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Several microbial pathogens have been reported to interact with glycosaminoglycans (GAGs) on cell surfaces and in the extracellular matrix. Here we demonstrate that M protein, a major surface-expressed virulence factor of the human bacterial pathogen, Streptococcus pyogenes, mediates binding to various forms of GAGs. Hence, S. pyogenes strains expressing a large number of different types of M prot
Background: Optimal therapeutic management of intravascular lymphoma (IVL) lacks precise guidelines. Patients and methods: The clinico-pathological features of 38 HIV-negative patients with IVL were reviewed to define efficacy of chemotherapy in these malignancies. Clinical characteristics of 22 patients treated with chemotherapy and of 16 untreated patients were compared in order to understand be
This paper takes the treatment of antonymy in Collins COBUILD Advanced Learner's English Dictionary (2003) as the point of departure for a discussion about the principles of antonym inclusion in dictionaries and corpus methodologies in lexicology. CCALED includes canonical antonyms such as good/ bad and dead/alive, as well as more contextually restricted pairings such as hot/ mild and flat/fizzy.
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The complexes formed by the reaction of [Ti(OiPr)(4)] and bicyclo-octanediols (BODOLs) 1 and 2 (1:1) are useful as chiral catalysts in asymmetric reductions and were investigated by H-1 NMR spectroscopy and computational methods. A consistent picture emerged of head-to-tail dimers being kept together via a Ti-O-Ti-O mu-oxo bridge similar to the Ti-tartrates but different from the corresponding Ti-
Long-term treatment with the dopamine precursor levodopa (L-DOPA) induces dyskinesia in Parkinson's disease (PD) patients. We divided hemiparkinsonian rats treated chronically with L-DOPA into two groups: one showed motor improvement without dyskinesia, and the other developed debilitating dyskinesias in response to the treatment. We then compared the plasticity of corticostriatal synapses between
Three approaches for modelling evacuation in the event of fire were studied based on existing computer programs. The programs included in the study were ERM, EVACNET4, STEPS, buildingEXODUS and SIMULEX. However, only some aspects of buildingEXODUS were examined. The three approaches, called network models (ERM and EVACNET4), gridmodels (STEPS and buildingEXOUDUS) and particle models (SIMULEX) diff
We investigate the two-particle spin entanglement in magnetic nanoclusters described by the periodic Anderson model. An entanglement phase diagram is obtained, providing an important perspective on a central property of magnetic nanoclusters, namely, the temperature-dependent competition between local Kondo screening and nonlocal Ruderman-Kittel-Kasuya-Yoshida spin ordering. We find that multipart
A measurement of inclusive jet cross-sections in deep-inelastic ep scattering at HERA is presented based on data with an integrated luminosity of 21.1 pb(-1). The measurement is performed for photon virtualities Q(2) between 5 and 100 GeV2, differentially in Q(2), in the jet transverse energy E-T, in E-T(2)/Q(2) and in the pseudorapidity eta(lab). With the renormalization scale mu(R) = E-T, pertur
An exhaustive and simple method for dispersion flattening in double-clad single-mode fibers is presented. The idea is to generate all such fibers with a certain cutoff wavelength and then find, by one-dimensional minimization and direct inspection, fibers yielding minimum dispersion. As examples, the root mean square chromatic dispersion over the wavelength range (1.25, 1.60 mum) is minimized for
Orientation cage experiments were performed on Capri in Italy, with a diurnal passerine migrant (Tree Pipit Anthus trivialis), and a nocturnal passerine migrant (Garden Warbler Sylvia borin), to study the use of magnetic compass information during autumn passage migration. The experiments were performed outdoors at sunset in: (1) the local geomagnetic field under natural clear skies, (2) a shifted
The LINC transmitter is an architecture that provides linear amplification using nonlinear but power efficient amplifiers. One crucial signal processing function of LINC is the signal component separator (SCS) which forms two constant-amplitude phase-modulated signals from the source signal. This paper presents an analog SCS chip implemented in a 0.35 mum CMOS process using a novel design based on
Backgrounds and Objectives Fresh frozen human plasma is an important raw material in the production of coagulation factor concentrates used in patients with haemorrhagic disorders. The aim of the study was to determine how the handling of plasma influences the recovery of coagulation factor VIII activity (FVIII:C), i.e. the influence of time between donation and freezing, of the freezing time and
In this study, the effects of cation-binding agents used alone and/or in combination with enzymes on solubilisation of municipal sludge and structure changes were investigated. Formic acid, citric acid, tartaric acid, EDTA, sodium tripolyphosphate (STPP), Zeolite A, sodium fluoride, sodium thiosulphate or sodium silicate were added to both biological and digested sludges. Citric acid ( 50 mmol/l)
In an investigation by the Swedish Cancer Society, the present status, critical issues and future aspects and potentials were described by an expert group for each of nine major areas of radiation therapy research. The present report deals with the potential of proton and light ion beams in radiotherapy.
