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The transition from batch-wise to integrated continuous manufacturing of biopharmaceuticals has gained significant attention over the past decade. While this concept has been thoroughly studied, there remains significant room for improvement in terms of process automation and real-time monitoring. This study showcases the implementation of an integrated downstream process at a lab scale, operating

Background: Older adults are underrepresented in suicide prevention research, even though suicide rates are higher in this age group (65+) than in any other age group in many countries worldwide. There are few clinical intervention studies that target this age group. A promising preventive intervention is the Attempted Suicide Short Intervention Program (ASSIP). Given differences in suicidal behav

The XAFS-DET work package of the European LEAPS-INNOV project is developing high-purity Germanium detectors for synchrotron applications requiring spectroscopic-grade response. The detectors integrate three key features: (1) newly designed monolithic Germanium sensors optimized to mitigate charge-sharing events, (2) an improved cooling and mechanical design structure supported by thermal simulatio

Background: Actinomycetes of the genus Streptomyces are renowned for their highly developed and diverse specialized metaboliс pathways, and there is an extensive body of data on their specific and pleiotropic levels of regulation. Much less is known about routes leading to essential metabolites in this genus. In this work, we focused on elucidating the function of the highly conserved across Strep

This study examines how two collaborating professions, midwifery and obstetrics, are influenced by women requesting caesarean sections. The empirical material consists of semi-structured interviews with Swedish midwives (n=6) and obstetricians (n=6). Analysed through Tilly’s terms, the categorical pair and triad, midwife and obstetrician function as complementary categories in a triad with the wom

A brain-computer interface (BCI) is a real-time system that converts a user’s brain activity into commands, enabling control over applications such as moving a cursor on the screen. This conversion is made possible by machine learning techniques and other algorithms. Historically, BCI research has focused on the analysis of brain signals offline. However, increasing computational power and algorit

Abstract in French:À travers une approche philologique, cet article tire de l’oubli un duc français qui s’est réfugié en Suède après la Révolution française et qui contribue de manière inattendue et méconnue à l’histoire transnationale entre la France et la Suède. Proche d’Axel de Fersen et introduit dans le cercle amical de la reine Charlotte, le duc de Pienne était en Suède lors du meurtre de FeThrough the use of philology, this article recovers the figure of a French duke who took refuge in Sweden after the French Revolution and who contributes in an unexpected and little-known way to the transnational history between France and Sweden. Close to Axel von Fersen and introduced into Queen Charlotte’s circle of friends, the duc de Pienne was in Sweden at the time of Fersen’s murder, and su

Considering increasing living costs and lagging compensation levels in the welfare system, people on social welfare have difficulties accessing food to the extent needed. This presentation is based on a Swedish study aimed to reveal how migrant welfare recipients act, react, and reason in their management of their own scarce resources and those of others. Striving for ‘dignity’ took a prominent pl

Birds migrate across the globe on their wings, a behavioural adaptation that allows birds to exploit seasonal environments. Their migrations are ultimately influenced by their ability to fly, a costly but high energy-efficient mode of locomotion that enables birds to travel far distances in a short amount of time. This thesis investigates bird migration from a flight energetic perspective, focusin

Classical model reduction techniques project the governing equations onto a linear subspace of the original state space. More recent data-driven techniques use neural networks to enable nonlinear projections. While those often enable stronger compression, they may have redundant parameters and lead to suboptimal latent dimensionality. To overcome these issues, we propose a multistep algorithm that

Vilken ställning hade humaniora i efterkrigstidens Sverige? Vilken plats tog humanister i offentligheten och akademin? Ett samtal med historikerna Anton Jansson och Johan Östling, som tillsammans med Ragni Svensson Stringberg är redaktörer för den nya boken "Humaniora i välfärdssamhället – kunskapshistorier om efterkrigstiden" (Makadam).

The Milky Way provides the most detailed laboratory we have access to for studying the processes of galaxy formation and evolution. Modern large-scale surveys, most notably the Gaia mission, have revolutionised this field by revealing the extent to which the Galaxy is not a steady system, but dynamically active and rich in non-equilibrium features that preserve traces of past interactions. Underst

Many factors influence the language environment in preschool, for example, the language background and competence of the teachers, children's ages, language proficiency levels and language backgrounds, the access to play and learning materials and the composition of preschool groups. There is a lack of knowledge on how various aspects of the interactive language environment in preschool relate to

AIM: To explore nursing students' experiences of what they had learned and gained through participating in simulation-based communication training anchored in person-centred values.BACKGROUND: Person-centredness is a core component of nurses' work and an important part of it is person-centred communication. To promote patients' wellbeing and comfort, nursing students must become prepared during th

The fourth issue of the yearbook History of Intellectual Culture (HIC) features a thematic section on the production of knowledge related to the Holocaust. The contributions focus on the circulation of knowledge via letters and other forms of written communication within and among survivor historical commissions after the Second World War with an emphasis on the interplay of gender and other diffe

Loss and damage in fisheries is acknowledged in climate change policy and science but is both undefined and contested, and there is a lack of empirical exploration of the topic. This paper presents the first in-depth, empirical analysis of how fishers’ situated knowledge of socio-ecological changes can inform our understanding of loss and damage in fisheries. The paper conducts a case study from M

We build on the predictive processing framework to show that intelligent behaviour is adaptive control, driven by accurate prediction and uncertainty reduction in dynamic environments with limited information. We argue that adaptive control arises through a process of re-concretisation, where learned abstractions are grounded in new situations via embodiment. We use this as an explanation of why A

Contractile injection systems (CISs) are phage tail-like nanosyringes that mediate bacterial interactions by puncturing target cell membranes. Within these systems, Photorhabdus Virulence Cassettes (PVCs) can translocate toxins across eukaryotic target cell membranes and have been engineered to deliver diverse protein cargoes into non-natively-targeted organisms. Despite the structural insights in