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We analyzed a comprehensive set of single-nucleotide polymorphisms (SNPs) and length polymorphisms in the interferon regulatory factor 5 (IRF5) gene for their association with the autoimmune disease systemic lupus erythematosus (SLE) in 485 Swedish patients and 563 controls. We found 16 SNPs and two length polymorphisms that display association with SLE (P < 0.0005, OR > 1.4). Using a Bayesian mod
If $S$ is a hyponormal operator, then Putnam's inequality gives an estimate on the norm of the self-commutator $[S^*,S]$, while the Berger-Shaw theorem gives (under appropriate cyclicity hypotheses) a corresponding estimate on the trace of $[S^*,S]$. Of course these results hold when $S$ is subnormal. In the subnormal setting, the author obtains useful estimates on the norm and essential norm of
Several studies have demonstrated the hybrid origin of Squalius alburnoides, a complex of diploid, triploid and tetraploid fish, with Squalius pyrenaicus as the maternal ancestor and an Anaecypris hispanica-like species as the paternal ancestor. The aim of this study was to assess patterns of genetic diversity and similarity between sympatric forms of the different ploidy levels of S. alburnoides
Two ADP receptors have been identified on human platelets: P2Y(1) and P2Y(12). The P2Y(12) receptor blocker clopidogrel is widely used to reduce the risks in acute coronary syndromes, but, currently, there is no P2Y(1) blocker in clinical use. Evidence for variable responses to clopidogrel has been described in several reports. The mechanistic explanation for this phenomenon is not fully understoo
Existing literature is overwhelmingly sceptical about the capacity of the Council Presidency to shape the EU agenda. The Presidency's ability to promote private concerns is considered highly limited and, typically, the Presidency is depicted as a "responsabilité sans pouvior'. This article challenges the conventional wisdom on theoretical and empirical grounds. Theoretically, it develops a concept
Altered immunological functions and changes in the monoaminergic neurotransmitter systems are two important observations made previously in the study of possible etiological and pathophysiological factors for psychiatric disorders. In search of tentative autoimmune mechanisms involved in these disorders we studied the presence of immunoglobulin G (DA-IgG) with affinity for the monoamine dopamine (
For the design of a new separation process based on unfolding and refolding of protein, the partitioning behaviour of proteins was studied in thermoseparating polymer two-phase systems with varying pH and temperature. Chymotrypsin inhibitor 2 (CI2), which unfolds reversibly in a simple two-state manner, was partitioned in an aqueous two-phase system (ATPS) composed of a random copolymer of ethylen
PURPOSE: The aim of this study was to investigate the influence of a computer-based decision support system (DSS) on performance and inter-observer variability of interpretations regarding ischaemia and infarction in myocardial perfusion scintigraphy (MPS). METHODS: Seven physicians independently interpreted 97 MPS studies, first without and then with the advice of a DSS. Four physicians had long
The study, comprising 125 sick-listed women aged 25-64 (m = 46.9 years) with widespread chronic pain, aimed at evaluating biopsychosocial problems as perceived by these women, studying such problems within a contextual framework, relating the findings to sociodemographic and medical data. Musculoskeletal complaints, fatigue, inability to work, sleep disturbances and uncertainty about the future we
Immotile-cilia syndrome is characterized by severe respiratory distress from early infancy, and also often by situs inversus. The first description of the disease was based on just four persons, but reasons were given to suggest that the disorder may not be exceedingly rare. The purpose of the present study was to estimate just how rare or how common it is and to evaluate its association with situ
Juvenile bird migrants are generally believed to use a clock-and-compass migratory orientation strategy. According to such a strategy migrants accomplish their migration by flying a number of successive flight steps with direction and number of steps controlled by an endogenous programme. One powerful way of testing this is by comparing predictions from a model of such a strategy with observed pat
Artikeln analyserar ur ett historiskt perspektiv två förbundssammanslagningar som under 2000-talet berört TCOs och SACOs största förbund inom privat sektor: bildandet av Unionen 1/1 2008 resp. Sveriges Ingenjörer 1/1 2007. Tidigare - mestadels aldrig fullföljda - sammanslagningsförsök som involverat Sif, HTF, Handels, Transport, SKTF, ST m fl fackförbund behandlas också, liksom den fram till HTFs
It is unclear whether thromboprophylaxis produces a consistent risk reduction in different subgroups of medical patients at risk from venous thromboembolism. We performed a retrospective, post hoc analysis of 3706 patients enrolled in the PREVENT study. Patients were at least 40 years old with an acute medical condition requiring hospitalization for at least 4 days and had no more than 3 days of i
Stable isotopes of nitrogen (delta(15) N) and carbon (delta C-13) were measured for Atlantic salmon Salmo salar and their intestinal cestode, Eubothrium crassum, sharing the same diet. Atlantic salmon muscle tissues were enriched in N-15 and depleted in C-13 compared to their prey (sprat Sprattles sprattus sprattus) and their intestinal cestode. There was no significant difference in delta N-15 or
Structural manifestations of Alzheimer's disease (AD) including neuronal loss were investigated in 12 cases of AD and in 10 healthy age-matched controls, with focus on the cerebellum. Linear Purkinje cell (PC) density was measured in the vermis and cerebellar hemispheres. Neurons were also counted in the inferior olivary nucleus. In vermis of the AD cases, the mean PC number was significantly lowe
The preoperative fine-needle aspiration cytology (FNAC) diagnoses in 116 surgically excised neurilemomas were reviewed and compared with the corresponding histopathologic diagnoses made on surgical specimens and with clinical data. In addition, the utility of adjunctive techniques was analyzed and other spindle-cell lesions in the differential diagnoses were discussed. An unequivocal, benign diagn
Aims/hypothesis Children with high-risk type 1 diabetes HLA genotype have increased risk of high relative birthweight (HrBW), while cord blood islet autoantibodies decrease the risk. As gestational infections may affect offspring type 1 diabetes risk, the aims were to test whether: (1) children of mothers reporting gestational infections have increased HrBW; (2) gestational infections explain isle
The withdrawal reflex system of higher vertebrates has been extensively used as a model for spinal sensorimotor integration, nociceptive processing and plasticity. In the rat, the nociceptive withdrawal reflex system appears to have a modular organization. Each reflex module controls a single muscle or a few synergistic muscles, and its cutaneous receptive field corresponds to the skin area withdr
