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The aggregation of tau into amyloid fibrils is associated with Alzheimer’s disease (AD) and related tauopathies. Since different tauopathies are characterized by the formation of distinct tau fibril morphologies, it is important to combine the search of tau aggregation inhibitors with the development of in vitro tau aggregation assays that recapitulate aggregation as it may occur in the brain. Her
High-resolution transmission spectroscopy has become a powerful tool for detecting atomic and ionic species in the atmospheres of ultra-hot Jupiters. In this study, we demonstrate for the first time that the Australian-built Veloce spectrograph on the 3.9-m Anglo-Australian Telescope can resolve atmospheric signatures from transiting exoplanets. We observed a single transit of the ultra-hot Jupite
The presence of lipids after pea protein isolation was related to changes in protein structure and functionality. The aim of this study is to investigate the effects of the presence of lipids, specifically polar endogenous lipids (phospholipids), on pea globulins' (including legumin and vicilin) structure and functionality. Pea globulins were extracted by isoelectric precipitation from defatted an
Therapeutic proteins are essential in modern medicine but are often susceptible to chemical degradation during production, transportation, and storage, which can compromise functionality and even lead to immunogenicity in patients. This study investigates how the structure of the affibody GA-Z affects its chemical stability and how glycerol stabilizes the protein against deamidation and isomerizat
Svenska myndigheter ska enligt vår svenska grundlag vara fristående från regeringen. Är detta fristående tillräckligt för de krav på oberoende som EU-rätten ställer? Den frågan undersöks i detta avsnitt av Sieps Podcast.
Single-nucleus RNA sequencing enables high-resolution transcriptomic profiling of brain tissue, facilitating analysis of cell identity in models of neurodegeneration and repair. Here, we present a protocol for isolating nuclei from long-term human stem cell-derived grafts in the rat brain. We describe steps for vibratome sectioning, graft dissection, nuclear extraction, and fluorescence-activated
Multi-hazard events, though infrequent and rare, are responsible for a substantial portion of global economic losses. This book chapter investigates the complexities of multi-hazard events and explores the design challenges and methodologies in multi-hazard risk assessment and structural resilience for wooden structures. Special attention is given to the interaction between earthquakes, fires, and
Climate limits distribution of species and shows considerable regional variability. However, studies relating climate variation to species population growth rates in different climatic zones while accounting for species' ecological traits are scarce. We assessed species population responses to the main climatic constraints at a continental scale by studying how precipitation and temperature at dif
Fire safety and fire protection objectives require that buildings and parts of buildings do not collapse during a fire. This requires that the load-carrying capacity is maintained to a minimum acceptable level during a fire. This chapter briefly describes the historical background and state of the art of fire resistance and its determination for timber members through testing or calculations. The
När två oväntade silverspiror dyker upp i Kulturens magasin startar en historisk detektivresa för arkivarien Henrik Ullstad. Jakten på svar leder långt tillbaka i universitetets ceremoniella traditioner – och fram till upptäckter som utmanar den gängse bilden av dessa ikoniska föremål.
This study investigates the surface transformations of nickel foam (NF) electrodes induced by Fe and Co cation incorporation from the electrolyte following activation in the oxygen evolution reaction (OER), using both ex situ time-of-flight secondary ion mass spectrometry (TOF-SIMS) and in situ near-ambient pressure X-ray photoelectron spectroscopy (NAP-XPS). Electrochemical measurements demonstra
Philanthropy for gender causes is recognised as a rising yet understudied phenomenon, especially in the field of social policy. This chapter provides an overview of key interdisciplinary feminist debates on the philanthropic turn to gender equality and women's empowerment. It also presents significant trends, including funding flows towards SDG5, key actors, and geographical areas of investment, a
This special issue deals with temporalities in migration law with particular emphasis on the European context. At the crossroads of several legal fields, including public law, human rights law, EU law and public international law, the topic is cutting-edge in migration law. The articles collected were originally presented at a conference organized at Vrije Universiteit in Amsterdam in June 2023 an
It is well known that in interdisciplinary consciousness studies there are various competing hypotheses about the neural correlate(s) of consciousness (NCCs). Much contemporary work is dedicated to determining which of these hypotheses is right (or the weaker claim is to be preferred). The prevalent working assumption is that one of the competing hypotheses is correct, and the remaining hypotheses
Policymaking around educational technology (ed-tech) is increasingly influenced by networks of public and private actors ranging from Big Tech corporations and international organisations through to ed-tech evidence brokers and consultants. This paper considers a relatively unexplored facet of contemporary ed-tech policy work – public-facing (ex)teachers advocating for technological change through
Extremely preterm infants are at risk of immune-mediated complications such as infections and inflammatory conditions like bronchopulmonary dysplasia and necrotizing enterocolitis. Preterm infants are immunologically distinct from term infants at birth, but subsequently undergo adaptive postnatal changes resulting in immunological convergence during their first 3 months. Here, we performed a syste
Physical activity lowers risk of cardiovascular disease and may also decrease arterial stiffness. We aimed to investigate whether arterial stiffness can explain part of the association between physical activity and the risk of major adverse cardiovascular events (MACE) and all-cause death in men and women. We followed 2583 individuals from the Malmö Diet and Cancer study (2007-2012) for occurrence
In this study, a serial production system consisting of two machines and an intermediate finite buffer is considered. The machines have random processing times, and each machine contains one unit of a common critical component that is subject to random breakdown. Broken components must be replaced from an inventory of ready-for-use spare parts to restore machine functionality. This inventory is re
BACKGROUND: Totally implantable venous access ports (TIVAPs) are essential for administering chemotherapeutic drugs and nutritional support, but carry a risk of infectious complications. We hypothesized that the design of the current port needle (Huber) could facilitate the collection of bacteria from the skin during puncture, potentially introducing them into TIVAPs and causing infections. This s
