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The hippocampus, crucial in cognitive aging and Alzheimer’s disease (AD), shows early atrophy during disease progression. This study investigated 5-year trajectories of hippocampal volumes across AD stages, focusing on genetic predisposition to AD, captured through the polygenic risk score for AD (PRS-AD) and APOE, and their impact on hippocampal atrophy. Analyzing data from 1,051 participants in
Strategic sustainability communication in organizations managed by financial objectives is characterized by paradoxical tensions that arise within the organization when sustainability goals are added. Yet the dominant perspective on sustainability among practitioners and researchers is the Business Case Frame (BCF) which is ill-suited to address these tensions. This chapter is built on a qualitati
Introduction/Objective: Hepatocellular carcinoma (HCC) is a highly heterogeneous malignant tumor, characterized by elevated mortality rates and poor diagnostic outcomes. Accurate identification of cancer subtypes is crucial for guiding personalized treatment and improving patient prognosis. Methods: A method for precisely identifying HCC subtypes by integrating multi-omics data was presented. This
Drawing on a constitutive understanding of strategic communication [Falkheimer and Heide (Strategic communication: An introduction. Routledge, 2018), (Strategic communication: An introduction to theory and global practice. Routledge, 2022); Winkler and Schoeneborn (The research handbook of strategic communication. Edward Elgar, 2023)], this chapter examines how the municipality of Venice’s strateg
Rationale: A care bundle approach to the management of spontaneous intracerebral hemorrhage (ICH) has been shown to benefit patients in low- and middle-income countries (LMIC), but uncertainty persists over the specific components and its applicability in high-income countries (HICs). Aims: An international collaborative initiative aimed at determining whether implementation of a care bundle impro
Introduction: The Hippo signaling pathway is a key regulator of cellular growth and organ size, acting through the transcriptional coactivators YAP and TAZ. These proteins shuttle between the nucleus and cytoplasm in response to Hippo pathway activity, which, when active, leads to cytoplasmic sequestration and degradation of YAP/TAZ, preventing them from initiating gene transcription. Although ini
Objective: Antibiotic prophylaxis reduces infection risk following transrectal prostate biopsy. Studies in countries with high antibiotic resistance show that fosfomycin, given an hour or more before biopsy, has equal or better outcomes than ciprofloxacin. This study aimed to evaluate if fosfomycin, administered immediately before biopsy, is as effective as ciprofloxacin in Sweden, where antibioti
This paper introduces MNE-RT, a Python package designed for real-time neural feature extraction from magne-toencephalography (MEG) and electroencephalography (EEG) signals in Brain-Computer Interface (BCI) systems. The package incorporates efficient algorithms spanning traditional univariate metrics, such as frequency band power and entropy, to advanced bivariate connectivity measures. It is compa
This Registered Report examines urban-rural tensions in Sweden - a historically egalitarian, multi-party welfare state with strong geographical equalization schemes, making it a least-likely case for place-based resentment theories. Using an online survey experiment (n = 2,051), we measured resentment through perceptions of in-group and out-group, and by experimentally varying whether political st
In this article, I identify a key trend for demarcating the “secular” as a Western, Christian achievement. I analyze how the New Testament story often known as “Render unto Caesar” is referenced as a source for the secular West, particularly in writings by European and American conservative thinkers in the 1990s and early 2000s. My argument is that these references to “Render unto Caesar” constitu
Dyslipidemia is increasingly recognized as a potential driver of chronic kidney disease, independent of other components of the metabolic syndrome. This study aimed to investigate the direct impact of isolated dyslipidemia on kidney structure and function in dyslipidemic Psammomys obesus (P. obesus). P. obesus animals were fed either a low-energy diet (LED) or high-energy diet (HED) for 12 weeks.
Ontological insecurity dominates the narratives of fear and anxiety that are perpetuated by populist and authoritarian regimes today. In these discourses and imaginings, specific ideas of ‘security’ are desired as a return to order or an imagined or idealized past. In this chapter, we focus on how those narratives regularly rely on gendered and colonial framings that are associated with weakness a
The introduction presents the 27 chapters of the Handbook on Welfare State Reform by international experts, organized in four parts that provide specific theoretical, methodological, policy-related, as well as reform trend-oriented angles. It begins with contributions providing theoretical lenses and policy paradigms central to the study of welfare state reform. The second part offers an overview
Self-stabilized, heterometallic pair-sites can enable fine-tuning of catalytic functionality while also mitigating dynamic structural changes that degrade catalytic performance. This study demonstrates the development and characterization of trimetallic PtxCrxAg1-2x (x ≤ 0.1) alloys with active Pt–Cr pair-ensembles for non-oxidative ethanol dehydrogenation, leveraging predictions that favorable bo
Adjusting to life at a foreign university can be challenging. For second/foreign language (L2) students, challenges extend beyond adapting to new academic and social contexts. They can involve the need to reappraise individual aspirations and socially grounded expectations relating to language use. In these and other appraisal processes, self-evaluative standards are employed. In L2 learning, self
OVERVIEW: The article explains how Tetra Pak, a global manufacturing company, revamped its product development process (PDP) by transitioning from the traditional Stage-Gate model to a new innovative process that integrates Agile, Lean, Stage-Gate, the Scaled Agile Framework for enterprises (SAFe), and systems engineering methods. The design and implementation of the PDP at Tetra Pak offers insigh
·Public opinion is essential for democratic societies, but social media changes how opinion is formed. ·Affective polarization – the phenomenon that individuals develop strong emotional attachments to their own political group and strong dislike and bias toward political outgroups – is growing in many democratic societies. ·Affective polarization may make individuals more susceptible to belie
In many machine learning tasks, the premise is designed around predetermined targets and clear expectations of model behaviour. In such cases, there is a direct definition of the optimal mappings between inputs and outputs, which can be learned given sufficiently sized datasets and models. However, in many real-world scenarios, tasks are often not as well-posed and instead defined around detecting
Oligometastatic squamous-cell carcinoma of the anus (omSCCA) is a very rare condition. The literature is sparse, and treatment guidelines are lacking. The aim of the present work was to carry out a literature review and to propose an algorithm for intensified treatment of patients with omSCCA. A PubMed search was carried out, which resulted in 15 relevant publications that included any type of def
