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Recently, the anticancer activity of human a-lactalbumin made lethal to tumor cells (HAMLET) has been linked to its increased membrane affinity in vitro, at neutral pH, and ability to cause leakage relative to the inactive native bovine alpha-lactalbumin (BLA) protein. In this study, atomic force microscopy resolved membrane distortions and annular oligomers (AOs) produced by HAMLET when deposited
Dendrochronological analysis was applied to subfossil remains of Scots pine (Pinus sylvestris L.) buried in a South Swedish peat deposit. In combination with peat stratigraphy, this approach was explored for its potential to provide information on the local hydrological and depositional history at the site, forming the basis for a regional palaeohydrological analysis. A 726-year ring-width chronol
We explore the emergence of two contemporary mega water projects in Turkey that are designed to meet the demands of the country's major urban centers. Moreover, we analyze how policy makers in the water sector frame problems and solutions. We argue that these projects represent a tendency to depoliticize water management and steer away from controversial issues of water allocation by emphasizing l
Our existing urban environment has a significant potential to increase the use of renewable energy, mainly by using solar irradiation for heat and electricity. Quantification of the solar potential by means of a solar map is the first step in the acceleration process for using more solar energy in our urban environments. A solar map is a GIS system providing the annual solar irradiation on buildin
Background: A strong association has been shown between high viral DNA load (VL) of human papillomavirus (HPV) type 16 and risk for cervical cancer in situ (CIS). However, little data is available for the significance of VL in invasive squamous cell carcinoma (SCC). Methods: In 2 nested case-control studies among women participating in cervical screening, with a cytologically normal first smear, w
Review of David Lowe & Tony Joel. Remembering the Cold War: Global Contest and National Stories. 2014.
Background: We have previously reported that a one-year school-based exercise intervention program influences the accrual of bone mineral in pre-pubertal girls. This report aims to evaluate if also hip structure is affected, as geometry independent of bone mineral influences fracture risk. Methods: Fifty-three girls aged 7-9 years were included in a curriculum-based exercise intervention program c
Background: FUS, EWS and TAF15 are structurally similar multifunctional proteins that were first discovered upon characterization of fusion oncogenes in human sarcomas and leukemias. The proteins belong to the FET ( previously TET) family of RNA-binding proteins and are implicated in central cellular processes such as regulation of gene expression, maintenance of genomic integrity and mRNA/microRN
This Letter reports a search for a heavy particle that decays to WW using events produced in pp collisions at root s = 7 TeV. The data were recorded in 2011 by the ATLAS detector and correspond to an integrated luminosity of 4.7 fb(-1). WW -> lvl'v' (l,l' = e or mu) final states are considered and the distribution of the transverse mass of the W W candidates is found to be consistent with Standard
This paper presents a 2.45 GHz wake-up receiver front-end intended for use in sensor networks, and is designed to receive data modulated with on-off-keying. Manufactured in 65 nm CMOS it employs an uncertain IF structure with three phase passive mixer and high gain amplifier chain. With the modulation frequency response tailored to the detector behaviour, it achieves a sensitivity of -88 dBm at BE
Chromosomal instability is a known hallmark of many cancers. DNA polymerases represent a group of enzymes that are involved in the mechanism of chromosomal instability as they have a central function in DNA metabolism. We hypothesized that genetic variation in the polymerase genes may affect gene expression or protein configuration and by that cancer risk and clinical outcome. We selected four gen
This study explored frail older adults' overall experience of receiving health care and/or social services. Frail older adults with unstable health are dependent on the health care system because of the frequency of their contacts with it. More knowledge is needed about how they experience the health care and social services they receive. Interviews with 14 older adults (mean age = 81) revealed on
This paper presents the Gothenburg Population Panel (GOPP), a random sample of individuals who were living in Gothenburg at some point in time during the period 1915-1943. The individuals in the GOPP were searched for every fourth year in the registers of local tax authorities. The hit rate was high; 95 percent of the individuals and 87 percent of the possible observations in the initial master sa
We have used X-ray photoelectron spectroscopy to study the adsorption of L-cysteine on a rutile TiO2(110) surface at room temperature and -65 degrees C. For the molecules in direct contact with the surface our results suggest that the molecules bind dissociatively to the fivefold-coordinated Ti atoms of the surface through their deprotonated carboxylic groups. A second, dissociative interaction oc
Molecular classification of breast cancer (BC) identified diverse subgroups that encompass distinct biological behavior and clinical implications, in particular in relation to prognosis, spread, and incidence of recurrence. Basal-like breast cancers (BLBC) compose up to 15% of BC and are characterized by lack of estrogen receptor (ER), progesterone receptor (PR), and HER-2 amplification with expre
The Mar del Plata International Water Conference provided the first global assessment of the water sector. It was found that in most developing countries the state of water supply and sanitation services were deplorable. Consequently, a call for concerted action to improve coverage and efficiency of the water supply and sanitation sector was launched. This call resulted in the International Water
