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Upon activation, vinculin reinforces cytoskeletal anchorage during cell adhesion. Activating ligands classically disrupt intramolecular interactions between the vinculin head and tail domains that bind to actin filaments. Here, we show that Shigella IpaA triggers major allosteric changes in the head domain, leading to vinculin homo-oligomerization. Through the cooperative binding of its three vinc
Space for Peace is a Special Issue that advances the spatial turn in peace and conflict studies. It brings to the fore the purchase of using space as an analytic category by advancing spatial theorization and providing empirical case studies. This introduction draws out the main tenets of spatial approaches and responds to the question: Why space? Moreover, it outlines the chapters in the Special
Den här rapporten handlar om lärande från experiment och vänder sig till dig som arbetar med innovation i svenska regioner och kommuner. I fokus ligger frågor kring organisatoriskt lärande, som här förstås som ett medel för att uppnå strategisk förnyelse av en organisation. Lärande är således nära besläktat med förändring. Vår utgångspunkt är att allt lärande kan förstås som en form av översättnin
Objective: The study objective was to assess the radiological properties of acute type A aortic dissection–related neurological injuries and identify predictors of neurological injury. Methods: Our single-center, retrospective, observational study included all patients who underwent acute type A aortic dissection repair between January 1998 and December 2021. Multivariable analyses and Cox regress
We highlight a new factor behind integration: tolerance in the immigrants’ background culture. We hypothesize that it is easier to partake of economic, civic-political and social life in a new country for a person stemming from a culture that embodies tolerance towards people who are different. We test this by applying the epidemiological method, using a tolerance index based on two indicators fro
Given the outsized impact that digitalization has had on consumption over the last two decades, the lack of academic interest in sustainable consumption is noteworthy. In this book chapter, we set the scene for the fundamentally important discussion about how digitalization affects consumption. We ask whether digitalization is a positive or a negative force for shaping consumption levels and patte
BACKGROUND: Autoantibodies are common in glomerulonephritis, but the clinical benefit of rapid elimination is not determined, even in anti-glomerular basement membrane (GBM) disease. Even less is known about the importance of autoantibody characteristics, including epitope specificity and IgG subclass distribution. By utilizing samples from the GOOD-IDES-01 trial, where imlifidase, cleaving all Ig
Background: Perforator aneurysms of the basilar artery (PABA) are rare causes of subarachnoid haemorrhage (SAH) and challenging to diagnose. We present two cases of SAH caused by PABA diagnosed by cone beam computed tomography angiography (CBCTA) and a novel non-invasive method – 7T magnetic resonance imaging (7T MRI). Methods: Two patients with SAH, diagnosed with PABA, were imaged on day 9 and 1
The dispute over the Diaoyu/Senkaku Islands is generally analysed as a Sino-Japanese competition over material and strategic interests, regional preponderance, and nationalistic symbolism. Yet, such explanations cannot fully explain the endurance of the conflict and overlook its origin in the period leading up to the UN’s derecognition of Taiwan’s sovereignty in 1971. Drawing on the concept of ont
CsPbI3 nanocrystals (CPI NCs) have become a trending research topic due to their impressive potential in functional optoelectronic devices and optical gain applications. Their optical responses are governed by carrier dynamics, which is greatly influenced by temperature and corresponding phase structure due to the effects of inherently electron-phonon coupling. Notably, CPI NCs have been identifie
