Filetype
Rationale: Clinical interest in psilocybin-assisted rehabilitation for motor disorders is growing. However, psilocybin’s motor effects are under-researched, and quantifying them is essential for assessing treatment risks and outcomes. Objectives: This study aims to clarify whether acute effects of psilocybin disrupt established patterns of manual dexterity and coordination. Specifically, we evalua
Background Since its emergence, the COVID-19 infection has led to significant morbidity and mortality worldwide. Early identification of patients at risk for severe disease is essential for more effective triage, timely therapeutic intervention, and optimal resource allocation. Differences in population characteristics may contribute to variability in disease outcomes, which emphasizes the need fo
Perceived safety in urban areas depends on factors operating across multiple spatial scales. Nevertheless, most studies address only one scale at a time. The methodological contribution of this work lies on the introduction of a multi-scale approach for the analysis of perceived in urban areas. This approach includes city, neighbourhood, and individual scales. The overall goal is to identify the k
Study region: The Limpopo River Basin (LRB) is a transboundary catchment in Southern Africa spanning South Africa, Botswana, Zimbabwe, and Mozambique. The lower basin, particularly the Chókwè–Xai-Xai floodplain in Mozambique, is highly flood-prone due to flat topography, climate variability, and rapid agricultural and settlement expansion. Study focus: This study presents a climate-informed framew
We used national Swedish registry data to investigate the nature of the association between pregnancy and decreased risk for suicide attempt (SA). Analyses included pregnant individuals aged 18–35, biological fathers, and matched controls born 1975–1995. Data were available for between 366,125 and 2,129,244 females (depending on the model) and 359,622 males. We evaluated risk for SA as a function
This exploratory study presents an objective and consistent approach for assessing forest structure across multiple European countries, focusing on the distributions of tree species and tree diameter at breast height (DBH) as assessed by European National Forest Inventories (NFIs) and one landscape inventory. We distinguish six structural classes, ranging from mono-specific plots with a narrow (re
Introduction – Post-acute sequelae of SARS-CoV-2 (PASC) may develop after SARS-CoV-2 infection and cause a wide range of symptoms that can persist for years. Several pathophysiological mechanisms have been proposed, including dysregulation of the complement system. Methods – In this study, we analysed markers of complement activation in a cohort of patients with PASC, up to 33 months after the ini
Background: The participation of nurse leaders in decision-making has been described as vital for healthcare organisations. However, their involvement in health policy-making is still suboptimal and their contribution is frequently unnoticed. This study aimed to understand the contribution of nurse leaders in decision and policy-making during the COVID-19 pandemic to inform future health crisis ma
Breast density, defined as the proportion of breast tissue composed of dense fibroglandular tissue, is a crucial factor in assessing breast cancer risk and significantly impacts the visibility of lesions during mammography screening. We focus on distinguishing between high and low breast density by fine-tuning deep neural networks and on our joint deep and sparse approximation methodology. We eval
Urban vegetation is a critical nature-based solution for mitigating the urban heat island effect, yet its cooling efficacy on road surfaces varies spatially due to differences in vegetation type, structure, and local urban morphology. This study investigates the spatially varying nonlinear cooling effects of differentiated street greenery, including trees, shrubs, and grass, on land surface temper
Trace elements are persistent contaminants that enter bee diets through pollen, nectar, soil-derived particles and atmospheric deposition, yet field-based exposure data for pollinator taxa remain limited. We examined 18 trace elements (Al, As, Ba, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Mo, Ni, Pb, Se, U, V, Zn) in pollen stored by managed western honey bees (Apis mellifera), buff-tailed bumble bees (Bomb
Background: Policy implications are seldom more than a paragraph or two at the end of empirical papers. The aim was therefore to explore social determinants of mental health across life through qualitative analysis of meta-synthesis of empirical publications from a 27-year school-leaver cohort. From the actionable empirical results, we suggest policies for primary prevention aimed at equitable men
Incretins such as glucagon-like-peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) play crucial roles in postprandial glucose management. Glucagon-like-peptide 1 and GIP stimulate insulin release in conjunction with meals and are responsible for up to 75% of the insulin secretion. Incretins are therefore very important for maintenance of normal blood glucose levels. Dairy foo
Parametric uncertainty can hinder land surface models (LSM) from accurately simulating carbon fluxes, such as gross primary production (GPP). These models generally cannot capture inter–annual variability (IAV) of fluxes well due to missing processes, and temporally varying parameters can partially alleviate this limitation. We evaluated this assumption using two models: a light-use efficiency (LU
Sweden faces persistent affordable housing shortages while simultaneously experiencing elevated office vacancy rates. Given that the building sector accounts for roughly one third of global energy demand and two fifths of energy-related greenhouse gas emissions, adaptive reuse presents a promising strategy for mitigating emissions while addressing housing needs. This study investigated the greenho
Accurate mapping of aboveground biomass (AGB) in mountainous forests is essential for carbon stock assessment and ecological management, yet remains challenging due to the difficulty of linking local high-precision observations with regionally continuous coverage. To address this issue, we developed a hierarchical framework integrating local reference construction, UAV–GEDI bridging, footprint-lev
Objectives: Causes of pharyngotonsillitis in Africa, beyond Streptococcus pyogenes, are poorly understood. We aimed to describe the prevalence of S. pyogenes, Fusobacterium necrophorum, and Streptococcus dysgalacatiae subspecies equisimilis (SDSE) in children in The Gambia and evaluate the usefulness of clinical decision rules, originally developed for S. pyogenes or beta-haemolytic streptococci,
Background: Target volume and organ of interest (OOI) contouring and treatment planning for IDH-mutated gliomas CNS WHO grades 2 and 3 are subject to interindividual variation. We aimed to assess this variation and heighten delineation awareness as a quality assurance measure in the PRO-GLIO trial. Methods: Five experts established consensus delineations for target volumes and defined OOI in two I
Background: Wearables increasingly quantify mobility after total knee arthroplasty (TKA), but local joint inflammation is still evaluated intermittently. It is unknown whether the interaction between knee temperature and free-living activity predicts recovery. Objectives: To determine whether early thermo-mobility coupling (TMC), defined as the temporal relationship between peri-patellar skin temp
Detecting small leakages in thermodynamic cooling systems is a critical challenge in modern industrial applications, particularly in large-scale systems such as HVDC installations. Even minor leakages can reduce efficiency, increase energy consumption, and lead to higher maintenance costs. Detecting small leakages is difficult, because of complex system behavior, measurement noise, and natural var
