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INTRODUCTION: We evaluated associations between phosphorylated au 217 (p-tau217), p-tau181, p-tau231, and vascular risk factors with cognitive outcomes across the Alzheimer's disease (AD) continuum. METHODS: Baseline plasma p-tau concentrations and vascular risk factors were assessed in 277 Consortium for the Early Identification of Alzheimer's Disease–Quebec (CIMA-Q) participants. Associations be
We provide the first comprehensive analysis of the origin of two enigmatic Satyrinae genera of uncertain affinities. Calisto Hübner, the only Satyrinae genus from the West Indies and endemic to these islands, has resisted numerous attempts at phylogenetic placement, regardless of the data type or methods used. Llorenteana Viloria & Luis-Martínez, a monotypic genus from northwestern Mexico, has
The authors note that Table S8 in the SI Appendix appeared incorrectly. The SI Appendix has been corrected online.
We describe factors to consider when establishing collaborative research projects with agricultural growers, issues that can arise in establishing these relationships, and key steps that researchers can take to improve collaborations and increase the likelihood of project success. We conclude that the most important features of successful collaborations between researchers and agricultural coopera
Scientific integrity and consensus rely on the peer review process, a defining feature of scientific discourse that subjects the literature forming the foundation of credible knowledge in a scientific field to rigorous scrutiny. However, there is surprisingly little training in graduate school on how to develop this essential skill [Zimmerman et al., 2011] or discussion of best practices to ensure
For the 1980-2003 period, we analyzed the relationship between crop yield and three climatic variables (minimum temperature, maximum temperature, and precipitation) for 12 major Californian crops: wine grapes, lettuce, almonds, strawberries, table grapes, hay, oranges, cotton, tomatoes, walnuts, avocados, and pistachios. The months and climatic variables of greatest importance to each crop were us
The magnitude of future climate change depends substantially on the greenhouse gas emission pathways we choose. Here we explore the implications of the highest and lowest Intergovernmental Panel on Climate Change emissions pathways for climate change and associated impacts in California. Based on climate projections from two state-of-the-art climate models with low and medium sensitivity (Parallel
We investigated carbon cycling and ecosystem characteristics among two prairie restoration treatments established in 1987 and adjacent cropland, all part of the Conservation Reserve Program in southwestern Wisconsin, USA. We hypothesized that different plant functional groups (cool-season C3 vs. warm-season C4 grasses) between the two prairie restoration treatments would lead to differences in soi
Most research on the agricultural impacts of climate change has focused on the major annual crops, yet perennial cropping systems are less adaptable and thus potentially more susceptible to damage. In regions where perennial crops are economically and culturally important, improved assessments of yield responses to future climate are needed to prioritize adaptation strategies. These impact assessm
We measured carbon (C) stocks and fluxes and vegetation phenology in the world's oldest prairie restoration (∼ 65 years) and an adjacent prairie remnant in southern Wisconsin from 2001-2004 to quantify structural and functional differences. While the species distributions and frequency differed, the number of species measured per 1m2 were not significantly different (15.8 ± 4.4 and 14.1 ± 2.1 for
The wine industry is increasingly recognized as especially vulnerable to climate change due to the climate sensitivity of both winegrape yields and quality, making it an important model system for the agricultural impacts of global changes. However, agricultural production is strongly influenced by the management decisions of growers, including their practices to modify the microclimate experience
Small Modular Reactors (SMRs) are rapidly emerging as a contributing solution for future fossil-free energy systems globally including Sweden. While SMRs are expected to offer greater flexibility, lower costs, and reduced risks compared to traditional large-scale nuclear reactors, they still present radiological risks. The introduction of SMRs may require new approaches to emergency preparedness (
Reinforcement Learning (RL) has long been a powerful solution to various problems in communication networks. However, traditional RL models still face several limitations. Not only do they rely on large numbers of interactions with the environment, but they are also limited in terms of modeling long-term relationships and tackling partial observability. In recent years, the Transformer model has d
BACKGROUND AND PURPOSE: The experience of having a child monitored for vital signs in relation to surgery for congenital heart disease can be highly stressful for parents. The opportunity to be involved in their child's care is central to parents' well-being and to their overall experience of the care provided. The purpose of this study was to explore how parents of children with congenital heart
Growing evidence shows that air pollution exposure plays a critical role in the development and progression of cardiovascular disease. Pollutants such as airborne particles smaller than 2.5 μm (PM2.5) are linked to systemic inflammation, oxidative stress and vascular dysfunction, thereby increasing the risk of hypertension, atherosclerosis, stroke and myocardial infarction. Understanding the patho
PURPOSE: To describe healthcare professionals lived experiences of being nudged to use transcutaneous electrical nerve stimulation (TENS) in post-anesthesia care.DESIGN: Descriptive phenomenological study.METHODS: A 12-week transparent, passive and asynchronous nudge strategy was implemented in a 15-bed surgical recovery ward where healthcare professionals were exposed to rotating posters to encou
BACKGROUND: Previous cross-sectional studies report an association between psychological distress and severity of pain and symptoms in patients with longstanding non-arthritic hip and groin pain (LHGP). However, there is a lack of longitudinal studies exploring changes in psychological distress over time, and whether these changes relate to changes in pain and symptoms in LGHP patients. This study
Fiscal and monetary policy in the euro area stand at a crossroads. The rules- based framework established in the 1990s—the Maastricht Treaty and the Sta- bility and Growth Pact—has failed to prevent the steady accumulation of public debt, which now stands closer to 90% of GDP than to the Treaty’s 60% ceiling. Successive crises have pushed member states beyond the fiscal limits, while the European
