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Protein–protein interactions are fundamental to biological functions as well as the design of new functional food products and biomedicines. However, they can be challenging to computationally quantify due to strong forces and sensitivity to pronounced solution conditions. This thesis combines computational methods with Monte Carlo simulations to investigate strong protein interactions in diverse
Optical sensor technologies are central to the advancement of Internet of Things (IoT) ecosystems and smart systems. Among these, photodetectors—a key subset of optical sensors—find extensive applications in areas such as smart sensing, home automation, autonomous vehicles, wearable electronics, and AI-driven platforms. The demand for highly sensitive, cost-effective, flexible, and lightweight pho
The androgen receptor (AR) is a critical driver of prostate cancer (PCa). Here, to study regulators of AR protein levels and oncogenic activity, we developed a live-cell quantitative endogenous AR fluorescent reporter. Leveraging this AR reporter, we performed genome-scale CRISPRi flow cytometry sorting screens to systematically identify genes that modulate AR protein levels. We identified and val
The ability to control the morphology of organic semiconductor nanoparticles is of paramount importance for applications in organic photovoltaics, photocatalysis, and photo-triggered biological applications. In this paper, we demonstrate that nanoprecipitation is a powerful technique to provide a variety of morphologies in binary blends of organic semiconductors. By investigating seven different d
Horizontal drift of the beam on the MAX IV soft x-ray beamlines was observed with a 1-2 hour settling time and strong dependence on the undulator power setting. A water cooled, suspended electrode was designed and is shown to reduce the horizontal beam drift on three MAX IV soft x-ray beamlines to acceptable operational levels.
BACKGROUND AND OBJECTIVES: Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by 3 core symptom complexes: parkinsonism, cerebellar syndrome, and dysautonomia. Recent Movement Disorder Society (MDS) criteria allow for the clinical diagnosis of MSA based solely on motor symptoms, without requiring dysautonomia. This study aimed to evaluate the frequency and disease trajecto
Endovascular therapy (EVT) has proven benefit for patients with anterior circulation large vessel occlusion (LVO) strokes with moderate-to-severe deficits, but its value in patients presenting 6-24 hours after onset with mild symptoms (NIH Stroke Scale score ≤5) remains unclear. This journal club article examines a retrospective analysis of CLEAR registry data comparing EVT with medical management
The Dupljaja loess-palaeosol sequence in the southeasternmost sector of the Banat Loess Plateau, Serbia, is of significant palaeoenvironmental importance. Situated within the southeastern Carpathian (Middle Danube) Basin, it provides valuable insights into the climatic evolution during the last glacial period and role of the southeastern Carpathians as a potential migration corridor for early huma
In this chapter, the salutogenic framework is applied as a theoretical foundation for health promotion. Health promotion and salutogenesis are intertwined. In this chapter, they are therefore compared using their respective value sets in the search for coherent interpretations. Some core concepts of salutogenesis and health promotion, such as health, wellbeing, quality of life and human rights are
Background The prognostic value of fractional flow reserve (FFR) in assessing coronary stenosis before transcatheter aortic valve replacement (TAVR) is unclear. Objectives The aim of this study was to evaluate cardiovascular risks associated with significant and nonsignificant FFR values of coronary stenosis prior to TAVR. Methods Patients were enrolled from the NOTION-3 (Nordic Aortic Valve Inter
Interference between scattering channels is observed in resonant inelastic x-ray scattering (RIXS) at the Ne K threshold. Final states with |2p-1np⟩ as the main configuration are populated via |1s-1n′p⟩ resonances, where large-amplitude one-electron (n′=n) channels interfere with small-amplitude two-electron (n′≠n) channels. The interference is manifested in an asymmetric line profile where the tw
Background: Hearing loss is estimated to affect more than 20% of the global population. Hearing aid fitting is a common intervention in audiological rehabilitation; however, there are still those who struggle with remaining communication difficulties that require additional intervention. The group rehabilitation program Active Communication Education (ACE) has been shown to be an effective alterna
Bakgrund: Cancer ökar globalt och trots att fler överlever så lever fortfarande många med kvarstående symtom som påverkar vardagen. Aktivitet och delaktighets positiva inverkan på människans välbefinnande är välbeforskat. Däremot finns det lite forskning kring hur cancer påverkar människans aktivitet och delaktighet. Syfte: Syftet är att sammanställa hur tidigare forskning beskriver hur cancer ochBackground: Cancer is increasing globally and although more people are surviving, many still live with residual symptoms that affect everyday life. Activity and particapations impact on peoples well-being are well studied. However there is little research on how cancer affects activity and participation. Purpose: The aim of this study was to describe how cancer and its consequences affect activi
Bakgrund: Folkhögskolan är ett unikt nordiskt fenomen med stor möjlighet till anpassning av studierna. Studier i sig påverkar aktivitetsbalansen, vilken är upplevelsen av balans mellan måsten och meningsfulla aktiviteter. Folkhögskolestuderande är en underbeforskad grupp framförallt inom arbetsterapi. För att beskriva komplexiteten i aktivitetsbalans används aktivitetsvetenskapliga modeller. SyfteBackground: Folk high schools are a uniquely Nordic phenomenon with individualized pedagogy. Studying affects occupational balance, which is the experience of balance between tasks and meaningful activities. Folk high school students as a group are not widely researched, particularly in combination with occupational therapy. To describe the complexity of occupational balance, models linked to occu
With the adoption of the New Pact on Migration and Asylum, the European Union (EU) and its Member States are encouraged to cooperate with third States through informal agreements, notably in the form of Memoranda of Understanding (MoUs). These arrangements form a central component of the EU’s externalisation strategy, shifting its borders outwards and thereby limiting the circumstances under which
This thesis examines the extent to which the French and Swiss models of corporate criminal liability may inform the development of proposals to extend the jurisdiction of the International Criminal Court (ICC) to encompass legal persons. The study employs a combination of doctrinal and comparative legal methodology, with particular emphasis on the legal models through which criminal liability may
Uttalanden från Lagrådet har gett skäl att begrunda huruvida den överlåtna normgivningskompetensen till Europeiska unionen är så omfattande och betydelsefull att riksdagens ställning urholkas i väsentlig grad. Mot den bakgrunden är syftet med denna undersökning att utreda hur EU-medlemskapet påverkar riksdagens lagstiftningsmakt. För att uppfylla syftet används en metod som kan liknas vid en jämfStatements by the Council on Legislation have given cause to consider whether the regulatory powers transferred to the European Union are so extensive and significant that they substantially undermine the position of the Riksdag. Against this background, the purpose of this thesis is to examine how EU membership affects the legislative power of the Riksdag. To achieve this purpose, a method is us
I uppsatsen undersöks flyktingdefinitionen i ljuset av intersektionalitet som teoretiskt ramverk utifrån 4 kap. 1 § utlänningslagen och mot bakgrund av artikel 1A(2) i flyktingkonventionen. Analysen omfattar flyktingdefinitionen i gällande rätt och dess tillämpning i svenska migrationsdomstolar. Fokus är på de två elementen förföljelsegrunderna och förföljelse på kumulativa grunder i definitionen.In this thesis, the refugee definition is examined in the light of intersectionality as a theoretical framework based on Chapter 4, Section 1 of the Swedish Aliens Act and against the background of Article 1A(2) of the Refugee Convention. The thesis analyses the refugee definition in current law, as well as its application in Swedish migration courts, focusing on the grounds of persecution and per
Bakgrund: Förlossningsrädsla är vanligt förekommande bland gravida kvinnor och definieras som en intensiv rädsla eller oro inför förlossning. Förlossningsrädslan påverkar deras upplevelse av graviditet och förlossning negativt och barnmorskan har en stor roll i att stötta kvinnor med förlossningsrädsla. Syfte: Syftet var att beskriva barnmorskors upplevelser av att stötta gravida kvinnor med förlo
