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Alzheimer’s disease is a neurodegenerative disorder associated with the aberrant aggregation of the amyloid-β peptide. Although increasing evidence implicates cholesterol in the pathogenesis of Alzheimer’s disease, the detailed mechanistic link between this lipid molecule and the disease process remains to be fully established. To address this problem, we adopt a kinetics-based strategy that revea
Two new conjugated polymers are synthesized based on a novel donor–acceptor–acceptor (D–A–A) design strategy with the intention of attaining lower lowest unoccupied molecular obital levels compared to the normally used D–A strategy. By coupling two thieno-benzo-isoindigo units together via the phenyl position to give a new symmetric benzene-coupled di-thieno-benzo-isoindigo (BdiTBI) monomer as an
Objective: Neuroinflammatory responses are implicated in depression. The aim was to explore whether depression in patients with type 1 diabetes (T1D) was associated with high circulating galectin-3, controlling for metabolic variables, s-creatinine, life style factors, medication, and cardiovascular complications.Design: Cross-sectional.Methods: Participants were T1D patients (n=283, 56% men, age
Catalytic CO oxidation is a seemingly simple reaction between CO and O2 molecules, one of the reactions in automotive catalytic converters, and the fruit-fly reaction in model catalysis. Surprisingly, the phase responsible for the catalytic activity is still under debate, despite decades of investigations. We have performed a simple but yet conclusive study of single crystal Rh and Pd model cataly
Background: Suicide victims have been found to frequently suffer from mental disorders, often more than one, and comorbidity has also been found to be a risk factor for suicide. The aim of the present study was to determine the first disorder and possible subsequent disorders in suicide victims during their lifetimes and to compare their development with the development of mental and alcohol use d
Abstract: The electroweak production and subsequent decay of single top quarks is determined by the properties of the Wtb vertex. This vertex can be described by the complex parameters of an effective Lagrangian. An analysis of angular distributions of the decay products of single top quarks produced in the t -channel constrains these parameters simultaneously. The analysis described in this paper
Charged Higgs bosons heavier than the top quark and decaying via H± → tb are searched for in proton-proton collisions measured with the ATLAS experiment at (Formula presented.) TeV corresponding to an integrated luminosity of 20.3fb−1. The production of a charged Higgs boson in association with a top quark, gb → tH±, is explored in the mass range 200 to 600 GeV using multi-jet final states with on
Quinoline-3-carboxamides (Q compounds) are immunomodulatory compounds that have shown efficacy both in autoimmune disease and cancer. We have in here investigated the impact of one such compound, paquinimod, on the development of diabetes in the NOD mouse model for type I diabetes (T1D). In cohorts of NOD mice treated with paquinimod between weeks 10 to 20 of age and followed up until 40 weeks of
Groundwater is a finite resource that is threatened by pollution all over the world. Shimabara City, Nagasaki, Japan, uses groundwater for its main water supply. During recent years, the city has experienced severe nitrate pollution in its groundwater. For better understanding of origin and impact of the pollution, chemical effects and surface–groundwater interactions need to be examined. For this
Multiple myeloma (MM) is the second most common hematologic malignancy. The disease is characterized by an uncontrolled growth of malignant plasma cells in the bone marrow, producing a monoclonal immunoglobulin (“M protein”) that can be detected in peripheral blood. Clinically, MM is characterized by bone marrow failure, lytic bone lesions, hypercalcemia, and kidney failure. It is preceded by mono
Background Studies on living donors from the donors' perspective show that the donation process involves both positive and negative feelings involving vulnerability. Qualitative studies of living kidney, liver, and allogeneic hematopoietic stem cell donors have not previously been merged in the same analysis. Therefore, our aim was to synthesize current knowledge of these donors' experiences to de
Prediction of the insulating capability of building products in fire conditions would support the product development process. Stone wool insulation is a widely used material in fire barrier constructions. Due to the combustion of its organic content, the temperature inside stone wool can rise above the temperature of the exposed boundary. This temperature rise is difficult to predict. An extensiv
Critical scholars in the business school are becoming increasingly concerned about the impact of their research beyond the confines of academia. This has been articulated most prominently around the concept of ‘critical performativity’. Drawing on semi-structured interviews with critical leadership scholars, this article explores how academics engage with practitioners at the same time as they see
To establish whether incretin hormones affect insulin clearance, the aim of this study was to assess insulin clearance in mice with genetic deletion of receptors for both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), so called double incretin receptor knockout mice (DIRKO). DIRKO (n = 31) and wild-type (WT) C57BL6J mice (n = 45) were intravenously injected
Objectives: Gastrointestinal graft-versus-host disease (GI-GVHD) is a potentially life-threatening complication after hematopoietic stem cell transplantation. Symptoms indicating GI-GVHD motivates endoscopy with biopsy sampling and histopathological confirmation. Optimal extent of endoscopy in children is, however, presently unknown. Therefore, we aimed to evaluate whether biopsies from the rectos
Abstract: A search is presented for a new, light boson with a mass of about 1 GeV and decaying promptly to jets of collimated electrons and/or muons (lepton-jets). The analysis is performed with 20.3 fb−1 of data collected by the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a centre-of-mass energy of 8 TeV. Events are required to contain at least two lepton-jets. This
