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INTRODUCTION: In recent years, the field of graft preservation has made considerable strides in improving outcomes related to solid organ restoration and regeneration. Ex vivo lung perfusion (EVLP) in line with the related devices and treatments has yielded promising results within preclinical and clinical studies, with the potential to improve graft quality. Its main benefit is to render marginal
The deregulation of BCL2 family proteins plays a crucial role in leukemia development. Therefore, pharmacological inhibition of this family of proteins is becoming a prevalent treatment method. However, due to the emergence of primary and acquired resistance, efficacy is compromised in clinical or preclinical settings. We developed a drug sensitivity prediction model utilizing a deep tabular learn
This paper explores the link between the metaphoric structure TIME IS SPACE and time perception in bilinguals. While there appear to be fundamental commonalities in the way humans perceive and experience time regardless of language background, language-specific spatiotemporal metaphors can give rise to differences between populations, under certain conditions. Little is known, however, about how b
This article studies the consequences of adult income resulting from exposure to poverty at the neighbourhood and family levels for children aged 1-17 in Southern Sweden from 1947 to 1967. We used geocoded information at the address level to identify k-neighbourhoods of various sizes and applied both relative and absolute poverty measurements, all yielding similar results. Moreover, our longitudin
We investigated bidirectional cross-linguistic influence on motion event (ME) expressions in bilingual speakers of two typological different languages (Talmy’s typology), Spanish (as L1) and English (as L2). Specifically, we investigated whether bilingual speakers struggle to learn ME expressions in the L2, and whether this process affects ME uses in the L1. Potential effects of L2 proficiency and
Did the political COVID-19 pandemic impact levels of populism? And did a potential effect travel across different national pandemic strategies? Populism is characterized by a growing antagonistic elite-population gap, which might be further triggered by top-down pandemic legislation. Using large-n panel survey data from Denmark and Sweden, being two similar Scandinavian universal welfare states th
It is well known that antipsychotic drugs (APDs) are more effective in reducing symptoms in women than in men, and that women are more sensitive to the side effects of APDs. Therefore, it is of great importance that sex differences in drug responses are considered already in the early stages of drug development. In this study, we investigated whether sex-specific differences could be observed in r
Background: Risk of fragility fractures in patients with rheumatoid arthritis (RA) is increased. Disease-related inflammation in RA is associated with low Bone Mineral Density (BMD). However, effects of specific disease factors on fracture occurrence and whether or not such disease effects are independent of BMD are unknown. Methods: Analysis of fracture outcome in the prospective cohort of 2557 p
A sports-related concussion (SRC) is often caused by rapid head rotation at impact, leading to shearing and stretching of axons in the white matter and initiation of secondary inflammatory processes that may exacerbate the initial injury. We hypothesized that athletes with persistent post-concussive symptoms (PPCS) display signs of ongoing neuroinflammation, as reflected by altered profiles of cer
Electric vehicles may represent a new type of risk and require a change in fire protection and firefighting techniques in vehicle carriers and parking garages. This study presents an experimental assessment of firefighting techniques and fire dynamics of electric cars in an open-sided enclosure. The enclosure had dimensions of 12.2 m by 7.1 m, and openings of 7.1 m by 2.4 m on either end of the en
OBJECTIVE: To investigate potential risk factors behind the increased incidence of necrotising enterocolitis (NEC) in Swedish extremely preterm infants.DESIGN: Registry data from two population-based national cohorts were studied. NEC diagnoses (Bell stage ≥II) were validated against hospital records.PATIENTS: All liveborn infants <27 weeks of gestation 2004-2007 (n=704) and 2014-2016 (n=895) in S
BACKGROUND: We investigated ophthalmological outcomes at 2.5 years of corrected age in children born extremely preterm (EPT) to evaluate the effects of postnatal enteral supplementation with ω-3 and ω-6 long-chain polyunsaturated fatty acids.METHODS: In the Mega Donna Mega clinical trial, EPT infants born at less than 28 weeks of gestation were randomized to receive an enteral supplementation of d
Neonates with critical congenital heart defects undergoing open-heart surgery on cardiopulmonary bypass circulation are at risk for white matter brain injury. This article reports on pre- and postoperative plasma concentrations of brain injury markers glial fibrillary acidic protein (GFAP), neurofilament light (NfL) and Tau, and their respective associations with white matter lesions detected on p
Left ventricular shape alterations predict cardiovascular outcomes and have been observed in children born preterm and after fetal growth restriction (FGR). The aim was to investigate whether left ventricular shape is altered in adolescents born very preterm and if FGR has an additive effect. Adolescents born very preterm due to verified early-onset FGR and two control groups with birthweight appr
OBJECTIVE: To quantify the risks of mortality, morbidity and postnatal characteristics associated with extreme preterm fetal growth restriction (EP-FGR).DESIGN: The EVERREST (Do e s v ascular endothelial growth factor gene therapy saf e ly imp r ove outcome in seve r e e arly-onset fetal growth re st riction?) prospective multicentre study of women diagnosed with EP-FGR (singleton, estimated fetal
OBJECTIVE: To compare the effect of intervention at low vs high threshold of ventriculomegaly in preterm infants with posthemorrhagic ventricular dilatation on death or severe neurodevelopmental disability.STUDY DESIGN: This multicenter randomized controlled trial reviewed lumbar punctures initiated after either a low threshold (ventricular index of >p97 and anterior horn width of >6 mm) or high t
OBJECTIVE: To compare the effect of early and late intervention for posthemorrhagic ventricular dilatation on additional brain injury and ventricular volume using term-equivalent age-MRI.STUDY DESIGN: In the Early vs Late Ventricular Intervention Study (ELVIS) trial, 126 preterm infants ≤34 weeks of gestation with posthemorrhagic ventricular dilatation were randomized to low-threshold (ventricular
The food industry generates side streams that can be used as sources of valuable compounds. We carried out a life cycle assessment of a protein ingredient obtained by pH-shift processing co-products of herring (Clupea harengus) and lingonberry (Vaccinium vitis-idaea) pomace. The assessment was based on a combination of primary and literature data to assess climate change, cumulative energy demand,
