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Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can regulate neuronal excitability through interactions with ion channels2. Polyamines have been linked to pain, showing altered levels in human persistent pain states and mo
Unlike glucose, the sub-optimal xylose utilization in recombinant Saccharomyces cerevisiae strains may stem from an unusual signaling response that is not adapted to detecting xylose as a fermentable substrate. We hypothesize that the membrane receptor Snf3p, known for sensing extracellular low glucose levels, may contribute to xylose recognition. To test this, we explored the effect of SNF3 inact
Vocabularies of space define the world. Yet, despite their apparent conceptual authority (Harley 1989), the lineagesof cartographic entities are often blurred, accidental, and produced from etymologies only imperfectly understoodby their users. Drawing on a recent study on past and present meanings of the term ‘Mesopotamia’ (Rattenborg2018), this paper reviews the inadvertent, if now firmly embedd
Historical sources written in rare or undeciphered scripts represent an immense but underexploited part of the world’s cultural and linguistic heritage. Their study is often hindered by fragmentary preservation, non-standard symbol systems, and the absence of interoperable digital resources. While recent advances in imaging, transcription, and computational analysis have improved access to histori
Background: Autoantibodies against β-cell components in the pancreatic islets of Langerhans are characteristic of type 1 diabetes (T1D). The genetic and autoimmune determinants of type 1 diabetes (T1D) in Ethiopians are not yet thoroughly characterized, with studies indicating a lower occurrence of autoantibodies related to T1D compared to Caucasians. The study aimed to determine the occurrence of
Background: The study aimed to analyze thyroid-stimulating hormone (TSH) levels quantitatively and investigate their potential correlation with the risk of incident atrial fibrillation (AF) in differentiated thyroid cancer (DTC) patients. Methods: DTC cases diagnosed between 1995 and 2015 in Stockholm, Sweden, were identified from the Swedish Cancer Registry. Medical records were scrutinized, and
A major target of the Marxist critique of “post-theory”—a broad term encompassing post-structuralism, post-Marxism, and postcolonial theory—has been its notorious deconstruction of the subject. The affirmation of marginal, excluded, and deviant subject positions within the same corpus has been noted less frequently. To recalibrate the Marxist critique of post-theory to also encompass its affirmati
Loess-palaeosol sequences (LPS) are among the most continuous terrestrial archives of Quaternary climate change. Their widespread distribution, high accumulation potential, and sensitivity to environmental variability make them critical for reconstructing past dust fluxes, wind regimes, and regional ecosystem responses. However, the reliability of such reconstructions is fundamentally constrained
Dupljaja loess-palaeosol sequence in southeasternmost sector of the Banat Loess Plateau (Serbia), situated in the southeastern Carpathian (Middle Danube) Basin, is important for understanding the evolution of the Last Glacial climate and southeastern Carpathian as a potential corridor for human migration throughout Europe. The Dupljaja loess-palaeosol sequence in the southeasternmost sector of the
People often feel less empathy towards outgroup compared to ingroup targets. Overcoming this intergroup empathy bias is important for fostering positive intergroup relations. In five pre-registered and high-powered online studies (n = 4776 (745/745/1056/1236/994)), we attempted to replicate and generalize motivated empathy interventions that previously have made people more empathetic and prosociaPeople often feel less empathy towards outgroup compared to ingroup targets. Overcoming this intergroup empathy bias is important for fostering positive intergroup relations. In five pre-registered and high-powered online studies (n = 4776 (745/745/1056/1236/994)), we attempted to replicate and generalize motivated empathy interventions that previously have made people more empathetic and prosocia
In this study, we investigated overbank sediments of the first terrace of Sava river in Šabac, exposed at a residential building construction site. Sediment characteristics such as grain size, magnetic susceptibility, chemical composition, and loss on ignition (LOI) at 550 °C and 950 °C were determined at 5 cm resolution, accompanied by visual inspection to assess color, pedogenic structure, and o
Triple-negative breast cancer (TNBC) accounts for 10-20% of primary breast cancers and often has early relapses and aggressive progression. An activated tumour immune response can be prognostic in treatment-naive and chemotherapy-treated TNBC patients and may be assessed using gene expression data. We derived a stand-alone predictor for a proposed immunomodulatory transcriptional TNBC subtype in a
Biomarkers for evaluating response to neoadjuvant chemotherapy (NACT) in ER+/HER2- breast cancer remain limited. This study explores the impact of NACT on tumor proliferation dynamics and its association with relapse-free interval (RFI) among 175 patients with early ER+/HER2- breast tumors. Proliferation was assessed at baseline, after completing two NACT cycles, and in the residual tumor using Ki
This article uses empirical investigation of regional hydrogen investments and strategies in Northern Europe to develop a new conceptual approach to regional industrial path development which foregrounds politics and power as explanatory factors in understanding the logics, processes and outcomes of path development. This conceptualisation departs from Evolutionary Economic Geography approaches to
Introduction: Two large multicentre European hospital networks have estimated vaccine effectiveness (VE) against COVID-19 since 2021. Aim: We aimed to measure VE against PCR-confirmed SARS-CoV-2 in hospitalised severe acute respiratory illness (SARI) patients≥20 years, combining data from these networks during Alpha (March–June)- and Delta (June–December)dominant periods, 2021. Methods: Forty-six
Stingless bees (Meliponini) are important pollinators in tropical ecosystems and very abundant in the Bolivian Yungas region; yet little is known about their foraging behavior and floral preferences. In this study, we combined melissopalynology, pollen analysis from honey, with plant-pollinator interactions network to investigate foraging behavior and niche overlap of three rescued stingless bee s
