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Objective To assess patient's self-reported global assessment of health (PGA) in relation to inflammation, pain and disability in patients with rheumatoid arthritis (RA). Methods Data were obtained from the Better Anti-Rheumatic PharmacOTherapy early RA cohort, in which patients were scheduled for follow-up of 15 years. Longitudinal PGA trajectories were identified using hierarchical agglomerative

The precuneus is a site of early amyloid-beta (Aβ) accumulation. Previous cross-sectional studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits or elevated Aβ. However, longitudinal studies in early Alzheimer’s disease (AD) are lacking and the relationship to the Apolipoprotein-E (APOE) genotype is unclear. Investigating the PREVENT-AD dataset, we assessed

Reading An Yu’s Poetry (Preface)

The age-specific incidence of traumatic brain injury in older adults is rising in high-income countries, mainly due to an increase in the incidence of falls. The severity of traumatic brain injury in older adults can be underestimated because of a delay in the development of mass effect and symptoms of intracranial haemorrhage. Management and rehabilitation in older adults must consider comorbidit

Background: Prostate cancer therapy with surgical or chemical castration with gonadotropin-releasing hormone (GnRH) agonists has been linked to elevated follicle-stimulating hormone (FSH) levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unc

Acute leukemia affects individuals of all ages and encompasses a heterogeneous group of malignancies driven by genetic alterations that give rise to leukemia stem cells (LSCs), which sustain self-renewal and drive the expansion of abnormal cells. Based on how these alterations affect maturation, acute leukemia is classified into acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Acute leukemia affects individuals of all ages and encompasses a heterogeneous group of malignancies driven by genetic alterations that give rise to leukemia stem cells (LSCs), which sustain self-renewal and drive the expansion of abnormal cells. Based on how these alterations affect maturation, acute leukemia is classified into acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Aim: The aim of this study was to explore the role of managers and employees with an assigned responsibility (i.e. inspirers) when integrating recovery-enhancing activities into everyday work in a primary health care setting. Background: The possibility of recovery during the workday is essential for employee wellbeing. However, the literature on workplace interventions focusing on recovery is sca

Objective To compare work loss after starting tumour necrosis factor inhibitors (TNFi), rituximab, abatacept or tocilizumab in patients with rheumatoid arthritis (RA). Methods We used data from the Swedish Rheumatology Quality Register to identify patients aged 19-62 years who were treated with TNFi (n=15 093), rituximab (n=2123), abatacept (n=1877) or tocilizumab (n=1720) between 2007 and 2020. D

Putting her watch on her wrist and the phone in her bag, she was ready to leave for work. The secret she was carrying had to be dealt with later. She had not fully decided yet what to do about it. Maybe she should pay the clinic a visit, just have a chat. What could be the harm in that?Once again, he felt constrained in his work. The system did not really fit. It spilled over into his personal lif

The present study offers a first comprehensive, quantifiable overview of the geographical extent and scale of the cuneiform corpus. Though one of the oldest and longest-lived scripts in history, the sheer size of this corpus, being among the largest discrete bodies of written source material from the pre-modern world, is seldom properly appreciated. We review and evaluate past quantitative assessm

The catalytic conversion of carbon dioxide (CO2) to methanol over Cu/ZnO catalysts is expected to become valuable for recycling CO2. The nature of the Cu-Zn interplay remains a subject of intense debate due to many different Zn species encountered in Cu/ZnO catalysts. In this study, we designed a Cu-Zn catalyst by ion-exchanging Cu into CIT-6, a crystalline microporous zincosilicate with the BEA*

We present an index providing estimates of the number of cuneiform inscriptions derived from individual archaeological locations, along with bibliographical references for these estimates. Archaeological finds of cuneiform inscriptions are known from across Europe, Asia, and Africa, with the present index including an aggregate 430,000 inscriptions distributed across 600 locations. This index can

Introduction: Out-of-pocket health expenditures (OOPE) are an inefficient and inequitable means of health financing. Identifying the factors driving these expenditures is crucial to design effective prepayment schemes. This study uses Cambodia—a country with high OOPE and prevalent informal employment—as a case study to analyse the relative contributions of healthcare, health, and social factors t

The human gut microbiome is a highly complex environment, where a myriad of intricate microbiota-microbiota and microbiota-host interactions occur. The human gut microbiota has been associated with both health and disease. The research presented in this thesis focuses on investigating how the butyrate-producing human gut bacterium Roseburia hominis A2-183 (R. hominis) processes β-mannan oligosacch