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Importance Biological staging of Alzheimer disease (AD) can improve diagnostic accuracy and prognostic assessment. However, existing approaches often require invasive procedures and specialized infrastructure, limiting their routine clinical use. Objective To develop and validate a plasma-based biological staging model that closely mirrors an amyloid and tau positron emission tomography (PET)–base
Background: According to the World Health Organization, all healthy pregnant women are recommended to engage in at least 150 min of regular moderate-intensity aerobic activity per week. This level of physical activity is associated with numerous physical and psychological health benefits and helps to reduce the risk of being overweight, gestational diabetes, and preeclampsia. Despite its importanc
Trust is widely recognised as an important determinant of lending relationships, yet existing finance literature typically treats trust as a single construct and rarely examines how different trust dimensions operate across financial contracts with distinct risk structures. Our research addresses this gap by distinguishing between competence-based trust (perceived managerial capability) and value-
Amyloid deposition is a hallmark of numerous age-related diseases, and understanding the chemical mechanisms that govern amyloid formation is crucial for advancing the rational development of protein aggregation inhibitors. With amyloid formation rates varying widely across proteins, here we report the quantitative aggregation mechanism of medin, the most common localized amyloid in humans, and fi
Time-dependent diffusion MRI enables the estimation of water exchange rates in vivo. Most studies attribute these estimates to membrane permeability. However, non-permeative geometric exchange may also contribute. The present study investigates the contribution of geometric exchange between dendritic spines and shafts to diffusion MRI-derived exchange estimates. Monte Carlo simulations were perfor
Inclination-dependent grain boundary (GB) energy and shear-coupled motion are studied for [001] and [111] tilt GBs in face-centered cubic materials using three-dimensional (3D) phase field crystal (PFC) simulations. A large dataset spanning misorientation and inclination space is systematically generated to evaluate trends in GB energy and shear-coupling. GB energy variations broadly follow ideal
Objectives: FLASH radiotherapy is an innovative technique that delivers radiation at ultra-high dose rates (UHDR), offering tumor control comparable to conventional (CONV) radiotherapy while significantly reducing normal tissue toxicity. Here we aim to determine the effects of FLASH compared to CONV radiotherapy in muscle-invasive bladder cancer (MIBC) models. Methods: Using an in-house 6 MeV line
Aims: To describe healthcare professionals’ interactions with pediatric patients at an adult ICU. Methods: This non-participant naturalistic observational study was conducted at two adult ICUs in Sweden. Inclusion criteria were children aged 0–15 years, where both the child and the parent could speak and understand Swedish or English. Children undergoing palliative care were excluded. The observat
This study presents a multidisciplinary analysis of 119 osseous and ivory fragments from the necropolis of La Beleña (Córdoba, Spain) dating between the second half of the 4th and the beginnings of the 3rd Millennium BC, aiming to assess the effectiveness and limitations of current methods used for identifying ivory provenance in prehistoric contexts. Traditional macroscopic and microscopic techni
BACKGROUND: Obesity is a major risk factor for heart failure (HF). However, individuals with similar body mass index (BMI), the main diagnostic measure of obesity, exhibit considerable heterogeneity in developing HF.OBJECTIVES: This study aimed to investigate the association between metabolically discordant subgroups characterized by cardiometabolic biomarkers deviated from those predicted by BMI
BACKGROUND: The EAT-Lancet Commission introduced the planetary health diet to promote human health while reducing environmental impact. However, no study has yet examined how adherence to this diet is associated with risk of irritable bowel syndrome (IBS).OBJECTIVE: This study aimed to investigate the association between the planetary health diet index (PHDI) and the risk of developing IBS.METHODS
Seasonality can drive the evolution of reproductive plasticity in insects. An extreme form is reproductive diapause, where individuals halt reproduction during unfavourable seasons. How diapause evolves from milder forms of plasticity (e.g., through changes in cue perception and responses) is poorly understood. In the tropics, seasonality is common, but it is unclear how widespread reproductive pl
Bimanual motor performance declines with age and is accompanied by cortical thinning and alterations in white matter microstructure within motor control networks. Aging is also associated with increased interindividual variability in behavioral and structural markers, and some studies report stronger brain-behavior associations in older compared with younger adults. We tested whether bimanual perf
The systematic placement of the enigmatic South African moth Apoprogones hesperistis Hampson, which superficially resembles hesperiid skippers and sematurid moths, has long been controversial. Its rarity has hindered detailed morphological study, and the absence of fresh material has precluded molecular analyses. We investigated its phylogenetic position using non-destructive DNA extraction from t
Rationale & Objective: Sedentarism and low health-related quality of life (HRQoL) are common in people receiving hemodialysis, and innovative approaches are needed to improve HRQoL. Aims: We investigated the feasibility and safety of an intradialytic exercise intervention using the GoodRENal virtual reality platform in people receiving hemodialysis and tested the impact on physical function an
Copper, the most efficient catalyst for multicarbon (C2+) product generation in electrochemical CO2 reduction (CO2R), is highly susceptible to restructuring in the presence of halides. Chloride ions enhance the performance of Cu catalysts, although a detailed understanding of the morphological and chemical evolution induced by chloride remains lacking. In this work, in situ scanning transmission s
Background: We investigated whether individuals who likely developed type 2 diabetes (T2D) through predominantly genetic, adverse intrauterine, or lifestyle aetiologies have different clinical presentations and complications. Methods: In this Danish nationwide combined cross-sectional and registry-based follow-up study, we included 7867 individuals with newly diagnosed T2D from the DD2 cohort, enr
Large-scale stratiform clouds are widespread and dominate the Earth's radiation budget. Their radiative and microphysical properties are inseparable, depending on ambient aerosol conditions and on properties of any convective outflow. In the Community Atmospheric Model, version 6 (CAM6), large-scale clouds were originally treated two decades ago with a two-moment bulk microphysics approach. Since
Background: As a surrogate for eosinophilic activation, eosinophil-derived neurotoxin (EDN) is a potential clinical biomarker. However, EDN levels and discriminatory ability in different asthma phenotypes are unknown. We quantified serum and nasal lavage fluid (NLF) EDN levels and assessed the potential to differentiate clinically defined asthma phenotypes in an adult-representative sample. Method
