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Opioid receptor-binding autoradiography was used as a way to map sites of altered opioid transmission in a rat model of L-DOPA-induced dyskinesia. Rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathways sustained a 3-week treatment with L-DOPA (6 mg/kg/day, combined with 12 mg/kg/day benserazide), causing about half of them to develop dyskinetic-like movements on the side of t
Transplants of fetal midbrain raphe neurons into the adult brain have been shown to promote recovery of complex behavioral deficits in several experimental models, but the mechanisms underlying these effects are only partially understood. In the present study, we have used a well-characterized model system to ascertain whether midbrain raphe graft can display behaviorally relevant changes in trans
Objective: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises one quarter of all ischemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neuro
We investigated the role of dopamine neurons in the manifestation of levodopa-induced dyskinesia in a rat model of Parkinson's disease. Daily treatment with a subthreshold dose of levodopa gradually induced abnormal involuntary movements (AIM) in 6-hydroxydopamine-lesioned rats, which included stereotypy and contraversive rotation. After 4 weeks of levodopa treatment, rats with mild and severe AIM
Childhood obesity is a serious public health problem in Mexico. In this study, childhoodspecific dietary patterns and their relationship with overweight-obesity prevalence, nutrient profiles and types of foods consumed were studied. A descriptive cross-sectional study of 724 randomly selected schoolchildren between 9 to 12 years old from Nayarit State, Mexico was performed. Data on anthropometric
In disease dynamics, high immune gene diversity can confer a selective advantage to hosts in the face of a rapidly evolving and diverse pathogen fauna. This is supported empirically for genes involved in pathogen recognition and signalling. In contrast, effector genes involved in pathogen clearance may be more constrained. b-Defensins are innate immune effector genes; their main mode of action is
The polymer electrolyte fuel cell (PEFC) is considered as one of the most promising devices for providing efficient, clean and noiseless conversion of chemical energy to electrical energy. This device can provide electrical and thermal energy for transport, mobile and stationary applications ranging in a wide range of power requirements. However, in spite of its promising potential and increasing
BACKGROUND: The objective of this study was firstly to develop and evaluate an automated method for the detection of new lesions and changes in bone scan index (BSI) in serial bone scans and secondly to evaluate the prognostic value of the method in a group of patients receiving chemotherapy.METHODS: The automated method for detection of new lesions was evaluated in a group of 266 patients using t
In recent years, the awareness of academic misconduct has increased due to high-profile scandals involving prominent researchers and a spike in journal retractions. But such examples of fabrication, falsification, and plagiarism (FFP) serve to obscure the less flagrant, more subtle cases of possible misconduct: what some have called “questionable research practices” (QRPs). Where FFP is seen as in
This presentation seeks to specify key features of the civic response to the unprecedented numbers of refugees who arrived in Sweden during the autumn of 2015, and how civic engagement was mobilized. The discussion underscores the theme of moral spectatorship, using Silverstone’s concept of mediapolis, while the analysis highlights the various contingencies that can shape civic engagement. The emp
Piezoelectric transducers were attached in a grid on the surface of an 8 x 2 x 0.08 m concrete floor slab. Through an automated, iterative scheme these were used to transmit and receive 50 kHz, continuous, sinusoidal signals, which were sampled by a multi-channel lock-in amplifier. The measured amplitude and phase were used to locate inflicted damage by detecting deviations from baseline measureme
The simulation toolkit Geant4 was originally developed at CERN for high-energy physics. Over the years it has been established as a swiss army knife not only in particle physics but it has seen an accelerated expansion towards nuclear physics and more recently to medical imaging and y- and ion-therapy to mention but a handful of new applications. The validity of Geant4 is vast and large across man
New elements discovered during past decades have been created in fusion reactions where a lighter nucleus is collided with a heavier one. The new elements created often decay by emitting α particles. From the half-lives of the decays and the energies of the emitted particles one may extract some properties of the new elements. In this talk the recent work performed by the Lund group to model α dec
Coda wave interferometry (CWI) has been demonstrated to be a very sensitive tool for detecting early signs of damage in concrete. The choice of frequency in SHM applications, utilizing coda waves, is not straight-forward, as there is a trade-off in sensitivity and possible propagation distances. This study aims to provide some steps in establishing recommendations as to choice of frequency, when d
