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Background: The development of axonal pathology is a key characteristic of many neurodegenerative disease such as Parkinson's disease and Alzheimer's disease. With advanced disease progression, affected axons do display several signs of pathology such as swelling and fragmentation. In the AAV vector-mediated alpha-synuclein overexpression model of Parkinson's disease, large (> 20 µm2) pathological

BACKGROUND: Neuropsychiatric (NP) involvement and fatigue are major problems in systemic lupus erythematosus (SLE). S100A8/A9 is a marker of inflammation and responds to therapy in SLE patients. S100A8/A9 has an immunopathogenic role in various neurological diseases. We investigated S100A8/A9 in relation to NP-involvement and fatigue in SLE.METHODS: 72 consecutive SLE outpatients at a tertiary cen

Background and objectivesDarkness is a significant barrier to children’s independent mobility (Shaw et al., 2015) affecting the perception and use of outdoor environments, making them less attractive, and increasing social fears (Cele, 2019). This literature review addresses the question of how artificial outdoor lighting may serve to provide children independent mobility after dark.Process and meBackground and objectivesDarkness is a significant barrier to children’s independent mobility (Shaw et al., 2015) affecting the perception and use of outdoor environments, making them less attractive, and increasing social fears (Cele, 2019). This literature review addresses the question of how artificial outdoor lighting may serve to provide children independent mobilityafter dark.Process and met

The formation of sustainable entrepreneurial ecosystems to foster sustainable entrepreneurship in regional and national levels has become an increasing phenomenon. Therefore, the research stream of sustainable entrepreneurial ecosystems is gaining relevance in the sustainable entrepreneurship literature. What has been missing, however, is an empirical analysis of stakeholder collaborations in sust

This important Research Handbook explores the nexus between human rights, poverty and inequality as a critical lens for understanding and addressing key challenges of the coming decades, including the objectives set out in the Sustainable Development Goals. The Research Handbook starts from the premise that poverty is not solely an issue of minimum income and explores the profound ways that depriv

In this study, a new method was developed to successfully design sustainable microfibers from wheat gluten proteins using a nonreducing solvent and electrospinning. We explored the morphology by X-ray tomography, scanning electron microscopy (SEM), and confocal laser scanning microscopy (CLSM), protein chemistry and cross-linking by size exclusion-high-performance liquid chromatography (SE-HPLC),

Background: The Catquest-9SF questionnaire is a patient reported outcome measure that quantifies the visual benefits from cataract surgery. The purpose of this study was to translate and adapt the Catquest-9SF questionnaire for France, to assess its psychometric properties via Rasch analysis, and to assess its validity when completed using an electronic notepad. Methods: The Catquest-9SF questionn

Data from the Swedish Renal Registry (SRR) show that during the period March 16, 2020 to March 15, 2021 0.4% of all renal transplant recipients and 3% of all dialysis patients died due to COVID-19 in Sweden. Of all registered deaths, 20% were attributed to COVID-19.  In the age group 50-59 years the risk ratio for COVID-19 related mortality was 16 (95% CI 6.5-38) among transplant recipients and 22

We demonstrate a compact, bulk multi-pass cell with high-transmission, for compressing the output of a 30W, 250fs Ytterbium source to 31fs with a resulting peak power of 2.5GW.

We present high-power Yb:YAG lasers combined with nonlinear pulse compression in multi-pass cells. We show that these are suitable for integration in FEL facilities in terms of pulse stability, jitter, temporal contrast and intra-burst behaviour.

Background: Few studies have focused on the prevalence of abdominal obesity in Chinese middle-aged and older adults with a normal body mass index (BMI). Furthermore, it is still unclear whether abdominal obesity is an independent risk factor for type 2 diabetes mellitus (T2DM). Participants with a normal BMI are usually neglected during assessments of abdominal obesity-associated T2DM risk since t

Traumatic knee injury is common in physical activity that includes jumping and cutting movements, and most commonly include anterior cruciate ligament (ACL) or meniscus injuries. Surgical or non-surgical intervention strategies may be chosen, but treatment will include a physical-therapist led physical training program. The aim of this training is to strengthen and stabilize the knee. Despite rece

This study appraised and compared the performance of process-based hydrological SWAT (soil and water assessment tool) with a machine learning-based multi-layer perceptron (MLP) models for simulating streamflow in the Upper Indus Basin. The study period ranges from 1998 to 2013, where SWAT and MLP models were calibrated/trained and validated/tested for multiple sites during 1998–2005 and 2006–2013,

Drawing on selected discourses of non-essentialist ecofeminism, this article proposes and substantiates an ecofeminist position. This distinct position is shown to bring with it a capacity to challenge widely uncontested, corporate-produced truths regarding the benefits and the legitimacy of certain commercial activities. Three historical cases inform the discussion: the fights led by Rachel Carso