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Huntington’s disease is a progressive, untreatable neurodegenerative disorder caused by a mutation in the Huntingtin gene. Next to neurodegeneration, altered immune activation is involved in disease progression. Since central nervous system inflammation and dysfunction of immune cells are recognized as driving characteristics, immunomodulation might represent an additional therapeutic strategy. Sh
This article examines the formation of teenage students as workers through their participation in low-status service jobs, building on Weeks’ theorization of the contemporary work ethic. Based on 40 interviews with working teenagers in Sweden, the analysis explores how they use narratives of working to ‘gain experience’ and ‘earn extra money’ in response to the cultural imperative of constructing
Hundreds of active learning assignments are reported in the political education literature. However, the adaptability of these assignments to new courses can be limited by different learning outcomes, course themes, or institutional contexts. To assist educators in developing assignments that align with their teaching needs, this study introduces the concept of element design. Element design refer
Cluster superlattice membranes constitute a novel 2D material, comprising a cluster superlattice sandwiched between a graphene support and an amorphous carbon embedding matrix. They offer a platform for investigating phenomena at the few atom to small cluster level with lateral averaging techniques. The amorphous carbon matrix provides mechanical and thermal stability to the cluster array, but alt
Importance: Identifying anatomy causally involved in psychosis could inform therapeutic neuromodulation targets for schizophrenia. Objective: To assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit. Design, Setting, and Participants: This case-control study mapped functional connections of published cases of lesions causing secondary psychosis
Purpose Children living with respiratory support rely on medical technology, either fully or partially, throughout the day to meet their breathing requirements. Although children and young people living with respiratory support at home undergo long-term treatments and make extensive use of health and social care services, there is a notable absence of comprehensive outcome data on this group. The
Evolutionary changes in populations of microbes, such as microalgae, cannot be traced using conventional metabarcoding loci as they lack intraspecific resolution. Consequently, selection and competition processes among strains of the same species cannot be resolved without elaborate isolation, culturing, and genotyping efforts. Bamboozle, a new bioinformatic tool introduced here, scans the entire
Över 80 000 personer bor på särskilt boende i Sverige. Flytten dit är ofta livets sista och kan medföra psykisk och fysisk påfrestning med risk för depression, försämrad hälsa och för tidig död. Endast personer med omfattande hjälpbehov beviljas plats, och enligt lag får flytten inte ske mot den äldres vilja. Trots ökad skörhet förväntas individen alltså själv ta stort ansvar för flyttprocessen. DMore than 80,000 people live in nursing homes in Sweden. The move isoften the final relocation in life and may involve both psychological andphysical strain, with risks of depression, deteriorating health, and prematuredeath. Only individuals with extensive care needs are granted placement,and by law, the move cannot be made against the will of the older person.Despite increased frailty, individua
Perovskite electrocatalysts like strontium cobaltite (SrCoOx, denoted as SCO) experience dynamic changes in both surface and bulk during the oxygen evolution reaction (OER), rather than remaining static. This dynamic, electrochemically driven evolution in composition, structure, and ionic defects (e.g., oxygen vacancies) can strongly impact the OER activity and stability. Yet, the current lack of
Nuclear star clusters (NSCs) are among the densest stellar systems in the Universe and are found at the centres of many spiral and elliptical galaxies, and up to 40 percent of dwarf galaxies. However, their formation mechanisms, and possible links to globular clusters (GCs), remain debated. This paper uses cosmological simulations of dwarf galaxies at a spatial resolution of pc to present a new fo
With increasing urbanisation, cities face unique sustainability challenges and opportunities. The sharing economy emerges as a promising solution that can foster more efficient and circular use of urban resources through car sharing, accommodation rentals and the sharing of physical goods. It scrutinises traditional notions of consumption and ownership, business and community interaction. Digital
In recent years, considerable advancements have been made in developing in vitro models to better understand the complex dynamics of the blood-brain barrier (BBB) and its critical role in neurological health and disease. Incorporating astrocytes into these models introduces an essential layer of complexity, allowing for a more comprehensive investigation of the cellular interactions and regulatory
Could maintainability requirements help organizations prioritize technical debt management? The new standard ISO/IEC 5055 Automated Source Code Quality Measures can be used to set targets. We also look at a pragmatic way to turn CodeScene’s code health metric into a quality gate for pull requests.
In this technical note, we introduce a novel approach to studying consensus of continuous-time nonlinear systems with varying topology based on Hilbert metric. We demonstrate that this metric offers significant flexibility in analyzing consensus properties, while effectively handling nonlinearities and time dependencies. Notably, our approach relaxes key technical assumptions from some standard re
As a general-purpose technology, large language models promise to enhance various software engineering tasks. But how will they impact requirements engineering? This column offers a summary of an expert panel discussion from the 2023 International Requirements Engineering Conference in Hanover, Germany.
A novel supramolecular dyad, composed of the electron-accepting N,N’-di(2-(trimethylammoniumiodide) ethylene) perylenediimide (TAIPDI) and the electron donating electron-donating poly[2,5-bis(3-sulfonatopropoxy)-1,4-phenylenealt-1,4-phenylene] sodium salt (PPPOPSO3), was constructed through ionic and electrostatic interactions. Photophysical studies, including steady-state absorption and fluoresce
This column celebrates 40 years of IEEE Software through a retrospective on Requirements Engineering. Two seasoned experts discuss the discipline’s evolution from structured methodologies to AI-driven approaches. Finally, we speculate on future trends.
The chapter examines the environmental impacts of car sharing (CS) by synthesising insights from literature, fieldwork and empirical research. While most studies highlight direct effects such as reduced greenhouse gas emissions and decreased private car ownership, this chapter emphasises the importance of exploring indirect environmental implications, including changes in disposable income and con
