattering (SANS) has been applied for the study of the formation of mesoporous silica SBA-15. The advantage of neutron scattering, compared to X-ray scattering, is the possibility to contrast match i.e. highlight certain parts of the sample. Three different solvents with different scattering contrasts were used for each synthesis. Three different silica s
Infiltration of human melanomas with cytotoxic immune cells correlates with spontaneous type I IFN activation and a favorable prognosis. Therapeutic blockade of immune-inhibitory receptors in patients with preexisting lymphocytic infiltrates prolongs survival, but new complementary strategies are needed to activate cellular antitumor immunity in immune cell-poor melanomas. Here, we show that prima
PIM1 is a constitutively active serine/threonine kinase regulated by cytokines, growth factors and hormones. It has been implicated in the control of cell cycle progression and apoptosis and its overexpression has been associated with various kinds of lymphoid and hematopoietic malignancies. The activity of PIM1 is dependent on the phosphorylation of several targets involved in transcription, cell
A search is performed for narrow resonances decaying into WW, WZ, or ZZ boson pairs using 20.3 fb(-1) of proton-proton collision data at a centre-of-mass energy of root s = TeV recorded with the ATLAS detector at the Large Hadron Collider. Diboson resonances with masses in the range from 1.3 to 3.0 TeV are sought after using the invariant mass distribution of dijets where both jets are tagged as a
Damsin (1) is a pseudoguaianolide sesquiterpene possessing potent biological activities, reported as a metabolite of several medicinal plants belonging to the genus Ambrosia together with related compounds. Starting from 1, which can be isolated in good amounts from Ambrosia arborescens, the five natural pseudoguaianolides ambrosin (2), isodamsin (3), 3 alpha-hydroxydamsin (4), 3 alpha-acetoxydams
Caldicellulosiruptor saccharolyticus displays superior H(2) yields on a wide range of carbon sources provided that lactate formation is avoided. Nevertheless, a low lactate flux is initiated as the growth rate declined in the transition to the stationary phase, which coincides with a drastic decrease in the glucose consumption and acetate production fluxes. In addition, the decrease in growth rate
We present data from cathodoluminescence (CL) studies of nanowires (NWs) grown from size-selected gold particles using metal-organic chemical vapour deposition. The NWs in this study all have a GaAs core and are surrounded by a shell of either AlGaAs or GaInP. The spatially and spectrally resolved CL studies were performed in a scanning electron microscope, in a temperature range of 4–300 K. The N
Aim. The clinical utility of digital linear tomosynthesis in musculoskeletal applications has been validated in only a few reports. Technical performance and utility in hip prosthesis imaging have been discussed in technical reports, but no clinical evaluation has been reported. The purpose of the current study was to assess the added clinical utility of digital linear tomosynthesis compared to ra
Background Prognostic information for asymptomatic patients with aortic stenosis (AS) from prospective studies is scarce and there is no risk score available to assess mortality. Objectives To develop an easily calculable score, from which clinicians could stratify patients into high and lower risk of mortality, using data from the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study. Method
Azimuthal decorrelations between the two central jets with the largest transverse momenta are sensitive to the dynamics of events with multiple jets. We present a measurement of the normalized differential cross section based on the full data set ( integral Ldt = 36 pb(-1)) acquired by the ATLAS detector during the 2010 root s = 7 TeV proton-proton run of the LHC. The measured distributions includ
We report the first measurement at the LHC of coherent photoproduction of rho(0) mesons in ultra-peripheral Pb-Pb collisions. The invariant mass and transverse momentum distributions for rho(0) production are studied in the pi(+)pi(-) decay channel at mid-rapidity. The production cross section in the rapidity range vertical bar y vertical bar < 0.5 is found to be d sigma/dy = 425 +/- 10 (stat.) (+
This paper aims to contribute to the knowledge on innovation processes in low- and medium-low-tech industries. Today, industries characterised as high-tech are perceived to be central to economic development, as the research intensity shields them from competition from low-wage countries. This is less the case for low-tech industries, but their economic importance continues to be large, however. I
Azimuthally anisotropic distributions of D-0, D+, and D*+ mesons were studied in the central rapidity region (vertical bar y vertical bar < 0.8) in Pb-Pb collisions at a center-of-mass energy root(S)(NN) = 2.76 TeV per nucleon-nucleon collision, with the ALICE detector at the LHC. The second Fourier coefficient upsilon(2) (commonly denoted elliptic flow) was measured in the centrality class 30%-50
Aim: Experimental cerebral ischemia and organ culture of cerebral arteries induce an increased endothelin ET(B) receptor-mediated contraction. The aim of the present study was to examine if cytokines and growth factors, known to be activated in ischemia, can influence the expression and function of endothelin receptors after organ culture. Methods: Rat middle cerebral arteries were cultured for 24
