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IMPORTANCE COVID-19 can lead to long-term cardiopulmonary symptoms and is associated with coronary microvascular dysfunction (CMD). However, long-term data on CMD after severe COVID-19 are lacking. OBJECTIVE To investigate long-term left ventricular function and the presence of CMD after severe COVID-19. DESIGN, SETTING, AND PARTICIPANTS This case-control study was conducted among patients at a si
Background Although the role of smoking as a risk factor for emphysema in α1-antitrypsin deficiency (AATD) is well known, never-smokers with severe AATD may also develop lung disease, ranging from mild asymptomatic disease to severe emphysema. Methods We performed a cross-sectional and observational study to analyse the characteristics of the population of never-smoker severe AATD (genotype) indiv
Background: Despite recommendations by EU, surveillance of Lyme neuroborreliosis (LNB) is still not fully implemented in all member states, Sweden being one of them. Laboratory-based notifications on positive Borrelia antibody index (AI) in paired cerebrospinal fluid-serum samples alone have been suggested for surveillance of LNB. Objectives: We aim to describe the epidemiology of Lyme borreliosis
This study presents a detailed simulation-based analysis of the detection limits of multi-element monolithic Germanium (Ge) detectors to cadmium traces in environmental soil samples. Using the capabilities of the Geant4 Monte Carlo toolkit in combination with the Solid State Detector Package, we evaluated the detection limit variation with the sample-to-detector distances and photon flux. These si
Objectives: This study aimed to assess the relationship between dietary intake and disease outcomes in patients with radiographic axial spondyloarthritis (r-axSpA), focusing on inflammation and disease activity, while also evaluating other health outcomes, and to compare dietary intake between patients and controls. Method: In a cross-sectional analysis, we studied 295 patients with r-axSpA (modif
Background: Studies in breast cancer patients have consistently shown that physical activity improves survival. We examined if change in physical activity from before to after a breast cancer diagnosis is associated with outpatient specialist care use and hospitalisations in women with type 2 diabetes mellitus (T2DM). Methods: This register-based cohort study included 2145 women with T2DM who self
Background: The recommended treatment for hyposmia (a clinically reduced sense of smell) is olfactory training using odor containers that the patients smell twice a day for several weeks. Adherence to the olfactory training regimen is, however, generally low. We aimed to investigate if a new form of odor delivery, using scented nasal inserts, could enhance adherence to olfactory training by allowi
The chapter examines the flourishing hagiographical production during the Macedonian age, a period marked by intense rewriting of earlier Greek hagiography. This rewriting culminated in the Metaphrastic menologion, compiled by Symeon Metaphrastes in the late tenth century. Following the end of the iconoclastic controversy until Symeon, a clear progression is attested from an initial monastic inter
Proletarization of the countryside featured the birth of modern Sweden. Landless poor, tenants, corvée labourers, indentured servants of the nobility, the freeholders and the industrialists, characterized rural Sweden. This heterogenous group of central Sweden also included a group of Sámi whom, avoiding eviction to the far north, were forced to sign contracts as hunters, butchers, and crafters in
The historical archaeology of early modern churches andchapels in northern Sweden in general and in Norrbotten inparticular is an understudied field of research. The purposeof this paper is to survey the breadth and variation of thechurches and chapels of the Norrbotten region from the latemedieval period to the eighteenth century, with focus on theseventeenth century. In particular the church at
OBJECTIVE: To evaluate short-term outcomes and identify predictors of morbidity and mortality following multivisceral oncologic resections involving the pancreas.SUMMARY BACKGROUND DATA: Multivisceral resections including the pancreas are required for locally advanced abdominal malignancies but are associated with considerable perioperative risk. While smaller series suggest acceptable outcomes in
Smoothing stones from Sami contexts in the 18th and 19th centuries. Smoothing stones of green stone/field stone are sometimes found in both Sámi and non-Sámi contexts from the Iron age and the Medieval period. Usually they are associated with leather or textile production. This paper discusses the findings of natural smoothing stones at three Sámi dwellings in Hälsingland and Gästrikland, central
BACKGROUNDAmyloid beta (Aβ) antibodies are the only therapies to slow cognitive decline in Alzheimer's disease (AD). Yet the sites where antibodies engage Aβ in the brain and mechanisms that lower Aβ are not fully understood. Defining Aβ antibody localizations in the brain is essential to understand how immunotherapy is beneficial for AD.METHODSN-terminal Aβ antibody 6E10 was injected via three di
This thesis aims to strengthen the scientific basis for forensic assessments of single stab injuries to the trunk, which have traditionally been based upon professional experience rather than scientifically evaluated evidence. Using nationwide registries maintained by the Swedish National Board of Forensic Medicine, we conducted five studies including both fatalities and survivors of sharp force t
