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Introduction: Having many melanocytic nevi on the skin is a risk factor for melanoma. However, the reproducibility of nevus counts in previous studies is limited due to high inter- and intraobserver variation. Despite the introduction of a protocol for counting and reporting of nevi in 1990 by the International Agency for Research on Cancer (IARC), significant variations in nevus counting methods
This report summarises the results from an interview and literature study carried out to identify key individual qualities for collective problem-solving in a fire and rescue service context. The report contributes to the research project FIRE21 (Fire and Rescue Services in the 21st Century) and is part of a work package looking into such individual qualities through using different methods and ma
The paper details a study that investigated dimensions of mind perception in social agents across various agent types. Factor analysis on 18 mental capacities was conducted across 12 characters, which included 9 social agents - 3 chatbots, 3 voice assistant speakers, and 3 robots. Two factors were identified that roughly aligned with task-oriented and affective-reflective cognitive processes. Base
I denna rapport sammanställer vi resultaten från två workshops som utförts som en del av projektet FIRE21 (Fire and Rescue Services in the 21st Century). I projektet studerar vi (forskare från Sverige, Norge och Danmark) hur räddningstjänster löser problem i så kallade problemlösande nätverk. Vi ser dessa som nödvändiga för att lösa problem i dagens och morgondagens insatser, där vi behöver olika
We study the problem of obtaining lower bounds for polynomial calculus (PC) and polynomial calculus resolution (PCR) on proof degree, and hence by [Impagliazzo et al.'99] also on proof size. [Alekhnovich and Razborov'03] established that if the clause-variable incidence graph of a conjunctive normal form (CNF) formula F is a good enough expander, then proving that F is unsatisfiable requires high
I denna rapport sammanställer vi resultaten från en workshop med Hovedstadens Beredskab i Danmark. Workshopen utfördes som en del av projektet FIRE21 (Fire and Rescue Services in the 21st Century). I projektet studerar vi (forskare från Sverige, Norge och Danmark) hur räddningstjänster löser problem i så kallade problemlösande nätverk. Vi ser dessa som nödvändiga för att lösa problem i dagens och I denna rapport sammanställer vi resultaten från en workshop med Hovedstadens Beredskab i Danmark. Workshopen utfördes som en del av projektet FIRE21 (Fire and Rescue Services in the 21st Century). I projektet studerar vi (forskare från Sverige, Norge och Danmark) hur räddningstjänster löser problem i så kallade problemlösande nätverk. Vi ser dessa som nödvändiga för att lösa problem i dagens och
Chatbots designed to achieve specific goals are increasingly used in service roles. Human-like characteristics in chatbots are seen as beneficial to interaction. Given the purpose-driven nature of goal-oriented chatbots, whether humanlikess of various characteristics of these chatbots has an effect on their perception and use is unclear. This study explores the role of humanlikeness in goal-orient
This report contributes to the research project FIRE21 (Fire and Rescue Services in the 21st Century) and is part of a work package looking into key individual qualities for efficient collective problem-solving in a fire and rescue service (FRS) context.
Semidefinite programs are convex optimization problems involving a linear objective function and a domain of positive-semidefinite matrices. Over the past two decades, they have become an indispensable tool in quantum information science. Many otherwise intractable fundamental and applied problems can be successfully approached by means of relaxation to a semidefinite program. This methodology is
This document summarises key recommendations from project FIRE21. The recommendations are based on results from 1) professionals through the workshop with Räddningstjänsten Syd (Rsyd) and the Norwegian survey and 2) acquired experiences and knowledge from project members.
Rationale: According to the Global Initiative for Obstructive Lung Disease (GOLD), the FEV1/FVC ratio is used to confirm the presence of airflow obstruction in the diagnosis of chronic obstructive pulmonary disease (COPD), whereas FEV1 percent predicted normal value (FEV1%pred) is used for grading its severity. The STaging of Airflow obstruction by the FEV1/FVC Ratio (STAR), and its prediction of
This report summarises a study carried out to identify key individual qualities for collective problem-solving in a fire and rescue service (FRS) context. The report contributes to the research project FIRE21 (Fire and Rescue Services in the 21st Century) and is part of a work package looking into such individual qualities through using different methods and materials.
This article describes the synthesis and characterization of novel cationic five-coordinate Pt(II) complexes containing nitrogen sugar-based ligands. The cytotoxicity of the complexes was evaluated on different cell lines with the expectation that both the coordinative saturation and the sugar moiety cooperate to enhance their biological activity. In fact, the complexes resulted to be more active
Opuntia ficus-indica L. is known for its beneficial effects on human health, but still little is known on cladodes as a potent source of antioxidants. Here, a direct, economic and safe method was set up to obtain water extracts from Opuntia ficus-indica cladodes rich in antioxidant compounds. When human keratinocytes were pre-treated with the extract before being exposed to UVA radiations, a clear
Apolipoprotein E (APOE) is a lipid-transport protein that functions as a key mediator of lipid transport and cholesterol metabolism. Recent studies have shown that peptides derived from human APOE display anti-inflammatory and antimicrobial effects. Here, we applied in vitro assays and fluorescent microscopy to investigate the anti-bacterial effects of full-length APOE. The interaction of APOE wit
The effects of encapsulating the cytotoxic dinuclear trithiolato-bridged arene ruthenium complex [(η6-p-MeC6H4iPr)2Ru2(μ2-S-p-C6H4tBu)3]Cl (DiRu-1) within the apoferritin (AFt) nanocage were investigated. The DiRu-1-AFt nanocarrier was characterized by UV/Vis spectroscopy, ICP-MS, CD and X-ray crystallography. In contrast to previously reported Au- and Pt-based drug-loaded AFt carriers, we found n
Amyloidoses are devastating diseases characterized by accumulation of misfolded proteins which aggregate in fibrils. Specific gene mutations in Apolipoprotein A I (ApoAI) are associated with systemic amyloidoses. Little is known on the effect of mutations on ApoAI structure and amyloid properties. Here we performed a physicochemical characterization of L75P- and L174S-amyloidogenic ApoAI (AApoAI)
New five-coordinate Pt(ii) complexes containing a glycosylated carbene fragment were synthesized. A member of this class shows very high in vitro cytotoxicity and an exceptional selectivity toward malignant cells. The complex lacking the sugary portion fails in the recognition of cancer cells. The results support the use of glycosylation in the design of carbene Pt-based anticancer agents.
The wax apple (Syzygium samarangense) is traditionally employed as an antibacterial and immunostimulant drug in traditional medicine. This plant is rich in different flavonoids and tannins. In this study, we isolated two compounds from S. samarangense leaves: Myricitrin and 3,5-di-O-methyl gossypetin. Then, we investigated the mechanisms of action of the two compounds against oxidative stress (ind
Inorganic trivalent arsenic is a major environmental pollutant and exposure to human results in many pathologies, including keratosis and carcinoma. Here, we analyzed the effects of B. subtilis spores on human normal keratinocytes in the presence of sodium arsenite oxidative stress. Pre-Treatment of cells with spores before inducing oxidative stress was able to keep normal levels of intracellular
