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INTRODUCTION: The immune microenvironment plays a crucial role in the progression of colorectal cancer (CRC), but its variation across primary tumors and metastatic sites remains incompletely understood. In this study, we compared the composition and prognostic significance of the immune microenvironment in lung metastases, paired primary tumors, and liver metastases from a retrospective cohort of
Climate change is increasingly recognized as a major security concern, with drought–migration–conflict linkages attracting significant attention in both policy and research. While some narratives portray drought as a direct driver of migration and conflict, evidence shows a far more complex relationship: climate stress can lead to more migration in some contexts and less in others, with internal m
Drylands account for a disproportionate share of the world’s armed conflicts, a pattern frequently interpreted through the lens of resource scarcity– where climate change and water stress are seen as primary drivers of violence. While this framing underscores critical environmental pressures, it risks simplifying the complex social, ecological and political realities of these regions. This article
Despite rapid clinical translation, induced pluripotent stem cell (iPSC)-derived therapies face limited global adoption. Harmonized quality control (QC) remains absent, with even fundamental parameters evaluated inconsistently across laboratories. To address this, we conducted two international Quality Assessment Rounds (QARs): QAR 2019 (18 sites, 11 countries) and QAR 2023 (23 sites, 12 countries
When navigating our world, we often feel that we see the whole scene around us. However, large parts of nearby space are often not visible because they are occluded by other objects. Behavioural evidence suggests that such occluded regions can be perceived as empty, which is known as the illusion of absence. Stage magicians use this illusion to make objects appear out of thin air. If an object eme
This thesis is built upon four research projects, in which we investigated different aspects of increasing the diagnostic yield of blood cultures. Blood culture sampling using a single venipuncture (single-sampling strategy, SSS) is non-inferior to sampling from two separate venipunctures when sensitivity is considered. The effect of SSS on blood culture contamination rate is less known. In Study
ObjectivesAthletes competing in blind football have consistently been highlighted as at risk for injuries, and potential concussions. This study described the incidence of injuries sustained by athletes competing in blind football (Football 5-a-side) at the London 2012, Rio 2016 and Tokyo 2020 Paralympic Games. This study described injury proportions and incidences by age, period of competition, o
Book review.
Swedish tragedies from the first half of the eighteenth century often looked at French drama, but there are notable instances where inspiration seems to have come from elsewhere: Erik Wrangel’s Torilla (1738), for example, breaks conventions expected of French theatre by letting princes battle supernatural forces on stage; the story presented in Eric Brander’s Cleopatra (1749) seems familiar from
OBJECTIVE: Tumor deposits (TDs) are a negative prognostic factor in colorectal cancer, independent of lymph node metastasis (LNM). This study aimed to investigate the ability of pre-operative MRI to identify TDs and differentiate them from LNM in rectal cancer.MATERIALS AND METHODS: Patients with histopathological N1-N2 rectal cancer with and without TDs who underwent curative-intent primary surge
Monoclonal gammopathy of undetermined significance (MGUS) is a necessary precursor condition to multiple myeloma (MM). Given the role of autophagy in modulating MM risk, we investigated whether genetic variation in autophagy-related genes influences susceptibility to MGUS. We analyzed the association of 34,042 common autophagy-related single nucleotide polymorphisms (SNPs) with MGUS across six ind
Habitat loss and nutrient enrichment are major drivers of plant species declines. However, local extinction risks vary widely and are shaped by life-history trait syndromes. Genomic life-history traits, which are simple, stable and widely available, offer a promising yet underexplored approach to improving extinction risk assessments and informing conservation efforts. Using a spatial comparison a
Effective and locally supported river restoration requires attention to the social dimensions of rivers. This paper examines local perceptions of hydropower and restoration in the river Rönne å, an early case under Sweden’s National Plan for Modern Environmental Conditions for Hydropower. A mixed-methods approach, including a questionnaire and qualitative interviews, explores how inhabitants relat
The article consists of six core sections. Firstly, it argues for examining the language, origin, use and meaning of key concepts when seeking to understand historical perspectives. Secondly, is a concrete investigation of three concepts related to the French Revolution: ‘historical monument’, ‘vandalism’, and ‘heritage’. Thirdly, it describes how ‘historical monument’ was replaced by ‘heritage’ aThe article consists of six core sections. Firstly, it argues for examining the language, origin, use and meaning of key concepts when seeking to understand historical perspectives. Secondly, is a concrete investigation of three concepts related to the French Revolution: ‘historical monument’, ‘vandalism’, and ‘heritage’. Thirdly, it describes how ‘historical monument’ was replaced by ‘heritage’ a
