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Background: Despite substantial progress in the field of mass spectrometry, there remain barriers to measuring the extracellular vesicles (EVs) proteome in blood plasma. Recent work has shown that isolating EVs can make it possible to detect proteins that have low abundance in plasma. Commonly used EV isolation methods either require large sample volumes and long ultracentrifugation times, or else
Compound heterozygosity for strong hypomorphic mutations in the PRKN gene is a common cause of autosomal familial Parkinson's disease (PD). We generated an iPSC cell line from the fibroblasts of a PARKIN protein-deficient early-onset PD female patient, carrying genomic deletions of exon 2 and exons 5–7. This line displays characteristic human iPSC morphology and expression of pluripotency-associat
Indonesia faces a severe plastic pollution crisis driven by extensive plastic usage and inadequate waste management. To effectively address this issue and promote sustainable circularity, it is crucial to understand the dynamics of plastic production, use, and end-of-life management, as well as the interactions among stakeholders throughout the plastics lifecycle. Without such a comprehensive unde
The fate of the Fermi surface in bulk electron-doped Sr2IrO4 remains elusive, as does the origin and extension of its pseudogap phase. Here, we use high-resolution angle-resolved photoelectron spectroscopy (ARPES) to investigate the electronic structure of Sr2−xLaxIrO4 up to x = 0.2, a factor of two higher than in previous work. We find that the antinodal pseudogap persists up to the highest dopin
Model-based design is an emerging tool for dealing with the uncertain dynamic loads entering wastewater treatment plants (WWTPs). But our understanding about the load-driving population-dynamics is limited. Therefore, we studied if mobility data (mobile telecommunications data) could be used to reduce uncertainties during design. Mobility data from Uppsala, Sweden between 2019–2022 clearly quantif
Cardiovascular disease (CVD) is the leading cause of death in Europe, with myocardial infarction (MI) being one of its most severe manifestations. While many risk factors for CVD are well known, occupational exposures remain relatively understudied—especially in analyses that adjust for co-occurring workplace exposures. This study aimed to examine the association between occupational exposure to c
Cigarette smoke (CS), a major driver of lung cancer (LC), promotes epithelial-mesenchymal transition (EMT) and stemness resulting in metastasis, therapy resistance, and recurrence, but the precise mechanism is elusive. Building on our earlier identification of Runt related transcription factor-2 (RUNX2) and Galectin-3 (Gal-3) as mediators of CS-induced EMT, in this study, we aimed to identify a po
Background: Neoadjuvant therapy is protective of postoperative pancreatic fistula in pancreatoduodenectomy. However, the effect of neoadjuvant therapy after left pancreatectomy remains unclear. The aim of this international multicenter study was to evaluate the impact of neoadjuvant therapy on short term outcomes after left pancreatectomy for pancreatic ductal adenocarcinoma. Methods: Patients und
We study a class of radially symmetric Coulomb gas ensembles at inverse temperature β=2, for which the droplet consists of a number of concentric annuli, having at least one bounded “gap” G, i.e., a connected component of the complement of the droplet, which disconnects the droplet. Let n be the total number of particles. Among other things, we deduce fine asymptotics as n→∞ for the edge density a
Objective: Mitochondria are involved in cellular metabolism, energy production, calcium homeostasis, and the synthesis of sterols and bile acids (BAs). Emerging evidence suggests that mitochondrial dynamics including biogenesis, fusion, fission, and mitophagy critically influence cardiometabolic diseases, yet their role in atherogenesis remain poorly understood. Mitochondrial fusion ensures metabo
Background: Paleolithic Diet Fraction (PDF) and Paleolithic Diet Score (PDS) are both measures of how closely a food intake conforms to a Paleolithic dietary pattern. PDF is calculated directly from an individual’s absolute food intake and PDS is an aggregated score based on an individual’s food intake relative to a population. Both are inversely associated with all-cause and cause-specific mortal
Abstract in French:L’article part d’une énigme empirique : le cas d’une usine de petite taille dans une ville industrielle ukrainienne semble contredire tout ce qu’on savait sur le paternalisme industriel et les attitudes contestataires des ouvrier·e·s dans ce pays. Contrairement aux grandes entreprises de la même ville, cette usine jouit de la paix sociale sans avoir à la garantir avec le « salaiThis article begins with an empirical puzzle: the case of a small factory in an industrial Ukrainian city appears to contradict everything we thought we knew about industrial paternalism and workers’ contestatory attitudes in the country. Unlike the large companies in the same city, this factory enjoys social peace without having to guarantee it through a “social wage”. How does management succeed
Background/Aim: The TGF-β pathway can influence breast cancer progression and therapy efficacy, exhibiting both pro- and anti-tumoral effects. This study examined the impact of active TGF-β signaling on recurrence and radiotherapy (RT) benefit in early-stage breast cancer, using nuclear phosphorylated Smad2 (pSMAD2) as a marker for pathway activation. Methods: Tissue-microarrays from 1178 stage I-
The article analyses strategies developed by Ukrainians who arrived in France since 2022 and who have to deal with the difficult real estate market trying to find a place to live. Going beyond the structuralist framework, the authors investigate subjective motivations and attitudes that combine with structural factors to produce different strategies of adaptation to the French housing market. Thes
Background: Management of severe aortic stenosis (AS) has evolved over the past decade, driven by the widespread adoption of transcatheter aortic valve implantation (TAVI). This study aims to assess trends in procedural volumes, patient characteristics, and outcomes for patients undergoing TAVI or surgical aortic valve replacement (SAVR) in Sweden. Methods: This was a descriptive, non-comparative,
The 2024 Lund University Conference on Teaching and Learning, hosted by MedCUL and the Division for Higher Education Development (AHU), took place in the newly inaugurated Forum Medicum – an environment purposefully designed to inspire connection, collaboration, and exchange. The venue’s open architecture mirrored the conference theme, Connecting teachers – changing from within, underscoring the r
A major reason for the great interest in regional industrial path development (RIPD) is the associated hopes for positive regional development outcomes. However, up to now we know surprisingly little about the often mixed economic, social and ecological effects of RIPD for regions. Existing studies on RIPD tend not to link to these outcomes. This special collection aims to improve our understandin
The chapter discusses the theoretical reorientation in economic geography over the last twenty years from a focus on structures, represented by regional innovation systems, to addressing the role of human agency in regional economic development, and reflects on what the two approaches can contribute to achieving sustainable regional restructuring. We are doing this by focusing on two articles – pu
The many challenges of our time call for changes in regional economies, increasingly motivating scholars to dive deep into the mechanisms and possibilities for delivering such change. However, the link between regional change and people’s well-being has often been neglected, assuming that new job opportunities, green industrial path development, or higher-value economic activities are inherently g
