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Purpose Despite increased interest in opioid-free strategies, their clinical uptake remains limited. This study explores Swedish perioperative healthcare professional’s (HCPs) knowledge, attitudes, and practices regarding opioid and nonopioid analgesia across intraoperative and postoperative contexts. Design A national web-based survey was conducted among perioperative HCPs across Sweden between O
Arslan showed that computing all-pairs Hamming distances is easily reducible to arithmetic 0–1 matrix multiplication (IPL 2018). We provide a reverse, linear-time reduction of arithmetic 0–1 matrix multiplication to computing all-pairs distances in a Hamming space. On the other hand, we present a fast randomized algorithm for approximate all-pairs distances in a Hamming space. By combining it with
Purpose – This study examines how representative deliberative processes (RDPs) can operate as systemic policy instruments for addressing complex, place-based societal challenges. By adopting a procedural perspective, the study advances understanding of how deliberation reshapes the internal logic of policymaking, enabling adaptive learning, coordination and institutional transformation. Design/met
Digitalization enables innovative applications in district heating and cooling (DHC), supporting decarbonization and sector integration. These applications rely heavily on data, making the shift toward a data economy a logical next step. A data economy would let stakeholders collect, share, and monetize data, encouraging sustainable innovation. However, limited data availability, interoperability
Introduction: Sepsis, a widespread global ailment, involves an exaggerated immune response, leading to hyperinflammation and immunosuppression. Extracellular histones, released during hyperinflammation as part of the defensive response against pathogens, significantly contribute to sepsis pathogenesis, compromising viability of the host’s endothelial cells and contributing to organ failure. Method
The global rise in youth mental ill-health is exacerbated by a shortage of clinicians trained in evidence-based care, making it difficult to translate research into effective practice – especially for body dysmorphic disorder (BDD), an adolescent-onset condition that often goes undetected and untreated. This study aimed to explore clinicians’ experiences of participation in an online educational p
Aims To explore the prevalence and incidence of paediatric implantable cardioverter-defibrillator (ICD) patients in Sweden and identify risk factors associated with appropriate shocks and adverse events. Methods and results We performed a nationwide, retrospective cohort study of ICD use in paediatric patients (<19 years) between 1995 and 2017; 120 patients underwent ICD implantation at median age
Adaptive life histories emerge through their environmentally dependent effects on fitness. Those effects are consequences of habitat quality and the density-dependent decisions that organisms make on habitat choice. Density dependence for ideal organisms maximizing fitness through habitat selection is uniquely revealed by their habitat isodars, lines in the state space of species’ densities that c
Human appropriation of land reduces the quality and continuity of remaining natural habitat, affecting species fecundity, survival, and movements, which must be accounted for in impact assessments. Effective decision-making for sustainable land-use and resource extraction requires methods that represent the ecological impacts of human activities on surrounding landscapes. We propose a method that
Background/objectives: Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells in response to nutrient ingestion. The aims of this study were: i) to evaluate the cross-sectional associations between plasma GIP change in response to an oral glucose challenge (as a surrogate of GIP secretion) with obesity-related anthropometric measurements, fasting inflammatory bio
We aimed to highlight the roles of the pancreatic enzymes, with special reference to amylase, on glucose homeostasis in healthy pigs and in pigs with exocrine pancreatic insufficiency (EPI). Healthy pigs fed a high-fat diet (HFD) were subjected to mixed meal tolerance tests (MMTTs) and pancreatic enzyme treatments, and then blood glucose and insulin concentrations were determined. Following the de
Butterflies have been systematically monitored in Europe for several decades using standard protocols that are now adopted in over 30 countries. Butterflies are ideal biological indicators: they are well-documented, measurable, sensitive to environmental change, occur in a wide range of habitat types, represent many other insects, and are popular with the public because of their beauty.Records froExecutive Summary Butterflies have been systematically monitored in Europe for several decades using standard protocols that are now adopted in over 30 countries. Butterflies are ideal biological indicators: they are well-documented, measurable, sensitive to environmental change, occur in a wide range of habitat types, represent many other insects, and are popular with the public because of their
Holism is a term charged with multiple meanings. Coined by statesman and botanistJan Smuts in 1926, it was mainly used in academia until its public breakthrougharound 1980. This article examines the interdisciplinary circulation of holism in science during its first sixty years of existence, focusing on ecology, psychology, medicine, social science, pedagogy, and philosophy. While primarily an e
Ongoing global change is leading to the widespread redistribution of species1,2. Assessments of shifts in species geographic ranges, however, remain taxonomically biased and geographically limited2, especially for insects. We conducted a global synthesis on butterfly range shifts using a combination of multi-lingual review in 15 languages and expert assessments, compiling data on range shifts for
