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The chaperone protein DNAJB6b exhibits intrinsic activity in inhibiting amyloid fibril formation, although the underlying mechanism remains unclear. A key region, comprising residues 132-183 and rich in serine and threonine residues, commonly referred to as the “S/T region”, has been shown to play a critical role in this function. While deletion of the S/T region does not disrupt the folding of DN
