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Complement evasion by various mechanisms is important for microbial virulence and survival in the host. One strategy used by some pathogenic bacteria is to bind the complement inhibitor of the classical pathway, C4b-binding protein (C4BP). In this study, we have identified a novel interaction between nontypeable Haemophilus influenzae (NTHi) and C4BP, whereas the majority of the typeable H. influe
Excessive bleeding impairs outcome after coronary artery bypass grafting (CABG). Current guidelines recommend withdrawal of clopidogrel and ticagrelor 5 days (120 h) before elective surgery. Shorter discontinuation would reduce the risk of thrombotic events and save hospital resources, but may increase the risk of bleeding. We investigated whether a shorter discontinuation time before surgery incr
Objective. To explore how individuals with SSc manage their work life.Methods. We conducted four focus group interviews, which included 17 patients currently working at least 20 h per week. The interviews were recorded and transcribed verbatim. The transcribed texts were analysed according to thematic content analysis. Relevant statements that generated preliminary categories were identified, afte
Portrayals of fictional scientists influence how the public perceive real scientists, and fictional scientists might serve as role models as well as inspire career choices. Crime fiction is probably the most popular fiction genre today, and fictional scientists are an important presence in the genre. This is an exploratory study of three well-known contemporary women crime fiction scientists, take
Ribosomal RNAs contain numerous modifications at specific nucleotides. Despite their evolutionary conservation, the functional role of individual 2'-O-ribose methylations in rRNA is not known. A distinct family of small nucleolar RNAs, box C/D snoRNAs, guides the methylating complex to specific rRNA sites. Using a high-resolution phenotyping approach, we characterized 20 box C/D snoRNA gene deleti
ABSTRACT: BACKGROUND: Individuals with autism spectrum disorders (ASDs) often display symptoms from other diagnostic categories. Studies of clinical and psychosocial outcome in adult patients with ASDs without concomitant intellectual disability are few. The objective of this paper is to describe the clinical psychiatric presentation and important outcome measures of a large group of normal-intell
CREB3L2 encodes a member of the CREB3 family of transcription factors. We characterized its promoter region, showing that it is asymmetrically bidirectional, also driving the expression of a variant of AKR1D1. It has a CRE binding site which is conserved among mammalians; removal or alteration of it resulted in reduced promoter activity. When transiently transfecting the HEK293 cell line with cons
We examined the relation between nutrient-stimulated insulin secretion and the islet lysosome acid glucan-1,4-alpha-glucosidase system in rats undergoing total parenteral nutrition (TPN). During TPN treatment, serum glucose was normal, but free fatty acids, triglycerides, and cholesterol were elevated. Islets from TPN-infused rats showed increased basal insulin release, a normal insulin response t
The aim of this thesis is to describe the conceptual structure of space and its relationship to semantics. It is a further aim to explain differences between German and Swedish verbal expressions of space, in which one language requires a directional and the other a static prepositional phrase. This is the case with causative positional verbs, many applicative verbs, certain verbs expressing arriv
Encountering waves overtaking a ship sailing on the ocean may cause instability. Therefore it is of great importance to study the properties of such waves, for example slope, wavelength and amplitude. When making statistics on the properties of overtaking waves, only the waves that are faster than the ship will affect the resulting distribution. Thus the velocity of the individual waves plays an i
