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Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. IPF is currently treated with pirfenidone and nintedanib, compounds which slow the rate of disease progression but fail to target underlying pathophysiological mechanisms. The DNA repair protein 8-oxoguanine DNA glyc
Intramolecular hydrogen transfer, a reaction where donor and acceptor sites of a hydrogen atom are part of the same molecule, is a ubiquitous reaction in biochemistry and organic synthesis. In this work, we report hydronium ion (H3O+) production from aminobenzoic acid (ABA) after core-level ionization with soft X-ray synchrotron radiation. The formation of H3O+ during the fragmentation requires th
Purpose: Dichotic speech tests are commonly used in audiological assessments of children with suspected listening difficulties, which may have a range of origins. In Sweden, today, one in four primary schoolchildren has a foreign background, which means that a large proportion of children will be assessed through the medium of a language that they speak at school, but it is not the language they r
The high performance of platinum-Tin catalysts for oxidation reactions has been linked to the formation of tin oxides at the metal surface, but little is known about the structure of these oxides or the chemical behavior that determines their catalytic properties. We show here how surface oxides on Pt3Sn(111) incorporate oxygen at the metal interface, which may be subsequently removed by reaction
I argue that there can be value relations without individual values to support them. The fact that an item is better than another item does not have to be explained by reference to the values of the individual items. Instead, value relations can be grounded directly and exhaustively in descriptive facts about their relata. I show that my suggestion fits well with plausible perspectives on the natu
Dan Egonsson, Björn Petersson, and Toni Rønnow-Rasmussen have been instrumental in shaping the Swedish philosophical community over the last thirty years, particularly in the field of ethics. Through their research, teaching, and guidance of the next generation of philosophers, they have made invaluable contributions to the Department of Philosophy at Lund University. This festschrift, which celeb
This computational study investigates the energy minimum, that is, ground state, of suspensions of monodisperse (single-component) charged linear rods at various densities and screening lengths. We find that closed-packed unidirectional configurations have the lowest energies for all studied cases. We further specify the lattice parameters for these crystalline structures. In addition, we identify
Air pollution research has been conducted in Europe and North America as well as in Asia and South America for decades, but there has, so far, only been a limited amount of studies on air pollution and its health effects conducted in Africa. Until recently, global inventories of pollutants from North America Europe and Asia have been used for air quality and climate change modelling in Africa (Bon
Objective: The association between knee injury and knee osteoarthritis (OA) is understudied relative to its importance, particularly in younger populations. This study was undertaken to examine the association of knee injury with radiographic features of knee OA in military officers, who have a physically demanding profession and high rates of knee injury. Methods: Participants were recruited in 2
Raimo Tuomela’s we-mode groups are partly characterized by norms. Some norms may be characteristic of all we-mode groups, like the norm restricting a member's right to leave the group. Some think that this aspect of Tuomela’s theory has implausible ethical implications concerning the rights and autonomy of members in we-mode groups. That worry vanishes, I argue, on a plausible interpretation of Tu
Vibration reduction index (Kij ) measurements in the field have some challenges compared to laboratory measurements. Firstly, the measurement requires access to a construction site during the short time span when the cross-laminated timber (CLT) elements are apparent. Secondly, building contractors are often on a tight time schedule. Therefore, it is important to find a solution that minimizes the
The study aims to develop an artificial neural networks (ANN) model to estimate the acoustic performance for airborne and impact sound insulation curves of different lightweight wooden floors. The prediction model is developed using 252 standardized laboratory measurement curves in one-third octave bands (50 − 5000 Hz). Each floor structure has been divided into three parts in the database: upper,
Quantifying air-borne and structure-borne sound insulation is an important design consideration for the indoor comfort in a building. Although sound insulation performance is commonly measured experimentally, numerical methods can have time-saving and economic benefits. Further, numerical methods can be incorporated within building simulations to provide an estimate of the acoustic environment. In
In modern industrial settings with small batch sizes it should be easy to set up a robot system for a new task. Strategies exist, e.g. the use of skills, but when it comes to handling forces and torques, these systems often fall short. We introduce an approach that provides a combination of task-level planning with targeted learning of scenario-specific parameters for skill-based systems. We propo
Right before northern hemisphere’s summer shifts to autumn small insect-eatingbirds start lengthy journeys to tropical regions. It is well established that temporarylack food and annual changes in weather are the ultimate reasons for this behavior.On a proximal level however, the process is poorly understood. Yet crosscontinental bird migration is a widespread phenomenon that has evolved severalti
Teacher shortage and turnover is a growing problem in Sweden, yet little is known about the organisational factors associated with these problems. The current study explores teachers’ experiences of organisational processes and aims to identify relevant job demands and resources linked to professional sustainability for teachers. In this study, semi-structured focus group-interviews were conducted
The growing use of mobile technologies is spawning firms’ adoption of mobile relationship-building techniques, including via mobile apps. However, despite the rapid rise of these technologies, little remains known regarding consumers’ mobile app- (vs. desktop browser) related behaviours, and this is therefore investigated in this paper. Specifically, we explore the effect of customer engagement (C
Purpose: This study investigates the mediating role of consumer engagement (CE) in the relationship between perceived behavioral control (PBC) and purchase intent and the moderating role of perceived safety in the relationship between PBC and CE in the self-driving car (SDC) context. Design/methodology/approach: To test the model, a sample of 368 consumers was deployed using partial least-squares
