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BACKGROUND: Metabolic alterations contribute to disease onset and prognosis of Huntington's disease (HD). Weight loss in the R6/2 mouse model of HD is a consistent feature, with onset in mid-to-late stage of disease.OBJECTIVE: In the present study, we aimed to investigate molecular and functional changes in white adipose tissue (WAT) that occur at weight loss in R6/2 mice. We further elaborated on
This paper presents new estimates of the material livings standards among the rural population in southern Sweden from the 1680’s up to 1865. Utilizing a newly constructed database of circa 1800 probate inventories from the benchmark periods 1680-1720, 1780-85, and 1860-65, we analyse the development of consumption patterns for rural households. Wefind that that all rural households, no matter the
Integration of fiber modification step with a modern pulp mill is a resource efficient way to produce functional fibers. Motivated by the need to integrate polymer adsorption with the current pulping system, anion-specific effects in carboxymethylcellulose (CMC) adsorption have been studied. The QCM-D adsorption experiments revealed that CMC adsorption to the cellulose model surface is prone to an
This paper studies the nexus between income and wealth inequality, and the ecological footprint in the United States and France from 1962 to 2021. Based on theoretical considerations, we allow the relationship to vary over time. We find some support for income inequality affecting the ecological footprint in the United States and that the relationship has changed over time. We find no such result This paper studies the nexus between income and wealth inequality, and the ecological footprint in the United States and France from 1962 to 2021. Based on theoretical considerations, we allow the relationship to vary over time. We find some support for income inequality affecting the ecological footprint in the United States and that the relationship has changed over time. We find no such result
Optimising waste management is one of the key areas in sustainable development to protect public health and the environment. However, most countries are yet to achieve sustainable waste management due to increasing waste generation, limited landfill space, resource depletion, cost of recycling, public buy-in, etc. These challenges have resulted in poor waste management and environmental pollution
The understanding of small cell lung cancer (SCLC) biology has increased dramatically in recent years, but the processes that allow SCLC to progress rapidly remain poorly understood. Here, we advocate the integration of rapid autopsies and preclinical models into SCLC research as a comprehensive strategy with the potential to revolutionize current treatment paradigms.
In this study we use finite rate chemistry Large Eddy Simulation (LES) to examine flow, injection, mixing, self-ignition and turbulent combustion in a dual-mode ramjet combustor with a cavity flameholder. The target case is the dual-mode ramjet combustor studied experimentally by Micka & Driscoll in a series of publications under different operating conditions characterized by varying air stag
In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele associated with each T- and B-cell receptor sequence is a crucial step. This process is highly impacted by allele annotations. Aligning sequences, assigning them to specific germline alleles, and inferring individual genotypes are challenging when the repertoire is highly mutated, or sequence reads do not
This study explores the challenges and possibilities of using ammonia (NH3) as a carbon-free fuel for marine propulsion in a Wärtsilä ammonia/diesel dual-fuel engine using a reactivity-controlled compression ignition (RCCI) concept. The main issues in ammonia RCCI engines are high ammonia slip and high emissions of nitrogen oxides and nitrous oxide. A joint experimental and computational investiga
BACKGROUND: Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA (mtDNA) copies range from 100s to 10,000s per cell, thus providing a potentially alternative to identify potential missing cancer information in circulation at an early stage.METH
Microglia have an innate immunity memory (IIM) with divergent functions in different animal models of neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized by chronic neuroinflammation, neurodegeneration, tau tangles and β-amyloid (Aβ) deposition. Systemic inflammation has been implicated in contributing to the progression of AD. Multiple reports have demonstrated uni
Objective. To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-Associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. Methods. Patients with a definite diagnosis of AAV who were followed for ? 3 months and had sufficient documentation were included. Data o
The self-diffusion coefficients of D2O (i.e., heavy water or 2H2O) in eight n-alkanes at 298 K were investigated using 2H NMR diffusometry. D tended to decrease in the n-alkanes with increasing carbon number and be inversely proportional to the n-alkane viscosity to a fractional power. The hydrodynamic radius of D2O in the n-alkanes, calculated from Stokes-Einstein-Sutherland equation with stick b
Demographic trends and advances in accessibility have led to more heterogeneous populations in public buildings. While providing accessible evacuation, it may be necessary to direct evacuees to different evacuation paths depending on functional capacity. The presence of people with mobility limitations (e.g., wheelchair users) may affect the evacuation of others, possibly influencing the decision
Understanding the public's views and acceptability of shared micromobility (SMM) is crucial for uncovering barriers to incorporating SMM into sustainable urban mobility. This research studies stereotypes of SMM and their impacts on SMM's public acceptability. We focus on shared e-scooters and shared bikes/e-bikes in England, the Netherlands, and Sweden. We conceptualise stereotypes of SMM, develop
This is the first report comparing EULAR and national treatment recommendations for PsA patients across Europe, and the first this decade to compare ASAS-EULAR and national treatment recommendations in axSpA patients. An electronic survey was completed from October 2021–April 2022 by rheumatologists in 15 European countries. One and four countries followed all EULAR and ASAS-EULAR recommendations,
Audio description (AD) serves a critical role in making film narratives accessible to visually impaired audiences, aiming to enhance their viewing experience and comprehension. One method to assess the comprehension of film narratives, is through an event segmentation task, wherein participants delineate the narrative unfolding into distinct meaningful events. In the present study, both sighted anAudio description (AD) serves a critical role in making film narratives accessible to visually impaired audiences, aiming to enhance their viewing experience and comprehension. One method to assess the comprehension of film narratives, is through an event segmentation task, wherein participants delineate the narrative unfolding into distinct meaningful events. In the present study, both sighted an
BACKGROUND: Humans differ in the metabolism of the neurotoxicant methyl mercury (MeHg). This variation may be partially due to variation in genes encoding the transcription factor Nuclear factor E2-related factor 2 (NRF2) and its negative regulator Kelch-like ECH-Associated Protein 1 (KEAP1), which regulate glutathione and related transporter and antioxidant proteins that play a role in the metabo
Inadequate adaption to mechanical forces, including blood pressure, contributes to development of arterial aneurysms. Recent studies have pointed to a mechanoprotective role of YAP and TAZ in vascular smooth muscle cells (SMCs). Here, we identified reduced expression of YAP1 in human aortic aneurysms. Vascular SMC–specific knockouts (KOs) of YAP/TAZ were thus generated using the integrin α8–Cre (I
