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Aims P2Y(12) receptor antagonism and platelet inhibition by prasugrel vs. clopidogrel were investigated in patients with stable coronary artery disease. Methods and results One hundred and ten aspirin treated subjects were randomized to double-blind treatment with clopidogrel (n = 55) 600 mg loading dose (LD) and 75 mg maintenance dose (MD) or prasugrel (n = 55) 60 mg LD and 10 mg MD for 28 days.
In this paper, we consider robust stability analysis of large-scale sparsely interconnected uncertain systems. By modeling the interconnections among the subsystems with integral quadratic constraints, we show that robust stability analysis of such systems can be performed by solving a set of sparse linear matrix inequalities. We also show that a sparse formulation of the analysis problem is equiv
Background: Antimicrobial peptides (AMPs) are receiving increasing attention due to resistance development against conventional antibiotics. Pseudomonas aeruginosa and Staphylococcus aureus are two major pathogens involved in an array of infections such as ocular infections, cystic fibrosis, wound and post-surgery infections, and sepsis. The goal of the study was to design novel AMPs against these
Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status. To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease. In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45-64 years on a strict gluten-free diet for several years were ra
One of the key research and policy problems in innovation studies is the development of tools for understanding and measuring the impact of academic research on society. The paper contributes to resolving this problem by providing a typology that helps us to understand and analyse the roles researchers take on in order to make academic knowledge useful. A key finding is that utility creation is co
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglyceri
Introduction: Life-history theory predicts that organisms trade off survival against reproduction. However, the time scales on which various consequences become evident and the physiology mediating the cost of reproduction remain poorly understood. Yet, explaining not only which mechanisms mediate this trade-off, but also how fast or slow the mechanisms act, is crucial for an improved understandin
Aims The recurrence of foot ulcers is a significant problem in people with diabetic neuropathy. The purpose of this study was to measure in-shoe plantar pressures and other characteristics in a group of neuropathic patients with diabetes who had prior foot ulcers which had remained healed. Methods This was an epidemiological cohort study of patients from diabetes clinics of two Swedish hospitals.
In this paper I discuss doubling with the neuter pronominal det ‘it’ in Swedish. Det may double common gender and/or plural noun phrases too, which gives rise to what looks like disagreement. The proposed analysis takes as its point of departure so-called pancake-sentences, which are sentences with a common gender and/or plural noun phrase subject, but where the predicative adjective agrees in the
Although octupoles, decapoles, and longitudinal gradient bending magnets (LGB) have been studied for many years, they are not usually included in light source lattices. They can, however, be beneficial in order to realize ultralow emittance and attain sufficient dynamic aperture. We present methods for achieving ultralow emittance and discuss optimization of the nonlinear dynamics with multipoles.
Abstract in French Cet article décrit certains des dénominateurs communs de la fiction criminelle nordique : des caractéristiques allant au-delà du cadre géographique, qui sont partagées par une majorité de la fiction incluse dans des concepts tels que Nordic Noir ou Scandicrime, et qui semblent rendre cette fiction particulièrement attrayante vis-à-vis des lecteurs internationaux. Cinq de ces facThis article outlines some of the common denominators of Nordic crime fiction: characteristics beyond the geographical setting, which are shared by a majority of the fiction included in concepts like Nordic Noir or Scandicrime, and which seem to make this fiction especially attractive to international readers. Five such factors are found to be of particular importance: 1) The Stieg Larsson effect,
1 alpha,25-Dihydroxyvitamin D-3 (1 alpha,25(OH)(2)D-3) had earlier been regarded as the only active hormone. The newly identified actions of 25-hydroxyvitamin D-3 (25(OH)D-3) and 24R,25-dihydroxyvitamin D-3 (24R,25(OH)(2)D-3) broadened the vitamin D-3 endocrine system, however, the current data are fragmented and a systematic understanding is lacking. Here we performed the first systematic study o
A detector with high dynamic range designed for combined small-and wide-angle x-ray scattering experiments has been developed. It allows measurements on single events and reactive systems, such as particle formation in flames and evaporation of levitating drops. The detector consists of 26 channels covering a region from 0.5 degrees to 60 degrees and it provides continuous monitoring of the sample
The salinity problem is becoming increasingly widespread in arid countries. In semiarid Tunisia about 50% of the irrigated land is considered as highly sensitive to salinization. To avoid the risk of salinization, it is important to control the soil salinity and keep it below plant salinity tolerance thresholds. The objective of the present study was to provide farmers and rural development office
We report the growth and characterization of GaSb nanowires grown by MOVPE. The structural properties of the nanowires are investigated by the means of transmission electron microscopy, X-ray diffraction and single nanowire photoluminescence. The measurements confirm a high material quality in the GaSb nanowires. Also, a back-gated nanowire transistor structure is used to extract values for the po
The 2s and 2p photoelectron spectra have been measured for Na(+), Mg(2+), and Al(3+) ions in aqueous solution. In all cases, the 2s lines are significantly broader than the 2p features, which is attributed to a shorter lifetime of the respective 2s hole. Since intraionic Coster-Kronig decay channels from the (2s)(-1) state are closed for free Na(+), Mg(2+), and Al(3+) ions, this is evidence for an
Background: Hybridization and polyploidy are potent forces that have regularly stimulated plant evolution and adaptation. Dactylorhiza majalis s.s., D. traunsteineri s.l. and D. ebudensis are three allopolyploid species of a polyploid complex formed through unidirectional (and, in the first two cases, recurrent) hybridization between the widespread diploids D. fuchsii and D. incarnata. Differing c
