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Objectives To compare beta-lactam monotherapy versus clindamycin or addition of metronidazole in patients with peritonsillar abscess (PTA). Methods This population-based, retrospective cohort study compared treatment with beta-lactam monotherapy (reference) with clindamycin or addition of metronidazole in patients with PTA during 2013–2020 in the Skåne region, Sweden. The primary outcome was a com
Background: Adjunctive corticosteroid therapy appears to be beneficial for adults with severe community-acquired pneumonia (CAP), but data on Mycoplasma pneumoniae CAP are limited. This study aimed to evaluate if adjunctive betamethasone reduced time to resolution of hypoxaemia in adults hospitalised with M. pneumoniae CAP. Methods: An open-label, multicentre, randomised, controlled trial was cond
Genetic variants in the DNA polymerase enzymes POLE and POLD1 can affect protein function by altering stability, catalysis, DNA binding, and interactions with other biomolecules. Understanding the structural basis of these variants is important for a comprehensive interpretation of variant impact. In this study, we used MAVISp, a modular structure-based framework, and molecular dynamics simulation
Penile prosthesis implantation (PPI) is an effective treatment for refractory erectile dysfunction (ED), but changes in penile length after surgery remain a major determinant of patient satisfaction. We aimed to identify patient- and surgery-related factors associated with final penile length, measured as total implanted device length. We analysed prospectively collected data from the PHOENIX regi
Community energy (CE) is increasingly discussed as a democratic alternative to centralized energy systems, yet its forms and effects vary substantially across national contexts. This article compares CE developments in Germany and Sweden, two countries with ambitious climate agendas but contrasting energy-governance arrangements. The paper examines how institutional frameworks, political cultures,
Objective Large population-based studies that could identify risk factors associated with sepsis mortality are scarce, but could be helpful in clinical risk assessments. With this study, the authors aimed to examine possible risk factors for sepsis mortality. Methods The authors conducted an open nationwide cohort study, including 157,143 individuals aged ≥ 18-years diagnosed with (first event) se
Background: Pain is a common non-motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective: The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation-related pain when added to levodopa therapy in PD patients. Methods: Patients with PD with end-of-dose motor fluctuations and associated pain were randomized
Controlling the three-dimensional topology of single-chain nanoparticles (SCNPs) remains a central challenge in polymer and protein chemistry, particularly for intrinsically disordered systems lacking defined secondary structure. Here, we demonstrate that selective enzymatic intramolecular cross-linking can encode topologically biased interactions in an intrinsically disordered protein (IDP), yiel
This study introduces a novel contrast modality in neutron imaging, enabling the visualization of plastically deformed zones within ARMCO® iron. Utilizing differences in transmitted neutron intensity, we exploit variations in Bragg diffraction strength between deformed and non-deformed areas. Our findings reveal that deformed regions exhibit stronger diffraction due to extensive sub-grain division
Ever since the introduction of the concept of affordance, a debate has continued about how this concept captures the diversity of action possibilities triggered by our environment. One facet of this debate concerns the individual specificity, hence societal diversity, regarding how affordance changes as life changes, such as when we get older. Affordance, or action possibility actualized in the mo
BACKGROUND: High body mass index (BMI) accounts for approximately 7% of total mortality in Sweden and represents a major global public health challenge. In recent years, new anti-obesity medications (AOMs) have been introduced; however, knowledge about how primary care physicians (PCPs) perceive these medications in clinical practice is limited. Understanding PCPs' perspectives is essential as the
Breast density impacts cancer detection by masking tumors within fibroglandular tissue and there are disparities in screening outcomes across racial groups. However, it remains unclear whether these differences reflect inherent tissue characteristics or systemic bias. To isolate the effect of breast density on lesion detectability across racial subgroups, we conducted a retrospective case-control
Background The absolute and relative risk of venous thromboembolism (VTE) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) remains largely unexplored. We conducted a nationwide cohort study to explore this. Objectives To calculate risk of developing VTE among MASLD. Methods This nationwide, population-based matched cohort study in Sweden included all individuals
The Ora Banda structure in Western Australia is situated within an Archean greenstone terrane known for orogenic gold deposits. It is defined by concentric gravity anomalies up to 4 km in diameter, and gravity and passive seismic data indicate the presence of a central uplift and annular trough. Shatter cones were found in surface samples and drill core during gold exploration. Breccia samples fro
Background: Females consistently demonstrate greater tau Positron Emission Tomography (PET) tracer signal. Although interpreted as reflecting greater Alzheimer disease (AD) pathology, it’s unclear whether differences arise from biological mechanisms or methodological factors. Microtubule binding region tau species containing residue 243 (MTBR-tau243) in cerebrospinal fluid (CSF) is a biomarker of
School absenteeism is linked to adverse academic, social, and mental health outcomes, yet few early interventions have been tested in Nordic contexts. This pilot study examined the preliminary effectiveness of the Early Absenteeism Guide for Lifelong Education (EAGLE), a school initiated, parent-focused intervention targeting emerging absenteeism among children. Nine students in preschool to third
Background: Finding new ways of treating bacterial infections is essential. The NlpD protein, which inhibits RNA polymerase II (Pol II), has shown therapeutic efficacy against urinary tract infection. This study investigated the mechanism of Pol II inhibition and protection by NlpD and its LytM peptide. Methods: Recombinant NlpD and LytM were screened for interactions with constituents of the Pol
Urinary tract infections offer an important and highly relevant model to understand innate immune-mediated protection against mucosal infection and innate immune genetics of susceptibility, including promoter polymorphisms reducing Toll-like receptor (TLR) and interferon regulatory factor expression. Whereas virulent Escherichia coli causes severe, potentially life-threatening disease by breaking
People with peripheral arterial disease (PAD) of the lower limbs are at very high risk of cardiovascular events and therefore the cornerstone of their management is medical therapy and behaviour modification to reduce that risk. The risk of limb loss (through major amputation) is low in people with asymptomatic PAD or intermittent claudication with only a few patients progressing to the most sever
The aim of this study was to evaluate one-year clinical performance and safety of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis (VBX Stent Graft) used as a bridging stent in fenestrated and branched endovascular aortic repair (FEVAR and BEVAR). This narrative review summarizes one-year outcomes from two multicenter European registries, EXPAND and EMBRACE. Outcomes are presented separate
