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Elevated plasma levels of oxidized low-density lipoprotein (oxLDL) are a risk factor and key component that accelerates and worsens cardiovascular disease fueling inflammation, plaque buildup and vascular damage. OxLDL can elicit its detrimental action via lectin-like oxLDL receptor 1 (LOX-1). In this study, we determined whether oxLDL, via LOX-1, alters aortic vascular reactivity and determined i
Imaging the strain in nanoscale heterostructures is challenging since it requires a combination of high strain sensitivity and spatial resolution. Here, we show that three-dimensional (3D) Bragg coherent diffraction imaging (BCDI) can be used to image the strain in a single InP segment within an axially heterostructured GaInP-InP nanowire. We use a 350 nm-diameter X-ray beam, which is smaller than
This paper discusses a presumed medieval tower in Blekinge. The tower is situated close to a harbour in an inlet of the Baltic just east of modern day Ronnebyhamn. Archaeological investigations in 2021 and 2023 have however firmly dated the tower to the 17th century, making it the first Scandinavian example of a tower-house from the Early Modern era. The tower originally had at least three floor-l
Background: Although glomerular diseases are the third most frequent cause of end-stage kidney disease worldwide, little is known about their long-term outcomes. Methods: In patients with chronic kidney disease (CKD) stage 3–5 enrolled in the Swedish Renal Registry, we compared risks of hospitalization, kidney replacement therapy (KRT), major cardiovascular events (MACE), and death of the four mos
The Baltic Sea has a generally low biodiversity, and several species are declining due to high anthropogenic pressure. One example is the Baltic Sea cod (Gadus morhua, L.), the cod has decreased since the 1980s in both biomass and abundance. One potential solution to increase the cod population is to improve settling ground and provide shelter for juveniles in artificial reefs. The Hanö Cod Reef p
Stimuli-responsive polymers stand out for their ability to respond to small environmental changes. One of the most representative thermo-sensitive materials is poly(N-isopropyl acrylamide) (PNIPAm), which presents reversible phase transitions close to the human body temperature. However, previous studies observed that the copolymerization of NIPAm with small quantities of different monomers like a
The mitochondrial protein NAD(P) + transhydrogenase (NNT) has been implicated in the metabolic derangements observed in obesity. Mice with the C57BL/6J genetic background bear a spontaneous mutation in the Nnt gene and are known to exhibit increased susceptibility to diet-induced metabolic disorders. Most of the studies on NNT in the context of diet-induced obesity have compared C57BL/6J mice with
Hur kan svenska kommuner navigera i en alltmer komplex och osäker framtid? Med intervjuer och dokumentstudier från elva kommuner blottlägger en ny studie de strategiska utmaningarna och belyser vikten av balans mellan kapacitet och öppenhet för nya lösningar. Fyra kommuntyper träder fram.
Aims: Type 2 diabetes (T2D) patients with a clinical phenotype characterized by a high degree of insulin resistance are at increased risk of chronic kidney disease (CKD). We previously demonstrated that the endothelin receptor antagonist (ERA) atrasentan reduced insulin resistance in T2D. In this study, we compared the effect of atrasentan on insulin resistance across different phenotypic clusters
In the work of writing this report, four leading municipal research environments - CERUM, CKS, KEFU, and KFi - with the support of Kommuninvest, have collaborated to explore and understand the complex challenges that Swedish municipalities have had to manage during the transition from relatively favorable economic times to more challenging times, including changed economic conditions and a deterio
Background: The transcription factor Signal Transducer and Activator of Transcription 3 (STAT3) plays a role in carcinogenesis and is involved in processes, such as proliferation, differentiation, drug resistance and immunosuppression. STAT3 can be activated by phosphorylation of tyrosine at position 705 (pSTAT3Tyr705) or serine at 727 (pSTAT3Ser727). High expression levels of pSTAT3 are implicate
The use of extracorporeal life support (ECLS) throughout the perioperative phase of lung transplantation requires nuanced planning and execution by an integrated team of multidisciplinary experts. To date, no multidisciplinary consensus document has examined the perioperative considerations of how to best manage these patients. To address this challenge, this perioperative utilization of ECLS in l
The increase in electric vehicles has led to more vehicles of this kind being involved in accidents. Since there is a risk of a delayed initiation of thermal runaway in these cases, many countries have recommendations for safety distances from crashed vehicles to buildings. This report is a part of the effort to develop similar guidance for Sweden, which was initiated by the Swedish Civil ContingeThe increase in electric vehicles has led to more vehicles of this kind being involved in accidents. Since there is a risk of a delayed initiation of thermal runaway in these cases, many countries have recommendations for safety distances from crashed vehicles to buildings. This report is a part of theeffort to develop similar guidance for Sweden, which was initiated by the Swedish Civil Contingen
BACKGROUND: Physical performance is low and physical activity declines in people with chronic kidney disease (CKD). Both factors are associated with decreased survival. Our hypothesis was that improved physical performance after 12 months of exercise training would result in better survival in patients with CKD stages 3 to 5 not on kidney replacement therapy (KRT). Our aims in this study were to i
Background: Postinfectious autoimmune processes have been proposed as potential causal risk factors for obsessive-compulsive disorder (OCD). In this large population-based study, we aimed to clarify the familial coaggregation pattern between severe infections and OCD across clusters of relatives with varying degrees of relatedness. Methods: We identified 4,916,898 individuals born in Sweden betwee
Time-frequency reassignment, commonly used to analyze time-varying signals, is a post-processing method that sharpens time-frequency representations. However, the reassignment method is sensitive to noise, making it unsuitable for time-frequency analysis when the signal-to-noise ratio is low. To increase the robustness of the reassignment technique, we develop a novel reassigned multitaper spectro
