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Cold shock proteins (CSPs) are an ancient and conserved family of proteins. They are renowned for their role in response to low-temperature stress in bacteria and nucleic acid binding activities. In prokaryotes, cold and non-cold inducible CSPs are involved in various cellular and metabolic processes such as growth and development, osmotic oxidation, starvation, stress tolerance, and host cell inv
Governance issues surrounding technologies are profound. This is best illustrated in the context of climate change that does not only exert severe, pervasive and multifaceted impacts on the environment and on the everyday lives of people around the world, but also further aggravates the tension between law, technology and the public in a broader societal context. As a response to feckless global a
In this work, a discontinuous airfoil fin printed circuit heat exchanger (PCHE) was used as a recuperator in a micro gas turbine system. The effects of the airfoil fin geometry parameters (arc height, maximum arc height position, and airfoil thickness) and the airfoil fin arrangements (horizontal and vertical spacings) on the PCHE channel’s thermo-hydraulic performance were extensively examined by
Noninvasive optical imaging through dynamic scattering media has numerous important biomedical applications but still remains a challenging task. While standard diffuse imaging methods measure optical absorption or fluorescent emission, it is also well-established that the temporal correlation of scattered coherent light diffuses through tissue much like optical intensity. Few works to date, howev
Enzalutamide is a second-generation anti-androgen which has shown increased survival in patients with metastatic prostate cancer. However, some patients do not respond to this therapy or will develop resistance to treatment over time. Signal Transducer and Activator of Transcription 3 (STAT3) is known to be involved in castration-resistant prostate cancer and to interact with androgen receptor (AR
Antimicrobial resistance (AMR) is a fast-growing threat to global health. The genes conferring AMR to bacteria are often located on plasmids, circular extrachromosomal DNA molecules that can be transferred between bacterial strains and species. Therefore, effective methods to characterize bacterial plasmids and detect the presence of resistance genes can assist in managing AMR, for example, during
Fast-neutron/gamma-ray pulse-shape discrimination has been performed for the organic liquid scintillators NE 213A and EJ 305 using a time-of-flight based neutron-tagging technique and waveform digitization on an event-by-event basis. Gamma-ray sources and a Geant4-based simulation were used to calibrate the scintillation-light yield. The difference in pulse shape for the neutron and gamma-ray even
Introduction: The sixth Åland Islands Conference on von Willebrand disease (VWD) on the Åland Islands, Finland, was held from 20 to 22 September 2018. Aim: The meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD. Results and discussion: The topics covered both clinical aspects of disease management, and biochemical and labora
Understanding the complete immune cell composition of human neuroblastoma (NB) is crucial for the development of immunotherapeutics. Here, we perform single-cell RNA sequencing (scRNA-seq) on 19 human NB samples coupled with multiplex immunohistochemistry, survival analysis, and comparison with normal fetal adrenal gland data. We provide a comprehensive immune cell landscape and characterize cell-
Coal is used to generate electricity and produce high-value chemicals through coal gasification, liquefaction, and coke. During combustion sulfur is released, which leads to acid rain formation. Mineral matter present in coal is undesirable because it causes technological problems such as corrosion of equipment and reduction of overall rate of combustion of coal. Also, after combustion, the minera
Aim of the studyRates of bystander CPR are increasing, yet mortality after out-of-hospital cardiac arrest (OHCA) remains high. The aim of this survey was to explore public knowledge and attitudes to CPR. Our hypotheses were that recent CPR training (< 5 years) would be associated with a high-quality response in a case vignette of OHCA with agonal breathing, and associated with an interest to becom
AimTo analyze the impact of a time-gain selective, first-responder dispatch system on the presence of a shockable initial rhythm (SIR), return of spontaneous circulation (ROSC) and 30-day survival after out-of-hospital cardiac arrest (OHCA).MethodA retrospective observational study comprising OHCA registry data and dispatch data in the Skåne Region, Sweden (2010–2018). Data were categorized accord
Långt innan poesin blev kärlekens språk var den maktens och hatets tjänare. Än idag är den ett effektivt vapen i kampen om makt och inflytande. I "Poesi som propaganda" berättar propagandaforskaren Jimmy Vulovic om hur och varför dikten så ofta har tvingats tjäna maktens intressen. Med tematiska nedslag i härskarhymner samt krigs-, seger- och gudsdikter tecknas propagandapoesins historia från kils
Ligaments of the knee provide stability and prevent excessive motions of the joint. Rupture of the anterior cruciate ligament (ACL), a common sports injury, results in an altered loading environment for other tissues in the joint, likely leading to their mechanical adaptation. In the collateral ligaments, the patterns and mechanisms of biomechanical adaptation following ACL transection (ACLT) rema
Digital platforms are spreading very fast and new opportunities are emerging in the realm of digital services. But, can any firm easily succeed with a new platform business model? Well, reality seems to be quite complex. Focusing on digital health platforms as examples of new business models in highly regulated sectors, we outline the challenges that platforms should prepare for.
Civil society leadership training programmes are a new phenomenon, and they are often overlooked by civil society scholarship despite being linked to the professionalisation of the sector. In this article, we examine 14 Swedish leadership programmes in order to identify leadership ideals in the sector. Drawing on the notion of ‘symbolic boundaries’, we argue that leadership programmes produce hori
