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As the population of the world increases, there will be a larger number of people with major neurocognitive disorder and anemerging need for prompt diagnosis and treatment. A digital cognitive test could lead to that more people can be tested withoutburdening healthcare. To explore elderly’s experiences of using a digital cognitive test a cognitive healthy population of 70-year-oldswere recruited

Background: During the initial phase of the COVID-19 pandemic, reductions in air pollution were globally observed owing to decreased human activities, underscoring the potential for cleaner air through shifts in human behaviour. Objectives: The objective of the present study was to hypothetically estimate the resulting population health impacts in Malmö, Sweden, if these improvements in air qualit

This paper presents a novel optimization strategy for fitting the Jiles-Atherton (JA) hysteresis model to experimental stator yoke core loss measurements and locked-rotor IPMSM calculations. The first study aims to identify a single set of JA model parameters that track sample core losses at different magnetization levels at a given frequency: the analytical model is compared with finite element m

The FragMAX facility at MAX IV Laboratory is a state-of-the-art platform for crystallographic fragment screening, designed to support structure-based drug and chemical tool compound discovery. This facility offers a comprehensive workflow, from high-throughput crystal preparation and automated diffraction data collection at the BioMAX beamline to advanced data processing and analysis using custom

Executive functions (EF) decline with age and this decline in older adults with generalised anxiety disorder (GAD) may be influenced by heart rate variability (HRV), brain-derived neurotrophic factor (BDNF), and physical fitness. Understanding these relationships is important for tailored treatments in this population. In this study, 51 adults with GAD (M age = 66.46, SD = 4.08) and 51 healthy con

The aim of this study is to assess the content of heavy metals and their potential health risk in consumed food crops. To this end, the samples from vegetables, rice, potato, onion, and black tea were derived from high sales and commonly consumed types. The noncarcinogenic health risk of heavy metals to the adults, teens, and children was estimated by target hazard quotients (THQs) and hazard inde

Tunnel field-effect transistors (TFETs) are a potential alternative to MOSFETs for low-temperature electronics. We provide an in-depth experimental characterization of TFETs analyzing the fundamental physical behavior at different temperature regimes. TFET characteristics from 13 to 300 K both in forward and reverse bias are discussed by employing a variation in InAs/InGaAsSb/GaSb heterojunction v

If AI is to emulate the language, mind, and work of humans, what remains of being human? One scenario is that humans are at risk of becoming robots of AI-powered systems, serving the interests of a few global corporations. We have already reached this stage of transformation. Given this predicament, the issues concerning the capacity of AI beyond the human should be addressed through a critique of

The self-assembly of amyloid-β peptide (Aβ) into fibrils and oligomers is linked to Alzheimer's disease (AD). Fibrillar aggregates in AD patient's brains contain several post-translational modifications, including phosphorylation at positions 8 and 26. These play a key role in modifying the aggregation propensity of Aβ, yet how they affect the mechanism of aggregation is only poorly understood. He

Background: The impact of nonneutralizing antibodies (NNAs) in moderate hemophilia is elusive. Objectives: To explore the presence of NNAs in Nordic persons with moderate hemophilia A (MHA) and B (MHB) in relation to treatment modality, clinical outcome, history of inhibitor, and the corresponding factor VIII (FVIII)/factor IX (FIX) gene mutation. Methods: A cross-sectional multicenter study cover

Maskless UV photolithography is increasingly used, especially in research environments where low turn-around time for new designs improves productivity. Here, we fabricate pyrolytic carbon interdigitated microelectrodes with small interelectrode gaps, good adhesion to the carrier substrate, high surface area and excellent electrochemical properties using maskless UV photolithography with two negat

Background: Despite a good prognosis, survivors of differentiated thyroid cancer (DTC) may have reduced health-related quality of life (HRQOL) many years after treatment, and it is unclear how suppression of thyroid-stimulating hormone (TSH) may contribute to HRQOL. This study investigated changes in HRQOL in the 5 years following DTC treatment, the association between HRQOL and TSH suppression, a

Background Medication abortion, with a combination of mifepristone and misoprostol, is highly effective and safe. However, there is insufficient evidence on efficacy and safety at very early gestations before a pregnancy can be visualized with ultrasonography. Methods We conducted a multicenter, noninferiority, randomized, controlled trial involving women requesting medication abortion at up to 42

A healthy and functional peritoneal membrane is key to achieving sufficient ultrafiltration and restoring fluid balance, a major component of high-quality prescription in patients treated with peritoneal dialysis (PD). Variability in membrane function at the start of PD or changes over time on treatment influence dialysis prescription and outcomes, and dysfunction of the peritoneal membrane contri

Bees are essential pollinators of many crops and wild plants, and pesticide exposure is one of the key environmental stressors affecting their health in anthropogenically modified landscapes. Until recently, almost all information on routes and impacts of pesticide exposure came from honey bees, at least partially because they were the only model species required for environmental risk assessments

Background: Small bowel neuroendocrine tumours often present with locally advanced or metastatic disease. The aim of this paper is to provide evidence-based recommendations regarding (controversial) topics in the surgical management of advanced small bowel neuroendocrine tumours. Methods: A working group of experts was formed by the European Society of Endocrine Surgeons. The group addressed 11 cl

During adolescence, emotion regulation and reactivity are still developing and are in many ways qualitatively different from adulthood. However, the neurobiological processes underpinning these differences remain poorly understood, including the role of maturing neurotransmitter systems. We combined magnetic resonance spectroscopy in the dorsal anterior cingulate cortex (dACC) and self-reported em