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Background: Emerging evidence suggests that anterior cruciate ligament (ACL) ruptures can restore ACL fiber continuity. The relationship between ACL continuity on magnetic resonance imaging (MRI) (sign of ACL healing) and outcomes >5 years after an acute ACL rupture has not been investigated. Purpose: This study aimed to (1) describe clinical outcomes and radiographic osteoarthritis (ROA) at 11 ye

Objectives: The aim was to compare the diagnostic accuracy of magnetic resonance imaging (MRI) at 7 Tesla (T) and 3 T in patients with clinically suspected injury of the triangular fibrocartilage complex (TFCC) or the scapholunate ligament (SLL) using wrist arthroscopy as a reference standard. Methods: Twenty-four patients scheduled for wrist arthroscopy due to suspected TFCC or SLL injury were ex

Lytic polysaccharide monooxygenases (LPMOs) are copper enzymes that boost the degradation of different polysaccharides and play important roles in the sustainable production of biofuels, in human and plant pathogens, and potentially also in plastic degradation. Their activity depends on a co-substrate, where recent results show that hydrogen peroxide is the preferred co-substrate. Under typical ex

Aluminium-based SiC particle-reinforced metal matrix composites are widely used in engineering applications due to their exceptional mechanical properties. However, their machining remains challenging due to the mismatch of material properties between the brittle SiC particles and the ductile aluminium matrix, causing tool wear and surface damage. To mitigate these issues, laser inverse problem sc

After diagnosis of craniopharyngioma, patients frequently develop a rapid weight gain leading to morbid hypothalamic obesity due to disease- and/or treatment-associated hypothalamic lesions. Hypothalamic obesity should be diagnosed and treated in the context of hypothalamic syndrome. Hypothalamic syndrome includes neuroendocrine deficiencies, disruption of circadian rhythm, disturbed hunger-satiet

Sex hormones play an important role in shaping immune responses, which in turn influence reproductive outcomes. The molecular and cellular mechanisms underlying the crosstalk between the immune system, sex hormones, and the reproductive system remain poorly understood. This study addressed this knowledge gap by utilizing single-cell RNA sequencing and proteome analysis to enhance the understanding

The invention relates to High Entropy Alloys for high hardness and high temperature oxidation resistant applications. A new processing method has been developed to prepare the said alloys containing equiatomic ratios of Al, Co, Cr, Fe and Ni to obtain a nanocrystalline phases directly after high energy ball milling. Cr7C3 precipitates having size less than 15 nm are formed through an in-situ react

A new synthetic absorbent, sylopute was applied for the purification of paclitaxel from plant cell cultures and yew tree. There was selective absorption of impurities in the treatment of sylopute. Therefore, higher purity paclitaxel could be obtained simply in the following process with a higher yield than with active clay or activated carbon. The purity of crude paclitaxel after sylopute treatmen

PurposeIn this paper, we discuss common pitfalls in producing review articles for publication in academic journals, offering guidance to minimize rejection rates. We highlight the dual core features of systematicity (i.e. rigor and transparency) and generativity (i.e. advancing knowledge) in review papers. Thereby, we aim to help researchers deal with the abundance of guidelines and create publish

An Escherichia coli expression system was constructed for production of a recombinant antimicrobial peptide buforin derivative named buforin IIb and a large-scale process of cultivation and purification was also developed. Inclusion bodies of fusion proteins containing recombinant buforin IIb were released from high-density-cultured cells by high-pressure homogenization. The inclusion bodies

Paclitaxel was purified from cell cultures of Taxus chinensis by a combination of extraction, low-pressure chromatography, precipitation and HPLC. A crude extract (purity 6.9%) was obtained by methanol extraction of plant cell cultures, followed by liquid–liquid extraction using dichloromethane. The extract was purified to greater than 32% with a 97% step yield by low-pressure chromatography. A

Adsorption isotherms for a packed column consisting of fructose and silica gel in contact with a liquid phase consisting of oleic acid and fructose mono- and di-oleate at 65 °C were determined to assist the column’s utilization in a bioreactor system for the solvent-free lipase-catalyzed synthesis of saccharide ester biosurfactants. The liquid-phase fructose content was very low, ranging from 0.00

Fructose–oleic acid esters, biodegradable, biocompatible and biobased surfactants and value-added products were synthesized under solvent-free conditions at 65 °C in stirred-batch mode and using several different bioreactor systems. For a stirred-tank bioreactor (STBR) using fed-batch fructose addition and 5.0 wt.% immobilized Rhizomucor miehei lipase (Lipozyme® IM, Novozymes, Franklinton, NC), th

The ultrafast energy transfer among the pigments of the B800-850 membrane antenna pigment-protein complex of the photosynthetic purple bacteria Rhodobacter sphaeroides and Rhodopseudomonas palustris LL has been studied with ≈ 100 fs tunable infrared pulses at room temperature and 77 K. It is shown that the B800→B850 transfer time is similar in both species and occurs with a characteristic time con

In this thesis, the inherent oxidation resistance of Al-Co-Cr-Fe-Ni based high entropy alloys have been remarkably enhanced by increasing the grain boundary area and recognizing the influence of the in situ Al2O3 nano-dispersoids. Isothermal continuous oxidation test based on thermogravimetric analysis (TGA) as well as extensive furnace oxidation, were conducted in the elevated temperature range o

Previous work has suggested that the βArg-10 residue forms part of the binding site for the B800 bacteriochlorophyll in the LH2 complex of Rhodobacter sphaeroides [Crielaard, W., Visschers, R. W., Fowler, G. J. S., van Grondelle, R., Hellingwerf, K. J., Hunter, C. N. (1994) Biochim. Biophys. Acta 1183, 473−482], and this is consistent with the X-ray crystallographic data that have been subsequent

Purpose: The purpose is to describe the Malmö Breast Tomosynthesis Screening Project from the beginning to where we are now, and thoughts for the future. Approach: In two acts, we describe the efforts made by our research group to improve breast cancer screening by introducing digital breast tomosynthesis (DBT), all the way from initial studies to a large prospective population-based screening tri

Background: FLASH radiotherapy using megavoltage (MV) photon beams should enable greater therapeutic efficacy, target deep seated tumors, and provide insights into mechanisms within FLASH. Purpose: In this study, we aim to show how to facilitate ultra-high dose rates (FLASH) with MV photons over a field size of 12–15 mm, using a 6 MeV (nominal) preclinical electron linear accelerator (linac). Our

Given the complex nature of agri-food value chains and related sustainability challenges, the question arises who has the agency and responsibility to address these challenges and facilitate systemic change. We address this question through a mixed method approach and examine experiences with agriculture among different actors along the agricultural value chains in Germany. Based on this, we explo

Natural autoantibodies (NAAbs) are immunoglobulins generated in the absence of antigen provocation, with no inherent pathogenic effect, but instead involved in maintaining immune homeostasis. We aimed to evaluate the implication of immunoglobulin G (IgG) antibodies against heat shock protein 90α (HSP90α) in systemic lupus erythematosus (SLE) patients, focusing on how those NAAbs may interfere with